Prevalence of chronic rhinosinusitis without/with nasal polyps according to severity in Spain

This manuscript contains online supplementary material

Detalles Bibliográficos
Autores: Mullol, Joaquim, Sastre Domínguez, Joaquín, Domínguez Ortega, Javier, Blanco Aparicio, Marina, Castillo Vizuete, José Antonio, Alobid, Isam, García-Vitoria, Montse, Palomo-Jiménez, Paloma I.
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:dnet:biblosearchi::a6b7654904ddceb2529e05949b6eebc7
Acceso en línea:https://hdl.handle.net/10486/762580
https://dx.doi.org/10.4193/Rhin23.341
Access Level:acceso abierto
Palabra clave:chronic rhinosinusitis
nasal polyps
comorbidity
prevalence
type-2 inflammation
Medicina
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spelling Prevalence of chronic rhinosinusitis without/with nasal polyps according to severity in SpainPrevalence of chronic rhinosinusitis in SpainMullol, JoaquimSastre Domínguez, JoaquínDomínguez Ortega, JavierBlanco Aparicio, MarinaCastillo Vizuete, José AntonioAlobid, IsamGarcía-Vitoria, MontsePalomo-Jiménez, Paloma I.chronic rhinosinusitisnasal polypscomorbidityprevalencetype-2 inflammationMedicinaThis manuscript contains online supplementary materialBackground: The worldwide prevalence range of chronic rhinosinusitis (CRS) is 5-12%; from this, 20 % have nasal polyps. Due to the little epidemiological data about CRS in the Spanish population, this study analyses the prevalence and severity of CRS with (CRSwNP) or without (CRSsNP) nasal polyps, and their connection with other coexisting type 2 inflammatory diseases in Spain. Methodology: This is a retrospective, large-scale, nationwide, epidemiological study based on the electronic medical records from the BIG-PAC® database. Patients diagnosed of CRSsNP and CRSwNP were identified using specific disease codes. The severe form of the disease was defined as patients who received at least a long course of antibiotics in CRSsNP or ≥2 short courses of systemic corticosteroids in CRSwNP in ≤12 months during the last 2 years, and/or had previous sinus surgery. Physician-diagnosed prevalence, sociodemographic and clinical characteristics, and disease severity were assessed. Results: Out of a cohort of 1,012,257 patients (≥18 years old), 42,863 and 7,550 patients with diagnosed CRSsNP and CRSwNP, respectively, were analysed. The overall prevalence of diagnosed CRS was 5.1%, being 4.3% and 0.8% for CRSsNP and CRSwNP, respectively. Patients with CRSwNP and severe forms of the disease were older and had higher levels of type 2 inflammatory biomarkers than CRSsNP patients and non-severe disease. Conclusions: Although CRSsNP was more prevalent than CRSwNP, the severe forms of CRS were more frequent in patients with CRSwNP. In addition, CRSwNP patients had a higher incidence of coexisting type 2 inflammatory diseasesThis study was funded by SanofiJournal of the International Rhinologic SocietyFacultad de MedicinaDepartamento de Medicina20242024-08-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1EVoRhttp://purl.org/coar/version/c_dc82b40f9837b551info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10486/762580https://dx.doi.org/10.4193/Rhin23.34138830185reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dnet:biblosearchi::a6b7654904ddceb2529e05949b6eebc72026-06-23T12:46:27Z
dc.title.none.fl_str_mv Prevalence of chronic rhinosinusitis without/with nasal polyps according to severity in Spain
Prevalence of chronic rhinosinusitis in Spain
title Prevalence of chronic rhinosinusitis without/with nasal polyps according to severity in Spain
spellingShingle Prevalence of chronic rhinosinusitis without/with nasal polyps according to severity in Spain
Mullol, Joaquim
chronic rhinosinusitis
nasal polyps
comorbidity
prevalence
type-2 inflammation
Medicina
title_short Prevalence of chronic rhinosinusitis without/with nasal polyps according to severity in Spain
title_full Prevalence of chronic rhinosinusitis without/with nasal polyps according to severity in Spain
title_fullStr Prevalence of chronic rhinosinusitis without/with nasal polyps according to severity in Spain
title_full_unstemmed Prevalence of chronic rhinosinusitis without/with nasal polyps according to severity in Spain
title_sort Prevalence of chronic rhinosinusitis without/with nasal polyps according to severity in Spain
dc.creator.none.fl_str_mv Mullol, Joaquim
Sastre Domínguez, Joaquín
Domínguez Ortega, Javier
Blanco Aparicio, Marina
Castillo Vizuete, José Antonio
Alobid, Isam
García-Vitoria, Montse
Palomo-Jiménez, Paloma I.
author Mullol, Joaquim
author_facet Mullol, Joaquim
Sastre Domínguez, Joaquín
Domínguez Ortega, Javier
Blanco Aparicio, Marina
Castillo Vizuete, José Antonio
Alobid, Isam
García-Vitoria, Montse
Palomo-Jiménez, Paloma I.
author_role author
author2 Sastre Domínguez, Joaquín
Domínguez Ortega, Javier
Blanco Aparicio, Marina
Castillo Vizuete, José Antonio
Alobid, Isam
García-Vitoria, Montse
Palomo-Jiménez, Paloma I.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Facultad de Medicina
Departamento de Medicina
dc.subject.none.fl_str_mv chronic rhinosinusitis
nasal polyps
comorbidity
prevalence
type-2 inflammation
Medicina
topic chronic rhinosinusitis
nasal polyps
comorbidity
prevalence
type-2 inflammation
Medicina
description This manuscript contains online supplementary material
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-08-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
EVoR
http://purl.org/coar/version/c_dc82b40f9837b551
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10486/762580
https://dx.doi.org/10.4193/Rhin23.341
38830185
url https://hdl.handle.net/10486/762580
https://dx.doi.org/10.4193/Rhin23.341
identifier_str_mv 38830185
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Journal of the International Rhinologic Society
publisher.none.fl_str_mv Journal of the International Rhinologic Society
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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