Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence

BACKGROUND: Sensitization in early childhood may precede respiratory allergy in adolescence. METHODS: IgE reactivity against 132 allergen molecules was evaluated using the MeDALL microarray in sera obtained from a random sample of 786 children at the age of 4, 8 and 16years in a population based bir...

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Autores: Wickman, Magnus, Lupinek, Christian, Andersson, Niklas, Belgrave, Danielle, Asarnoj, Anna, Benet, Marta, Pinart Gilberga, Mariona, Wieser, Sandra, García Aymerich, Judith, Baar, Alexandra, Pershagen, Göran, Simpson, Angela, Kull, Inger, Bergstrom, Anna, Melén, Erik, Hamsten, Carl, Antó i Boqué, Josep Maria, Bousquet, Jean, Custovic, Adnan, Valenta, Rudolf, Hage, Marianne van
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/119080
Acceso en línea:https://hdl.handle.net/2445/119080
Access Level:acceso abierto
Palabra clave:Asma infantil
Malalties de l'aparell respiratori en els infants
Asthma in children
Respiratory diseases in children
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spelling Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in AdolescenceWickman, MagnusLupinek, ChristianAndersson, NiklasBelgrave, DanielleAsarnoj, AnnaBenet, MartaPinart Gilberga, MarionaWieser, SandraGarcía Aymerich, JudithBaar, AlexandraPershagen, GöranSimpson, AngelaKull, IngerBergstrom, AnnaMelén, ErikHamsten, CarlAntó i Boqué, Josep MariaBousquet, JeanCustovic, AdnanValenta, RudolfHage, Marianne vanAsma infantilMalalties de l'aparell respiratori en els infantsAsthma in childrenRespiratory diseases in childrenBACKGROUND: Sensitization in early childhood may precede respiratory allergy in adolescence. METHODS: IgE reactivity against 132 allergen molecules was evaluated using the MeDALL microarray in sera obtained from a random sample of 786 children at the age of 4, 8 and 16years in a population based birth cohort (BAMSE). Symptoms were analyzed by questionnaire at ages 4, 8 and 16years. Clinically and independent relevant allergen molecules accounting for >/=90% of IgE reactivities in sensitized individuals and at all time-points were identified as risk molecules and used to predict respiratory allergy. The data was replicated in the Manchester Asthma and Allergy Study (MAAS) birth cohort by studying IgE reactivity with the use of a commercial IgE microarray. Sera were obtained from children at the ages of 3, 5, 8 and 11years (N=248) and the outcome was studied at 11years. FINDINGS: In the BAMSE cohort 4 risk molecules could be identified, i.e.: Ara h 1 (peanut), Bet v 1 (birch), Fel d 1 (cat), Phl p 1 (grass). For MAAS the corresponding number of molecules was 5: Der p 1 (dust mite), Der f 2 (dust mite), Phl p 1 (grass), Phl p 5 (grass), Fel d 1 (cat). In BAMSE, early IgE reactivity to >/=3 of 4 allergen molecules at four years predicted incident and persistent asthma and/or rhinitis at 16years (87% and 95%, respectively). The corresponding proportions in the MAAS cohort at 16years were 100% and 100%, respectively, for IgE reactivity to >/=3 of 5 risk molecules. INTERPRETATIONS: IgE reactivity to a few allergen molecules early in life identifies children with a high risk of asthma and/or rhinitis at 16years. These findings will be of importance for developing preventive strategies for asthma and rhinitis in children.Elsevier2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/119080Articles publicats en revistes (ISGlobal)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1016/j.ebiom.2017.11.009EBioMedicine, 2017, vol. 26, p. 91-99http://dx.doi.org/10.1016/j.ebiom.2017.11.009info:eu-repo/grantAgreement/EC/FP7/261357cc by-nc-nd (c) Elsevier, 2017http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1190802026-05-27T06:46:51Z
dc.title.none.fl_str_mv Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence
title Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence
spellingShingle Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence
Wickman, Magnus
Asma infantil
Malalties de l'aparell respiratori en els infants
Asthma in children
Respiratory diseases in children
