Magnetic resonance imaging, cognition, and sex differences in Parkinson’s disease with REM sleep behavior disorder

[eng] INTRODUCTION: This doctoral thesis is centered on Parkinson’s disease (PD) with rapid eye movement sleep behavior disorder (RBD) as a clinical subtype. Characterizing subtypes is one of the main ongoing objectives of translational research on neurodegenerative diseases. Therefore, subtyping is...

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Autor: Oltra González, Javier
Tipo de recurso: tesis doctoral
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/206860
Acceso en línea:https://hdl.handle.net/2445/206860
http://hdl.handle.net/10803/689943
Access Level:acceso abierto
Palabra clave:Malaltia de Parkinson
Trastorns del son
Ressonància magnètica
Parkinson's disease
Sleep disorders
Magnetic resonance
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oai_identifier_str oai:diposit.ub.edu:2445/206860
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Magnetic resonance imaging, cognition, and sex differences in Parkinson’s disease with REM sleep behavior disorder
title Magnetic resonance imaging, cognition, and sex differences in Parkinson’s disease with REM sleep behavior disorder
spellingShingle Magnetic resonance imaging, cognition, and sex differences in Parkinson’s disease with REM sleep behavior disorder
Oltra González, Javier
Malaltia de Parkinson
Trastorns del son
Ressonància magnètica
Parkinson's disease
Sleep disorders
Magnetic resonance
title_short Magnetic resonance imaging, cognition, and sex differences in Parkinson’s disease with REM sleep behavior disorder
title_full Magnetic resonance imaging, cognition, and sex differences in Parkinson’s disease with REM sleep behavior disorder
title_fullStr Magnetic resonance imaging, cognition, and sex differences in Parkinson’s disease with REM sleep behavior disorder
title_full_unstemmed Magnetic resonance imaging, cognition, and sex differences in Parkinson’s disease with REM sleep behavior disorder
title_sort Magnetic resonance imaging, cognition, and sex differences in Parkinson’s disease with REM sleep behavior disorder
dc.creator.none.fl_str_mv Oltra González, Javier
author Oltra González, Javier
author_facet Oltra González, Javier
author_role author
dc.contributor.none.fl_str_mv Junqué i Plaja, Carme, 1955-
Segura i Fàbregas, Bàrbara
Universitat de Barcelona. Facultat de Medicina i Ciències de la Salut
dc.subject.none.fl_str_mv Malaltia de Parkinson
Trastorns del son
Ressonància magnètica
Parkinson's disease
Sleep disorders
Magnetic resonance
topic Malaltia de Parkinson
Trastorns del son
Ressonància magnètica
Parkinson's disease
Sleep disorders
Magnetic resonance
description [eng] INTRODUCTION: This doctoral thesis is centered on Parkinson’s disease (PD) with rapid eye movement sleep behavior disorder (RBD) as a clinical subtype. Characterizing subtypes is one of the main ongoing objectives of translational research on neurodegenerative diseases. Therefore, subtyping is expected to play a relevant role in future precision medicine prevention, diagnosis, and treatment approaches. In this context, PD with RBD appears as a severe clinical subtype previously associated with worse clinical, cognitive, and neurodegenerative outcomes. However, the whole-brain functional connectivity of this clinical subtype has never been explored, and evidence about the brain correlates of its cognitive impairment is still scarce. The influence of sex in neurodegenerative diseases has been overlooked by previous research. Prior findings point to severe cognitive impairment and neurodegenerative profile in male PD patients. Besides, the study of the effect of sex at different stages of the disease, particularly in an early phase and on the eventual severe clinical subtypes, such as PD with RBD, could enhance the current understanding of the impact of this variable in PD. This knowledge might lead to more appropriate diagnostic strategies and specific therapeutic options in the future. HYPOTHESES: The main hypotheses of this thesis are: 1. PD-pRBD will be characterized by specific structural and functional MRI brain features associated with cognitive impairment. 2. There will be identified sex differences in cognition and structural MRI brain features in de novo PD, with worse cognitive profile and pattern of neurodegeneration in males than females. The sex differences among de novo PD patients will be more extended in the PD-pRBD group compared with the PD without probable RBD (PD- non pRBD) group. OBJECTIVES: The main objectives of this thesis are: 1. To characterize structural and functional magnetic resonance imaging (MRI) brain substrates in PD with probable RBD (PD-pRBD) and their correlates with cognitive impairment. 2. To explore sex differences in cognition and structural MRI brain features in de novo PD and de novo PD-pRBD.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
info:eu-repo/semantics/publishedVersion
format doctoralThesis
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/206860
http://hdl.handle.net/10803/689943
url https://hdl.handle.net/2445/206860
http://hdl.handle.net/10803/689943
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv cc by-nc-nd (c) Oltra González, Javier, 2024
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Oltra González, Javier, 2024
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universitat de Barcelona
publisher.none.fl_str_mv Universitat de Barcelona
dc.source.none.fl_str_mv Tesis Doctorals - Facultat - Medicina i Ciències de la Salut
