Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding

Feed efficiency (FE) is one of the most economically and environmentally relevant traits in the animal production sector. The objective of this study was to gain knowledge about the genetic control of FE in rabbits. To this end, GWASs were conducted for individual growth under two feeding regimes (f...

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Autores: Sánchez, Juan Pablo|||0000-0001-8639-6146, Legarra, Andres, Velasco-Galilea, M., Piles, Miriam|||0000-0001-8265-9930, Sánchez Bonastre, Armando|||0000-0001-9160-1124, Rafel Guarro, Oriol, González-Rodríguez, Olga, Ballester Devis, Maria|||0000-0002-5413-4640
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:236999
Acceso en línea:https://ddd.uab.cat/record/236999
https://dx.doi.org/urn:doi:10.1111/age.12988
Access Level:acceso abierto
Palabra clave:Candidate gene
Feed efficiency
Genome-wide association study
Growth
Pooled records
Rabbit
Restricted feeding
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spelling Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feedingSánchez, Juan Pablo|||0000-0001-8639-6146Legarra, AndresVelasco-Galilea, M.Piles, Miriam|||0000-0001-8265-9930Sánchez Bonastre, Armando|||0000-0001-9160-1124Rafel Guarro, OriolGonzález-Rodríguez, OlgaBallester Devis, Maria|||0000-0002-5413-4640Candidate geneFeed efficiencyGenome-wide association studyGrowthPooled recordsRabbitRestricted feedingFeed efficiency (FE) is one of the most economically and environmentally relevant traits in the animal production sector. The objective of this study was to gain knowledge about the genetic control of FE in rabbits. To this end, GWASs were conducted for individual growth under two feeding regimes (full feeding and restricted) and FE traits collected from cage groups, using 114 604 autosome SNPs segregating in 438 rabbits. Two different models were implemented: (1) an animal model with a linear regression on each SNP allele for growth trait; and (2) a two-trait animal model, jointly fitting the performance trait and each SNP allele content, for FE traits. This last modeling strategy is a new tool applied to GWAS and allows information to be considered from non-genotyped individuals whose contribution is relevant in the group average traits. A total of 189 SNPs in 17 chromosomal regions were declared to be significantly associated with any of the five analyzed traits at a chromosome-wide level. In 12 of these regions, 20 candidate genes were proposed to explain the variation of the analyzed traits, including genes such as FTO, NDUFAF6 and CEBPA previously associated with growth and FE traits in monogastric species. Candidate genes associated with behavioral patterns were also identified. Overall, our results can be considered as the foundation for future functional research to unravel the actual causal mutations regulating growth and FE in rabbits. 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/236999https://dx.doi.org/urn:doi:10.1111/age.12988reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Commission https://doi.org/10.13039/501100000780 63353Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 RTA2014-00015-C2-01Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 RTA2011-00064-00-00Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 RTI2018-097610-R-I00Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RYC/2013-12573open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2369992026-06-06T12:50:31Z
dc.title.none.fl_str_mv Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding
title Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding
spellingShingle Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding
Sánchez, Juan Pablo|||0000-0001-8639-6146
Candidate gene
Feed efficiency
Genome-wide association study
Growth
Pooled records
Rabbit
Restricted feeding
title_short Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding
title_full Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding
title_fullStr Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding
title_full_unstemmed Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding
title_sort Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding
dc.creator.none.fl_str_mv Sánchez, Juan Pablo|||0000-0001-8639-6146
Legarra, Andres
Velasco-Galilea, M.
Piles, Miriam|||0000-0001-8265-9930
Sánchez Bonastre, Armando|||0000-0001-9160-1124
Rafel Guarro, Oriol
González-Rodríguez, Olga
Ballester Devis, Maria|||0000-0002-5413-4640
author Sánchez, Juan Pablo|||0000-0001-8639-6146
author_facet Sánchez, Juan Pablo|||0000-0001-8639-6146
Legarra, Andres
Velasco-Galilea, M.
Piles, Miriam|||0000-0001-8265-9930
Sánchez Bonastre, Armando|||0000-0001-9160-1124
Rafel Guarro, Oriol
González-Rodríguez, Olga
Ballester Devis, Maria|||0000-0002-5413-4640
author_role author
author2 Legarra, Andres
Velasco-Galilea, M.
Piles, Miriam|||0000-0001-8265-9930
Sánchez Bonastre, Armando|||0000-0001-9160-1124
Rafel Guarro, Oriol
González-Rodríguez, Olga
Ballester Devis, Maria|||0000-0002-5413-4640
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Candidate gene
Feed efficiency
Genome-wide association study
Growth
Pooled records
Rabbit
Restricted feeding
topic Candidate gene
Feed efficiency
Genome-wide association study
Growth
Pooled records
Rabbit
Restricted feeding
description Feed efficiency (FE) is one of the most economically and environmentally relevant traits in the animal production sector. The objective of this study was to gain knowledge about the genetic control of FE in rabbits. To this end, GWASs were conducted for individual growth under two feeding regimes (full feeding and restricted) and FE traits collected from cage groups, using 114 604 autosome SNPs segregating in 438 rabbits. Two different models were implemented: (1) an animal model with a linear regression on each SNP allele for growth trait; and (2) a two-trait animal model, jointly fitting the performance trait and each SNP allele content, for FE traits. This last modeling strategy is a new tool applied to GWAS and allows information to be considered from non-genotyped individuals whose contribution is relevant in the group average traits. A total of 189 SNPs in 17 chromosomal regions were declared to be significantly associated with any of the five analyzed traits at a chromosome-wide level. In 12 of these regions, 20 candidate genes were proposed to explain the variation of the analyzed traits, including genes such as FTO, NDUFAF6 and CEBPA previously associated with growth and FE traits in monogastric species. Candidate genes associated with behavioral patterns were also identified. Overall, our results can be considered as the foundation for future functional research to unravel the actual causal mutations regulating growth and FE in rabbits.
publishDate 2020
dc.date.none.fl_str_mv 2
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/236999
https://dx.doi.org/urn:doi:10.1111/age.12988
url https://ddd.uab.cat/record/236999
https://dx.doi.org/urn:doi:10.1111/age.12988
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission https://doi.org/10.13039/501100000780 63353
Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 RTA2014-00015-C2-01
Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 RTA2011-00064-00-00
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 RTI2018-097610-R-I00
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RYC/2013-12573
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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