title_short Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence
title_full Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence
title_fullStr Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence
title_full_unstemmed Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence
title_sort Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence
dc.creator.none.fl_str_mv Wickman, Magnus
Lupinek, Christian
Andersson, Niklas
Belgrave, Danielle
Asarnoj, Anna
Benet, Marta
Pinart Gilberga, Mariona
Wieser, Sandra
García Aymerich, Judith
Baar, Alexandra
Pershagen, Göran
Simpson, Angela
Kull, Inger
Bergstrom, Anna
Melén, Erik
Hamsten, Carl
Antó i Boqué, Josep Maria
Bousquet, Jean
Custovic, Adnan
Valenta, Rudolf
Hage, Marianne van
author Wickman, Magnus
author_facet Wickman, Magnus
Lupinek, Christian
Andersson, Niklas
Belgrave, Danielle
Asarnoj, Anna
Benet, Marta
Pinart Gilberga, Mariona
Wieser, Sandra
García Aymerich, Judith
Baar, Alexandra
Pershagen, Göran
Simpson, Angela
Kull, Inger
Bergstrom, Anna
Melén, Erik
Hamsten, Carl
Antó i Boqué, Josep Maria
Bousquet, Jean
Custovic, Adnan
Valenta, Rudolf
Hage, Marianne van
author_role author
author2 Lupinek, Christian
Andersson, Niklas
Belgrave, Danielle
Asarnoj, Anna
Benet, Marta
Pinart Gilberga, Mariona
Wieser, Sandra
García Aymerich, Judith
Baar, Alexandra
Pershagen, Göran
Simpson, Angela
Kull, Inger
Bergstrom, Anna
Melén, Erik
Hamsten, Carl
Antó i Boqué, Josep Maria
Bousquet, Jean
Custovic, Adnan
Valenta, Rudolf
Hage, Marianne van
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Asma infantil
Malalties de l'aparell respiratori en els infants
Asthma in children
Respiratory diseases in children
topic Asma infantil
Malalties de l'aparell respiratori en els infants
Asthma in children
Respiratory diseases in children
description BACKGROUND: Sensitization in early childhood may precede respiratory allergy in adolescence. METHODS: IgE reactivity against 132 allergen molecules was evaluated using the MeDALL microarray in sera obtained from a random sample of 786 children at the age of 4, 8 and 16years in a population based birth cohort (BAMSE). Symptoms were analyzed by questionnaire at ages 4, 8 and 16years. Clinically and independent relevant allergen molecules accounting for >/=90% of IgE reactivities in sensitized individuals and at all time-points were identified as risk molecules and used to predict respiratory allergy. The data was replicated in the Manchester Asthma and Allergy Study (MAAS) birth cohort by studying IgE reactivity with the use of a commercial IgE microarray. Sera were obtained from children at the ages of 3, 5, 8 and 11years (N=248) and the outcome was studied at 11years. FINDINGS: In the BAMSE cohort 4 risk molecules could be identified, i.e.: Ara h 1 (peanut), Bet v 1 (birch), Fel d 1 (cat), Phl p 1 (grass). For MAAS the corresponding number of molecules was 5: Der p 1 (dust mite), Der f 2 (dust mite), Phl p 1 (grass), Phl p 5 (grass), Fel d 1 (cat). In BAMSE, early IgE reactivity to >/=3 of 4 allergen molecules at four years predicted incident and persistent asthma and/or rhinitis at 16years (87% and 95%, respectively). The corresponding proportions in the MAAS cohort at 16years were 100% and 100%, respectively, for IgE reactivity to >/=3 of 5 risk molecules. INTERPRETATIONS: IgE reactivity to a few allergen molecules early in life identifies children with a high risk of asthma and/or rhinitis at 16years. These findings will be of importance for developing preventive strategies for asthma and rhinitis in children.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/119080
url https://hdl.handle.net/2445/119080
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1016/j.ebiom.2017.11.009
EBioMedicine, 2017, vol. 26, p. 91-99
http://dx.doi.org/10.1016/j.ebiom.2017.11.009
info:eu-repo/grantAgreement/EC/FP7/261357
dc.rights.none.fl_str_mv cc by-nc-nd (c) Elsevier, 2017
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Elsevier, 2017
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (ISGlobal)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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