Cognitive impairment with Type 2 Diabetes Mellitus among older adults in Chile: prevalence, risk factors and cognitive characteristics

Introduction: The aim of this study is to determine prevalence and risk factors of Cognitive Impairment (CI) and its association with Type 2 Diabetes Mellitus (T2DM) in subjects aged 65 years and above. Additionally, we attempt to provide a cognitive profile for T2DM group. Methodology: A cross-sect...

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Authors: Bozanic Leal, Agnieszka, Toro Espinoza, Pablo, Bello-Lepe, Sebastián, Hurtado-Oliva, Javier, Beyle, Christian, Valdés, Catalina, Formiga Pérez, Francesc
Format: article
Status:Published version
Publication Date:2023
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/192472
Online Access:https://hdl.handle.net/2445/192472
Access Level:Open access
Keyword:Diabetis
Factors de risc en les malalties
Demència senil
Diabetes
Risk factors in diseases
Senile dementia
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spelling Cognitive impairment with Type 2 Diabetes Mellitus among older adults in Chile: prevalence, risk factors and cognitive characteristicsBozanic Leal, AgnieszkaToro Espinoza, PabloBello-Lepe, SebastiánHurtado-Oliva, JavierBeyle, ChristianValdés, CatalinaFormiga Pérez, FrancescDiabetisFactors de risc en les malaltiesDemència senilDiabetesRisk factors in diseasesSenile dementiaIntroduction: The aim of this study is to determine prevalence and risk factors of Cognitive Impairment (CI) and its association with Type 2 Diabetes Mellitus (T2DM) in subjects aged 65 years and above. Additionally, we attempt to provide a cognitive profile for T2DM group. Methodology: A cross-sectional analytical study to assess CI was carried out. We evaluated a sample of community-dwelling residents from Chile. All participants underwent a general interview, lifestyle questionnaires and a comprehensive neuropsychological battery. Regression analyses were performed to evaluate risk of CI with T2DM and influencing factors. Results between groups in the different domains of the neuropsychological assessment were compared by Student's t-tests and MANOVA. Results: Among all 358 subjects, overall T2DM prevalence were 17.3%. The prevalence of CI was higher in T2DM group compared to the healthy participants (30.7%, p < 0.001). The risk of CI was 2.8 times higher in older people with T2DM compared to older people without the diagnosis. Multiple regression analysis, adjusted for age and gender, demonstrated that age, education, presence of dyslipidemia, and T2DM duration were the predictor variables significantly associated with CI. T2DM group performed worse on global cognitive performance, attention, language, verbal memory, visual memory, visual constructional ability, and executive function. After adjusting for significant covariates from multiple regression analysis, a relationship between "cognition" and T2DM is still observed. Amnesic multi-domain impairment was the specific cognitive identified pattern for T2DM group. Conclusion: The present study confirms the high prevalence of CI with T2DM among Chilean older adults in a community-based population. T2DM is significantly associated with a higher risk of CI, and age, education, presence of dyslipidemia, and duration of T2DM are risk factors. T2DM patients with CI are impaired in multiple cognitive domains, even after adjusting covariables, resulting in an amnesic multi-domain cognitive profile.Frontiers Media2023202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/192472Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fnhum.2022.1070611Frontiers in Human Neuroscience, 2023, vol. 16https://doi.org/10.3389/fnhum.2022.1070611cc-by (c) Bozanic Leal, Agnieszka et al., 2023https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1924722026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cognitive impairment with Type 2 Diabetes Mellitus among older adults in Chile: prevalence, risk factors and cognitive characteristics
title Cognitive impairment with Type 2 Diabetes Mellitus among older adults in Chile: prevalence, risk factors and cognitive characteristics
spellingShingle Cognitive impairment with Type 2 Diabetes Mellitus among older adults in Chile: prevalence, risk factors and cognitive characteristics
