Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence

Inflammatory processes described in Parkinson’s disease (PD) and its animal models appear to be important in the progression of the pathogenesis, or even a triggering factor. Here we review that peripheral inflammation enhances the degeneration of the nigrostriatal dopaminergic system induced by dif...

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Autores: Machado Quintana, Alberto, Herrera Carmona, Antonio José, Venero Recio, José Luis, Santiago Pavón, Martiniano, Martínez de Pablos, Rocío, Villarán, Ruth, Espinosa Oliva, Ana María, Argüelles Castilla, Sandro, Sarmiento Soto, Manuel, Delgado Cortés, M.J., Mauricio, R., Cano, Josefina
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2011
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/41595
Acceso en línea:http://hdl.handle.net/11441/41595
https://doi.org/10.4061/2011/393769
Access Level:acceso abierto
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spelling Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidenceMachado Quintana, AlbertoHerrera Carmona, Antonio JoséVenero Recio, José LuisSantiago Pavón, MartinianoMartínez de Pablos, RocíoVillarán, RuthEspinosa Oliva, Ana MaríaArgüelles Castilla, SandroSarmiento Soto, ManuelDelgado Cortés, M.J.Mauricio, R.Cano, JosefinaInflammatory processes described in Parkinson’s disease (PD) and its animal models appear to be important in the progression of the pathogenesis, or even a triggering factor. Here we review that peripheral inflammation enhances the degeneration of the nigrostriatal dopaminergic system induced by different insults; different peripheral inflammations have been used, such as IL-1β and the ulcerative colitis model, as well as insults to the dopaminergic system such as 6-hydroxydopamine or lipopolysaccharide. In all cases, an increased loss of dopaminergic neurons was described; inflammation in the substantia nigra increased, displaying a great activation of microglia along with an increase in the production of cytokines such as IL-1βand TNF-α. Increased permeability or disruption of the BBB, with overexpression of the ICAM-1 adhesion molecule and infiltration of circulating monocytes into the substantia nigra, is also involved, since the depletion of circulating monocytes prevents the effects of peripheral inflammation. Data are reviewed in relation to epidemiological studies of PDHindawi Publishing CorporationBioquímica y Biología Molecular2011info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/11441/41595https://doi.org/10.4061/2011/393769reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésParkinson's Disease, 1-11.10.4061/2011/393769info:eu-repo/semantics/openAccessoai:idus.us.es:11441/415952026-06-17T12:51:07Z
dc.title.none.fl_str_mv Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence
title Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence
spellingShingle Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence
Machado Quintana, Alberto
title_short Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence
title_full Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence
title_fullStr Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence
title_full_unstemmed Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence
title_sort Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence
dc.creator.none.fl_str_mv Machado Quintana, Alberto
Herrera Carmona, Antonio José
Venero Recio, José Luis
Santiago Pavón, Martiniano
Martínez de Pablos, Rocío
Villarán, Ruth
Espinosa Oliva, Ana María
Argüelles Castilla, Sandro
Sarmiento Soto, Manuel
Delgado Cortés, M.J.
Mauricio, R.
Cano, Josefina
author Machado Quintana, Alberto
author_facet Machado Quintana, Alberto
Herrera Carmona, Antonio José
Venero Recio, José Luis
Santiago Pavón, Martiniano
Martínez de Pablos, Rocío
Villarán, Ruth
Espinosa Oliva, Ana María
Argüelles Castilla, Sandro
Sarmiento Soto, Manuel
Delgado Cortés, M.J.
Mauricio, R.
Cano, Josefina
author_role author
author2 Herrera Carmona, Antonio José
Venero Recio, José Luis
Santiago Pavón, Martiniano
Martínez de Pablos, Rocío
Villarán, Ruth
Espinosa Oliva, Ana María
Argüelles Castilla, Sandro
Sarmiento Soto, Manuel
Delgado Cortés, M.J.
Mauricio, R.
Cano, Josefina
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Bioquímica y Biología Molecular
description Inflammatory processes described in Parkinson’s disease (PD) and its animal models appear to be important in the progression of the pathogenesis, or even a triggering factor. Here we review that peripheral inflammation enhances the degeneration of the nigrostriatal dopaminergic system induced by different insults; different peripheral inflammations have been used, such as IL-1β and the ulcerative colitis model, as well as insults to the dopaminergic system such as 6-hydroxydopamine or lipopolysaccharide. In all cases, an increased loss of dopaminergic neurons was described; inflammation in the substantia nigra increased, displaying a great activation of microglia along with an increase in the production of cytokines such as IL-1βand TNF-α. Increased permeability or disruption of the BBB, with overexpression of the ICAM-1 adhesion molecule and infiltration of circulating monocytes into the substantia nigra, is also involved, since the depletion of circulating monocytes prevents the effects of peripheral inflammation. Data are reviewed in relation to epidemiological studies of PD
publishDate 2011
dc.date.none.fl_str_mv 2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11441/41595
https://doi.org/10.4061/2011/393769
url http://hdl.handle.net/11441/41595
https://doi.org/10.4061/2011/393769
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Parkinson's Disease, 1-11.
10.4061/2011/393769
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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