Decreased Doublecortin (DCX) immunoreactivity in hippocampus after profound sensorineural hearing loss and vestibular dysfunction in adult mice

Objective: sensorineural hearing loss (SNHL) and bilateral vestibulopathy (BV) have been associated with cognitive decline and incident dementia. Our aim was to investigate the combined effect of profound SNHL and BV on spatial cognition and hippocampal neurogenesis in adult mice. Methods: Single or...

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Autores: Rompaey, Vincent Van, Liesenborghs, Alex, Goyvaerts, Karel, Herd, Daan De, Verdoodt, Dorien, Lammers, Marc, Heyning, Paul Van De, Vanderveken, Olivier, Szewczyk, Krystyna, Thys, Sofie, Pintelon, Isabel, Timmermans, Jean Pierre, Llorens i Baucells, Jordi, Deyn, Peter De, Dam, Debby Van
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/182348
Acceso en línea:https://hdl.handle.net/2445/182348
Access Level:acceso abierto
Palabra clave:Sordesa
Demència
Deafness
Dementia
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spelling Decreased Doublecortin (DCX) immunoreactivity in hippocampus after profound sensorineural hearing loss and vestibular dysfunction in adult miceRompaey, Vincent VanLiesenborghs, AlexGoyvaerts, KarelHerd, Daan DeVerdoodt, DorienLammers, MarcHeyning, Paul Van DeVanderveken, OlivierSzewczyk, KrystynaThys, SofiePintelon, IsabelTimmermans, Jean PierreLlorens i Baucells, JordiDeyn, Peter DeDam, Debby VanSordesaDemènciaDeafnessDementiaObjective: sensorineural hearing loss (SNHL) and bilateral vestibulopathy (BV) have been associated with cognitive decline and incident dementia. Our aim was to investigate the combined effect of profound SNHL and BV on spatial cognition and hippocampal neurogenesis in adult mice. Methods: Single oral intake of allylnitrile produces otovestibular failure in less than a week. Behavioral assessment included recording of spontaneous activity, motor activity, spatial cognition, etc. Evaluation of hippocampal neurogenesis was performed 8 weeks after treatment by quantification of neural precursor cells and proliferating cells in the dentate gyrus by staining with doublecortin (Dcx) and Ki67, respectively. Results: Profound SNHL and BV were confirmed in the allylnitrile-treated mice respectively by means of auditory brainstem response (ABR) and acoustic startle response, and several vestibular tests. Spatial cognitive deficits, i.e. higher latency to target, were observed with the Barnes maze. In the right hemisphere, no statistically significant difference was observed between groups. In the left hemisphere, the difference in mean cell densities of Dcx positive cells was statistically significant when compared to the control group, whereas the difference in mean cell density of Ki67 positive cells did not differ significantly. Conclusion: Spatial cognitive deficits and decreased immunoreactivity to DCX in the left hippocampus were observed 8 weeks after adult mice acquired profound SNHL and BV.AVES Publishing Co.2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/182348Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.5152/B-ENT.2021.21452B-ENT, 2021, vol. 17, num. 4, p. 223-223https://doi.org/10.5152/B-ENT.2021.21452cc by (c) Rompaey, Vincent Van et al, 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1823482026-05-27T06:46:51Z
dc.title.none.fl_str_mv Decreased Doublecortin (DCX) immunoreactivity in hippocampus after profound sensorineural hearing loss and vestibular dysfunction in adult mice
title Decreased Doublecortin (DCX) immunoreactivity in hippocampus after profound sensorineural hearing loss and vestibular dysfunction in adult mice
spellingShingle Decreased Doublecortin (DCX) immunoreactivity in hippocampus after profound sensorineural hearing loss and vestibular dysfunction in adult mice
Rompaey, Vincent Van
Sordesa
Demència
Deafness
Dementia