Bozanic Leal, Agnieszka
Diabetis
Factors de risc en les malalties
Demència senil
Diabetes
Risk factors in diseases
Senile dementia
title_short Cognitive impairment with Type 2 Diabetes Mellitus among older adults in Chile: prevalence, risk factors and cognitive characteristics
title_full Cognitive impairment with Type 2 Diabetes Mellitus among older adults in Chile: prevalence, risk factors and cognitive characteristics
title_fullStr Cognitive impairment with Type 2 Diabetes Mellitus among older adults in Chile: prevalence, risk factors and cognitive characteristics
title_full_unstemmed Cognitive impairment with Type 2 Diabetes Mellitus among older adults in Chile: prevalence, risk factors and cognitive characteristics
title_sort Cognitive impairment with Type 2 Diabetes Mellitus among older adults in Chile: prevalence, risk factors and cognitive characteristics
dc.creator.none.fl_str_mv Bozanic Leal, Agnieszka
Toro Espinoza, Pablo
Bello-Lepe, Sebastián
Hurtado-Oliva, Javier
Beyle, Christian
Valdés, Catalina
Formiga Pérez, Francesc
author Bozanic Leal, Agnieszka
author_facet Bozanic Leal, Agnieszka
Toro Espinoza, Pablo
Bello-Lepe, Sebastián
Hurtado-Oliva, Javier
Beyle, Christian
Valdés, Catalina
Formiga Pérez, Francesc
author_role author
author2 Toro Espinoza, Pablo
Bello-Lepe, Sebastián
Hurtado-Oliva, Javier
Beyle, Christian
Valdés, Catalina
Formiga Pérez, Francesc
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Diabetis
Factors de risc en les malalties
Demència senil
Diabetes
Risk factors in diseases
Senile dementia
topic Diabetis
Factors de risc en les malalties
Demència senil
Diabetes
Risk factors in diseases
Senile dementia
description Introduction: The aim of this study is to determine prevalence and risk factors of Cognitive Impairment (CI) and its association with Type 2 Diabetes Mellitus (T2DM) in subjects aged 65 years and above. Additionally, we attempt to provide a cognitive profile for T2DM group. Methodology: A cross-sectional analytical study to assess CI was carried out. We evaluated a sample of community-dwelling residents from Chile. All participants underwent a general interview, lifestyle questionnaires and a comprehensive neuropsychological battery. Regression analyses were performed to evaluate risk of CI with T2DM and influencing factors. Results between groups in the different domains of the neuropsychological assessment were compared by Student's t-tests and MANOVA. Results: Among all 358 subjects, overall T2DM prevalence were 17.3%. The prevalence of CI was higher in T2DM group compared to the healthy participants (30.7%, p < 0.001). The risk of CI was 2.8 times higher in older people with T2DM compared to older people without the diagnosis. Multiple regression analysis, adjusted for age and gender, demonstrated that age, education, presence of dyslipidemia, and T2DM duration were the predictor variables significantly associated with CI. T2DM group performed worse on global cognitive performance, attention, language, verbal memory, visual memory, visual constructional ability, and executive function. After adjusting for significant covariates from multiple regression analysis, a relationship between "cognition" and T2DM is still observed. Amnesic multi-domain impairment was the specific cognitive identified pattern for T2DM group. Conclusion: The present study confirms the high prevalence of CI with T2DM among Chilean older adults in a community-based population. T2DM is significantly associated with a higher risk of CI, and age, education, presence of dyslipidemia, and duration of T2DM are risk factors. T2DM patients with CI are impaired in multiple cognitive domains, even after adjusting covariables, resulting in an amnesic multi-domain cognitive profile.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/192472
url https://hdl.handle.net/2445/192472
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fnhum.2022.1070611
Frontiers in Human Neuroscience, 2023, vol. 16
https://doi.org/10.3389/fnhum.2022.1070611
dc.rights.none.fl_str_mv cc-by (c) Bozanic Leal, Agnieszka et al., 2023
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Bozanic Leal, Agnieszka et al., 2023
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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