Green production of cladribine by using immobilized 2'-deoxyribosyltransferase from Lactobacillus delbrueckii stabilized through a double covalent/entrapment Technology

Nowadays, enzyme-mediated processes offer an eco-friendly and efficient alternative to the traditional multistep and environmentally harmful chemical processes. Herein we report the enzymatic synthesis of cladribine by a novel 2′-deoxyribosyltransferase (NDT)-based combined biocatalyst. To this end,...

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Detalles Bibliográficos
Autores: Rivero, Cintia Wanda, García, Natalia Soledad, Fernández Lucas, Jesús, Betancor, Lorena, Romanelli, Gustavo Pablo, Trelles, Jorge Abel
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/109033
Acceso en línea:https://hdl.handle.net/20.500.14352/109033
Access Level:acceso abierto
Palabra clave:577.15
577.2
60
615.012
Biomimetic silica
Enzyme immobilization
Glutaraldehyde
Entrapment
Calcium alginate
Antineoplastic drug
Bioquímica (Biología)
Biología molecular (Biología)
Medicamentos
Biotecnología
2403 Bioquímica
2415 Biología Molecular
2302.09 Enzimología
3209.08 Preparación de Medicamentos
Descripción
Sumario:Nowadays, enzyme-mediated processes offer an eco-friendly and efficient alternative to the traditional multistep and environmentally harmful chemical processes. Herein we report the enzymatic synthesis of cladribine by a novel 2′-deoxyribosyltransferase (NDT)-based combined biocatalyst. To this end, Lactobacillus delbrueckii NDT (LdNDT) was successfully immobilized through a two-step immobilization methodology, including a covalent immobilization onto glutaraldehyde-activated biomimetic silica nanoparticles followed by biocatalyst entrapment in calcium alginate. The resulting immobilized derivative, SiGPEI 25000-LdNDT-Alg, displayed 98% retained activity and was shown to be active and stable in a broad range of pH (5–9) and temperature (30–60 °C), but also displayed an extremely high reusability (up to 2100 reuses without negligible loss of activity) in the enzymatic production of cladribine. Finally, as a proof of concept, SiGPEI 25000-LdNDT-Alg was successfully employed in the green production of cladribine at mg scale.