Association between Adverse Childhood Experiences and long-term outcomes in people at Clinical High-Risk for Psychosis

Tognin, Stefania|||0000-0002-1983-9135; Catalan, Ana|||0000-0002-0418-7904; Aymerich, Claudia|||0000-0003-0040-1608; Richter, Anja|||0000-0002-0253-6111; Kempton, Matthew|||0000-0003-3541-9947; Modinos, Gemma|||0000-0002-7870-066X; Hammoud, Ryan|||0000-0002-0848-0753; Gorostiza, Iñigo|||0000-0001-5896-6148; Vassos, Evangelos|||0000-0001-6363-0438; Gaag, Mark van der, 1953-|||0000-0002-3525-6415; Haan, Lieuwe de, 1960-|||0000-0002-3820-7926; Nelson, Barnaby|||0000-0002-6263-2332; Riecher-Rössler, Anita|||0000-0001-6361-8789; Bressan, Rodrigo Affonseca|||0000-0002-0868-4449; Barrantes Vidal, Neus|||0000-0002-8671-1238; Krebs, Marie Odile|||0000-0002-4715-9890; Nordentoft, Merete|||0000-0003-4895-7023; Ruhrmann, Stephan|||0000-0002-6022-2364; Sachs, Gabriele|||0000-0002-8359-9877; Rutten, Bart P. F.|||0000-0002-9834-6346; Valmaggia, Lucia|||0000-0001-6099-8464; McGuire, Philip|||0000-0003-4381-0532

Association between Adverse Childhood Experiences and long-term outcomes in people at Clinical High-Risk for Psychosis

Adverse childhood experiences (ACEs) are common in people at clinical high-risk for psychosis (CHR), however, the relationship between ACEs and long-term clinical outcomes is still unclear. This study examined associations between ACEs and clinical outcomes in CHR individuals. 344 CHR individuals an...

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Autores:	Tognin, Stefania\|\|\|0000-0002-1983-9135, Catalan, Ana\|\|\|0000-0002-0418-7904, Aymerich, Claudia\|\|\|0000-0003-0040-1608, Richter, Anja\|\|\|0000-0002-0253-6111, Kempton, Matthew\|\|\|0000-0003-3541-9947, Modinos, Gemma\|\|\|0000-0002-7870-066X, Hammoud, Ryan\|\|\|0000-0002-0848-0753, Gorostiza, Iñigo\|\|\|0000-0001-5896-6148, Vassos, Evangelos\|\|\|0000-0001-6363-0438, Gaag, Mark van der, 1953-\|\|\|0000-0002-3525-6415, Haan, Lieuwe de, 1960-\|\|\|0000-0002-3820-7926, Nelson, Barnaby\|\|\|0000-0002-6263-2332, Riecher-Rössler, Anita\|\|\|0000-0001-6361-8789, Bressan, Rodrigo Affonseca\|\|\|0000-0002-0868-4449, Barrantes Vidal, Neus\|\|\|0000-0002-8671-1238, Krebs, Marie Odile\|\|\|0000-0002-4715-9890, Nordentoft, Merete\|\|\|0000-0003-4895-7023, Ruhrmann, Stephan\|\|\|0000-0002-6022-2364, Sachs, Gabriele\|\|\|0000-0002-8359-9877, Rutten, Bart P. F.\|\|\|0000-0002-9834-6346, Valmaggia, Lucia\|\|\|0000-0001-6099-8464, McGuire, Philip\|\|\|0000-0003-4381-0532
Tipo de recurso:	artículo
Fecha de publicación:	2025
País:	España
Institución:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:ddd.uab.cat:318322
Acceso en línea:	https://ddd.uab.cat/record/318322 https://dx.doi.org/urn:doi:10.1038/s41537-025-00562-9
Access Level:	acceso abierto
Palabra clave:	Psychosis Adverse childhood experiences Long-term clinical outcomes CHR individuals