title_short Decreased Doublecortin (DCX) immunoreactivity in hippocampus after profound sensorineural hearing loss and vestibular dysfunction in adult mice
title_full Decreased Doublecortin (DCX) immunoreactivity in hippocampus after profound sensorineural hearing loss and vestibular dysfunction in adult mice
title_fullStr Decreased Doublecortin (DCX) immunoreactivity in hippocampus after profound sensorineural hearing loss and vestibular dysfunction in adult mice
title_full_unstemmed Decreased Doublecortin (DCX) immunoreactivity in hippocampus after profound sensorineural hearing loss and vestibular dysfunction in adult mice
title_sort Decreased Doublecortin (DCX) immunoreactivity in hippocampus after profound sensorineural hearing loss and vestibular dysfunction in adult mice
dc.creator.none.fl_str_mv Rompaey, Vincent Van
Liesenborghs, Alex
Goyvaerts, Karel
Herd, Daan De
Verdoodt, Dorien
Lammers, Marc
Heyning, Paul Van De
Vanderveken, Olivier
Szewczyk, Krystyna
Thys, Sofie
Pintelon, Isabel
Timmermans, Jean Pierre
Llorens i Baucells, Jordi
Deyn, Peter De
Dam, Debby Van
author Rompaey, Vincent Van
author_facet Rompaey, Vincent Van
Liesenborghs, Alex
Goyvaerts, Karel
Herd, Daan De
Verdoodt, Dorien
Lammers, Marc
Heyning, Paul Van De
Vanderveken, Olivier
Szewczyk, Krystyna
Thys, Sofie
Pintelon, Isabel
Timmermans, Jean Pierre
Llorens i Baucells, Jordi
Deyn, Peter De
Dam, Debby Van
author_role author
author2 Liesenborghs, Alex
Goyvaerts, Karel
Herd, Daan De
Verdoodt, Dorien
Lammers, Marc
Heyning, Paul Van De
Vanderveken, Olivier
Szewczyk, Krystyna
Thys, Sofie
Pintelon, Isabel
Timmermans, Jean Pierre
Llorens i Baucells, Jordi
Deyn, Peter De
Dam, Debby Van
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Sordesa
Demència
Deafness
Dementia
topic Sordesa
Demència
Deafness
Dementia
description Objective: sensorineural hearing loss (SNHL) and bilateral vestibulopathy (BV) have been associated with cognitive decline and incident dementia. Our aim was to investigate the combined effect of profound SNHL and BV on spatial cognition and hippocampal neurogenesis in adult mice. Methods: Single oral intake of allylnitrile produces otovestibular failure in less than a week. Behavioral assessment included recording of spontaneous activity, motor activity, spatial cognition, etc. Evaluation of hippocampal neurogenesis was performed 8 weeks after treatment by quantification of neural precursor cells and proliferating cells in the dentate gyrus by staining with doublecortin (Dcx) and Ki67, respectively. Results: Profound SNHL and BV were confirmed in the allylnitrile-treated mice respectively by means of auditory brainstem response (ABR) and acoustic startle response, and several vestibular tests. Spatial cognitive deficits, i.e. higher latency to target, were observed with the Barnes maze. In the right hemisphere, no statistically significant difference was observed between groups. In the left hemisphere, the difference in mean cell densities of Dcx positive cells was statistically significant when compared to the control group, whereas the difference in mean cell density of Ki67 positive cells did not differ significantly. Conclusion: Spatial cognitive deficits and decreased immunoreactivity to DCX in the left hippocampus were observed 8 weeks after adult mice acquired profound SNHL and BV.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/182348
url https://hdl.handle.net/2445/182348
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.5152/B-ENT.2021.21452
B-ENT, 2021, vol. 17, num. 4, p. 223-223
https://doi.org/10.5152/B-ENT.2021.21452
dc.rights.none.fl_str_mv cc by (c) Rompaey, Vincent Van et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Rompaey, Vincent Van et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv AVES Publishing Co.
publisher.none.fl_str_mv AVES Publishing Co.
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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