Organocatalytic N-formylation of amines by CO2 in batch and continuous flow
A continuous flow organocatalytic synthesis of formamides has been developed using amines and CO2 reaction partners in the presence of a silane reductant. The process is conducted under comparatively mild reaction conditions and allows the preparation of a broad family of N-substituted formamides in...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2072/532765 |
| Acceso en línea: | http://hdl.handle.net/2072/532765 https://doi.org/10.1039/d2qo01711c |
| Access Level: | acceso abierto |
| Palabra clave: | Química 09 |
| Sumario: | A continuous flow organocatalytic synthesis of formamides has been developed using amines and CO2 reaction partners in the presence of a silane reductant. The process is conducted under comparatively mild reaction conditions and allows the preparation of a broad family of N-substituted formamides in good yield. The heterogenized catalyst is a PS-supported superbase (DBU), while (MeO)3SiH proved to be the most efficient reductant. The reaction was first optimized in batch mode, giving access to fifteen different N-substituted formamide products. The optimized conditions were then used as input to develop a proof-of-concept continuous flow process based on the model substrate N-phenyl aniline thereby providing N methyl-N-phenyl formamide as target with good productivity. |
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