Lipid transport and metabolism in healthy and osteoarthritic cartilage

Cartilage is an avascular tissue and cartilage metabolism depends on molecule diffusion from synovial fluid and subchondral bone. Thus, nutrient availability is limited by matrix permeability according to the size and charge of the molecules. Matrix composition limits the access of molecules to chon...

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Detalles Bibliográficos
Autores: Villalvilla, Amanda, Gómez, Rodolfo, Largo, Raquel, Herrero-Beaumont Cuenca, Gabriel
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/668654
Acceso en línea:http://hdl.handle.net/10486/668654
https://dx.doi.org/10.3390/ijms141020793
Access Level:acceso abierto
Palabra clave:Cartilage
Cholesterol
Chondrocyte
Lipid
Nutrition
Osteoarthritis
Medicina
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spelling Lipid transport and metabolism in healthy and osteoarthritic cartilageVillalvilla, AmandaGómez, RodolfoLargo, RaquelHerrero-Beaumont Cuenca, GabrielCartilageCholesterolChondrocyteLipidNutritionOsteoarthritisMedicinaCartilage is an avascular tissue and cartilage metabolism depends on molecule diffusion from synovial fluid and subchondral bone. Thus, nutrient availability is limited by matrix permeability according to the size and charge of the molecules. Matrix composition limits the access of molecules to chondrocytes, determining cell metabolism and cartilage maintenance. Lipids are important nutrients in chondrocyte metabolism and are available for these cells through de novo synthesis but also through diffusion from surrounding tissues. Cartilage status and osteoarthritis development depend on lipid availability. This paper reviews lipid transport and metabolism in cartilage. We also analyze signalling pathways directly mediated by lipids and those that involve mTOR pathways, both in normal and osteoarthritic cartilageThis work was supported by research grants from Fondo de Investigación Sanitaria (FIS) (PS09/01625 and PI12/00144). Amanda Villalvilla is the recipient of a fellowship from the Fundación Conchita Rábago. Rodolfo Gómez is the recipient of a Sara Borrell contract from FIS. Raquel Largo’s work was funded by the Instituto de Salud Carlos III through a research staff stabilization programMDPI AGDepartamento de MedicinaFacultad de Medicina20132013-10-16research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/668654https://dx.doi.org/10.3390/ijms141020793reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6686542026-06-23T12:46:27Z
dc.title.none.fl_str_mv Lipid transport and metabolism in healthy and osteoarthritic cartilage
title Lipid transport and metabolism in healthy and osteoarthritic cartilage
spellingShingle Lipid transport and metabolism in healthy and osteoarthritic cartilage
Villalvilla, Amanda
Cartilage
Cholesterol
Chondrocyte
Lipid
Nutrition
Osteoarthritis
Medicina
title_short Lipid transport and metabolism in healthy and osteoarthritic cartilage
title_full Lipid transport and metabolism in healthy and osteoarthritic cartilage
title_fullStr Lipid transport and metabolism in healthy and osteoarthritic cartilage
title_full_unstemmed Lipid transport and metabolism in healthy and osteoarthritic cartilage
title_sort Lipid transport and metabolism in healthy and osteoarthritic cartilage
dc.creator.none.fl_str_mv Villalvilla, Amanda
Gómez, Rodolfo
Largo, Raquel
Herrero-Beaumont Cuenca, Gabriel
author Villalvilla, Amanda
author_facet Villalvilla, Amanda
Gómez, Rodolfo
Largo, Raquel
Herrero-Beaumont Cuenca, Gabriel
author_role author
author2 Gómez, Rodolfo
Largo, Raquel
Herrero-Beaumont Cuenca, Gabriel
author2_role author
author
author
dc.contributor.none.fl_str_mv Departamento de Medicina
Facultad de Medicina
dc.subject.none.fl_str_mv Cartilage
Cholesterol
Chondrocyte
Lipid
Nutrition
Osteoarthritis
Medicina
topic Cartilage
Cholesterol
Chondrocyte
Lipid
Nutrition
Osteoarthritis
Medicina
description Cartilage is an avascular tissue and cartilage metabolism depends on molecule diffusion from synovial fluid and subchondral bone. Thus, nutrient availability is limited by matrix permeability according to the size and charge of the molecules. Matrix composition limits the access of molecules to chondrocytes, determining cell metabolism and cartilage maintenance. Lipids are important nutrients in chondrocyte metabolism and are available for these cells through de novo synthesis but also through diffusion from surrounding tissues. Cartilage status and osteoarthritis development depend on lipid availability. This paper reviews lipid transport and metabolism in cartilage. We also analyze signalling pathways directly mediated by lipids and those that involve mTOR pathways, both in normal and osteoarthritic cartilage
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-10-16
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/668654
https://dx.doi.org/10.3390/ijms141020793
url http://hdl.handle.net/10486/668654
https://dx.doi.org/10.3390/ijms141020793
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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