| Sumario: | Machine devices have been around since the early days of organ preservation. Recently, James Southard [1] explained the efforts and troubles that Folkert Belzer had in shipping a kidney recovered in San Francisco (USA), to Leiden (NL), which was thus the first successful "intercontinental" kidney transplant. Currently, we have machine devices for different organs as well as promising dynamic preservation strategies for graft preservation, such as hypothermic oxygenated perfusion (HOPE), allowing us to avoid the graft troubles of Folkert Belzer. We read with great interest the latest article by Andrea Schlegel et al. [2] in EBioMedicine. In it, the authors use HOPE to establish beneficial biochemical mechanisms, by restoring mitochondrial function through succinate metabolism and prevention of energy breakdown. Notably, the presence of succinate alone already plays a decisive role when comparing HOPE to static hypothermic preservation and other dynamic normothermic / sub-normothermic ones.
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