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Magnetic resonance imaging, cognition, and sex differences in Parkinson’s disease with REM sleep behavior disorderOltra González, JavierMalaltia de ParkinsonTrastorns del sonRessonància magnèticaParkinson's diseaseSleep disordersMagnetic resonance[eng] INTRODUCTION: This doctoral thesis is centered on Parkinson’s disease (PD) with rapid eye movement sleep behavior disorder (RBD) as a clinical subtype. Characterizing subtypes is one of the main ongoing objectives of translational research on neurodegenerative diseases. Therefore, subtyping is expected to play a relevant role in future precision medicine prevention, diagnosis, and treatment approaches. In this context, PD with RBD appears as a severe clinical subtype previously associated with worse clinical, cognitive, and neurodegenerative outcomes. However, the whole-brain functional connectivity of this clinical subtype has never been explored, and evidence about the brain correlates of its cognitive impairment is still scarce. The influence of sex in neurodegenerative diseases has been overlooked by previous research. Prior findings point to severe cognitive impairment and neurodegenerative profile in male PD patients. Besides, the study of the effect of sex at different stages of the disease, particularly in an early phase and on the eventual severe clinical subtypes, such as PD with RBD, could enhance the current understanding of the impact of this variable in PD. This knowledge might lead to more appropriate diagnostic strategies and specific therapeutic options in the future. HYPOTHESES: The main hypotheses of this thesis are: 1. PD-pRBD will be characterized by specific structural and functional MRI brain features associated with cognitive impairment. 2. There will be identified sex differences in cognition and structural MRI brain features in de novo PD, with worse cognitive profile and pattern of neurodegeneration in males than females. The sex differences among de novo PD patients will be more extended in the PD-pRBD group compared with the PD without probable RBD (PD- non pRBD) group. OBJECTIVES: The main objectives of this thesis are: 1. To characterize structural and functional magnetic resonance imaging (MRI) brain substrates in PD with probable RBD (PD-pRBD) and their correlates with cognitive impairment. 2. To explore sex differences in cognition and structural MRI brain features in de novo PD and de novo PD-pRBD.[cat] INTRODUCCIÓ: La tesi doctoral se centra en l'estudi de la malaltia de Parkinson (MP) amb trastorn de conducta del son REM (TCR) com a subtipus clínic de la MP. En recerca translacional, la caracterització de subtipus és un dels principals objectius en l’estudi de les malalties neurodegeneratives. Així mateix, s'espera en el futur que la identificació de subtipus tingui un paper important en les estratègies de prevenció, diagnòstic i tractament en l’àmbit de la medicina de precisió. En aquest context, la MP amb TCR apareix com a un subtipus clínic greu que prèviament s’ha associat amb pitjors característiques clíniques, cognitives, d’atròfia cerebral i pronòstic més desfavorable. Malgrat els estudis previs de ressonància magnètica (RM), la connectivitat funcional del cervell mai ha estat explorada en aquest subtipus clínic i l’evidència pel que fa als correlats cerebrals del seu deteriorament cognitiu és encara molt escassa. D’altra banda, la influència del sexe en les malalties neurodegeneratives és un aspecte rellevant que no ha estat degudament atès fins fa poc. Les principals troballes prèvies mostren un perfil de deteriorament cognitiu i de neurodegeneració més greu en pacients homes amb MP. L’estudi de l’efecte del sexe en diferents estadis de la malaltia, particularment en etapes inicials, i més en concret en aquells subtipus més greus, com ara la MP amb TCR, podria suposar un avanç en el coneixement de l’impacte d’aquesta variable. En un futur, aquest tipus de troballes podrien afavorir la implementació d’estratègies més acurades de diagnòstic i tractament individualitzat. HIPÒTESIS: Les principals hipòtesis d’aquesta tesi són : 1. Els pacients amb MP amb probable TCR presentaran característiques diferencials en mesures de RM estructural i funcional respecte als pacients sense TCR. El major deteriorament cognitiu estarà associat a les alteracions cerebrals regionals més marcades en la MP amb probable TCR. 2. S’identificaran diferències entre sexes en cognició i atrofia regional en pacients amb MP de novo. S’espera trobar major afectació en homes. Les diferències entre sexes en MP de novo seran més extenses en el grup de MP amb probable TCR en comparació amb el grup sense TCR. OBJECTIUS: Els principals objectius d'aquesta tesi són: 1. Caracteritzar estructuralment i funcionalment mitjançant anàlisis d’imatges de RM la MP amb probable TCR i correlacionar les seves característiques amb el deteriorament cognitiu. 2. Explorar les diferències entre sexes en cognició i mesures de RM estructural en MP de novo i en MP de novo amb probable TCR.Universitat de BarcelonaJunqué i Plaja, Carme, 1955-Segura i Fàbregas, BàrbaraUniversitat de Barcelona. Facultat de Medicina i Ciències de la Salut2022info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/206860http://hdl.handle.net/10803/689943Tesis Doctorals - Facultat - Medicina i Ciències de la Salutreponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaIngléscc by-nc-nd (c) Oltra González, Javier, 2024http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2068602026-05-27T06:46:51Z
score 15.300724

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