Calcium phosphate cements: Optimization toward biodegradability

Synthetic calcium phosphate (CaP) ceramics represent the most widely used biomaterials for bone regenerative treatments due to their biological performance that is characterized by bioactivity and osteoconductive properties. From a clinical perspective, injectable CaP cements (CPCs) are highly appea...

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Autores: Lodoso Torrecilla, Irene|||0000-0003-1849-5243, van den Beucken, Jeroen J.J.P., Jansen, John A.
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/336280
Acceso en línea:https://hdl.handle.net/2117/336280
https://dx.doi.org/10.1016/j.actbio.2020.10.013
Access Level:acceso abierto
Palabra clave:Bone cements
Tissue engineering
Calcium phosphate
Calcium phosphate cements
Degradation
Macroporosity
Ciments ossis
Enginyeria de teixits
Fosfat de calci
Àrees temàtiques de la UPC::Enginyeria dels materials
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spelling Calcium phosphate cements: Optimization toward biodegradabilityLodoso Torrecilla, Irene|||0000-0003-1849-5243van den Beucken, Jeroen J.J.P.Jansen, John A.Bone cementsTissue engineeringCalcium phosphateCalcium phosphate cementsDegradationMacroporosityCiments ossisEnginyeria de teixitsFosfat de calciÀrees temàtiques de la UPC::Enginyeria dels materialsSynthetic calcium phosphate (CaP) ceramics represent the most widely used biomaterials for bone regenerative treatments due to their biological performance that is characterized by bioactivity and osteoconductive properties. From a clinical perspective, injectable CaP cements (CPCs) are highly appealing, as CPCs can be applied using minimally invasive surgery and can be molded to optimally fill irregular bone defects. Such CPCs are prepared from a powder and a liquid component, which upon mixing form a paste that can be injected into a bone defect and hardens in situ within an appropriate clinical time window. However, a major drawback of CPCs is their poor degradability. Ideally, CPCs should degrade at a suitable pace to allow for concomitant new bone to form. To overcome this shortcoming, control over CPC degradation has been explored using multiple approaches that introduce macroporosity within CPCs. This strategy enables faster degradation of CPC by increasing the surface area available to interact with the biological surroundings, leading to accelerated new bone formation. For a comprehensive overview of the path to degradable CPCs, this review presents the experimental procedures followed for their development with specific emphasis on (bio)material properties and biological performance in pre-clinical bone defect models.Peer ReviewedElsevier20202020-01-0120212021-02-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/336280https://dx.doi.org/10.1016/j.actbio.2020.10.013reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivate 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3362802026-05-27T15:37:01Z
dc.title.none.fl_str_mv Calcium phosphate cements: Optimization toward biodegradability
title Calcium phosphate cements: Optimization toward biodegradability
spellingShingle Calcium phosphate cements: Optimization toward biodegradability
Lodoso Torrecilla, Irene|||0000-0003-1849-5243
Bone cements
Tissue engineering
Calcium phosphate
Calcium phosphate cements
Degradation
Macroporosity
Ciments ossis
Enginyeria de teixits
Fosfat de calci
Àrees temàtiques de la UPC::Enginyeria dels materials
title_short Calcium phosphate cements: Optimization toward biodegradability
title_full Calcium phosphate cements: Optimization toward biodegradability
title_fullStr Calcium phosphate cements: Optimization toward biodegradability
title_full_unstemmed Calcium phosphate cements: Optimization toward biodegradability
title_sort Calcium phosphate cements: Optimization toward biodegradability
dc.creator.none.fl_str_mv Lodoso Torrecilla, Irene|||0000-0003-1849-5243
van den Beucken, Jeroen J.J.P.
Jansen, John A.
author Lodoso Torrecilla, Irene|||0000-0003-1849-5243
author_facet Lodoso Torrecilla, Irene|||0000-0003-1849-5243
van den Beucken, Jeroen J.J.P.
Jansen, John A.
author_role author
author2 van den Beucken, Jeroen J.J.P.
Jansen, John A.
author2_role author
author
dc.subject.none.fl_str_mv Bone cements
Tissue engineering
Calcium phosphate
Calcium phosphate cements
Degradation
Macroporosity
Ciments ossis
Enginyeria de teixits
Fosfat de calci
Àrees temàtiques de la UPC::Enginyeria dels materials
topic Bone cements
Tissue engineering
Calcium phosphate
Calcium phosphate cements
Degradation
Macroporosity
Ciments ossis
Enginyeria de teixits
Fosfat de calci
Àrees temàtiques de la UPC::Enginyeria dels materials
description Synthetic calcium phosphate (CaP) ceramics represent the most widely used biomaterials for bone regenerative treatments due to their biological performance that is characterized by bioactivity and osteoconductive properties. From a clinical perspective, injectable CaP cements (CPCs) are highly appealing, as CPCs can be applied using minimally invasive surgery and can be molded to optimally fill irregular bone defects. Such CPCs are prepared from a powder and a liquid component, which upon mixing form a paste that can be injected into a bone defect and hardens in situ within an appropriate clinical time window. However, a major drawback of CPCs is their poor degradability. Ideally, CPCs should degrade at a suitable pace to allow for concomitant new bone to form. To overcome this shortcoming, control over CPC degradation has been explored using multiple approaches that introduce macroporosity within CPCs. This strategy enables faster degradation of CPC by increasing the surface area available to interact with the biological surroundings, leading to accelerated new bone formation. For a comprehensive overview of the path to degradable CPCs, this review presents the experimental procedures followed for their development with specific emphasis on (bio)material properties and biological performance in pre-clinical bone defect models.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
2021
2021-02-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/336280
https://dx.doi.org/10.1016/j.actbio.2020.10.013
url https://hdl.handle.net/2117/336280
https://dx.doi.org/10.1016/j.actbio.2020.10.013
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivate 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivate 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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