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spelling	Association between Adverse Childhood Experiences and long-term outcomes in people at Clinical High-Risk for PsychosisTognin, Stefania\|\|\|0000-0002-1983-9135Catalan, Ana\|\|\|0000-0002-0418-7904Aymerich, Claudia\|\|\|0000-0003-0040-1608Richter, Anja\|\|\|0000-0002-0253-6111Kempton, Matthew\|\|\|0000-0003-3541-9947Modinos, Gemma\|\|\|0000-0002-7870-066XHammoud, Ryan\|\|\|0000-0002-0848-0753Gorostiza, Iñigo\|\|\|0000-0001-5896-6148Vassos, Evangelos\|\|\|0000-0001-6363-0438Gaag, Mark van der, 1953-\|\|\|0000-0002-3525-6415Haan, Lieuwe de, 1960-\|\|\|0000-0002-3820-7926Nelson, Barnaby\|\|\|0000-0002-6263-2332Riecher-Rössler, Anita\|\|\|0000-0001-6361-8789Bressan, Rodrigo Affonseca\|\|\|0000-0002-0868-4449Barrantes Vidal, Neus\|\|\|0000-0002-8671-1238Krebs, Marie Odile\|\|\|0000-0002-4715-9890Nordentoft, Merete\|\|\|0000-0003-4895-7023Ruhrmann, Stephan\|\|\|0000-0002-6022-2364Sachs, Gabriele\|\|\|0000-0002-8359-9877Rutten, Bart P. F.\|\|\|0000-0002-9834-6346Valmaggia, Lucia\|\|\|0000-0001-6099-8464McGuire, Philip\|\|\|0000-0003-4381-0532PsychosisAdverse childhood experiencesLong-term clinical outcomesCHR individualsAdverse childhood experiences (ACEs) are common in people at clinical high-risk for psychosis (CHR), however, the relationship between ACEs and long-term clinical outcomes is still unclear. This study examined associations between ACEs and clinical outcomes in CHR individuals. 344 CHR individuals and 67 healthy controls (HC) were assessed using the Childhood Trauma Questionnaire (CTQ), the Bullying Questionnaire and the Childhood Experience of Care and Abuse (CECA). CHR were followed up for up to 5 years. Remission from the CHR state, transition to psychosis (both defined with the Comprehensive Assessment of an At Risk Mental State), and level of functioning (assessed with the Global Assessment of Functioning) were assessed. Stepwise and multilevel logistic regression models were used to investigate the relationship between ACEs and outcomes. ACEs were significantly more prevalent in CHR individuals than in HC. Within the CHR cohort, physical abuse was associated with a reduced likelihood of remission (OR = 3.64, p = 0.025). Separation from a parent was linked to an increased likelihood of both remission (OR = 0.32, p = 0.011) and higher level of functioning (OR = 1.77, p = 0.040). Death of a parent (OR = 1.87, p = 0.037) was associated with an increased risk of transitioning to psychosis. Physical abuse and death of a parent are related to adverse long-term outcomes in CHR. The counter-intuitive association between separation from a parent and outcomes may reflect the removal of a child from an adverse environment. Future studies should investigate whether interventions targeting the effect of specific ACEs might help to improve outcomes in this population. 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/318322https://dx.doi.org/urn:doi:10.1038/s41537-025-00562-9reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PSI2017-87512-C2-1-RAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-119211RB-I00Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-01010open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3183222026-06-06T12:50:31Z
dc.title.none.fl_str_mv	Association between Adverse Childhood Experiences and long-term outcomes in people at Clinical High-Risk for Psychosis
title	Association between Adverse Childhood Experiences and long-term outcomes in people at Clinical High-Risk for Psychosis
spellingShingle	Association between Adverse Childhood Experiences and long-term outcomes in people at Clinical High-Risk for Psychosis Tognin, Stefania\|\|\|0000-0002-1983-9135 Psychosis Adverse childhood experiences Long-term clinical outcomes CHR individuals
title_short	Association between Adverse Childhood Experiences and long-term outcomes in people at Clinical High-Risk for Psychosis
title_full	Association between Adverse Childhood Experiences and long-term outcomes in people at Clinical High-Risk for Psychosis
title_fullStr	Association between Adverse Childhood Experiences and long-term outcomes in people at Clinical High-Risk for Psychosis
title_full_unstemmed	Association between Adverse Childhood Experiences and long-term outcomes in people at Clinical High-Risk for Psychosis
title_sort	Association between Adverse Childhood Experiences and long-term outcomes in people at Clinical High-Risk for Psychosis
dc.creator.none.fl_str_mv	Tognin, Stefania\|\|\|0000-0002-1983-9135 Catalan, Ana\|\|\|0000-0002-0418-7904 Aymerich, Claudia\|\|\|0000-0003-0040-1608 Richter, Anja\|\|\|0000-0002-0253-6111 Kempton, Matthew\|\|\|0000-0003-3541-9947 Modinos, Gemma\|\|\|0000-0002-7870-066X Hammoud, Ryan\|\|\|0000-0002-0848-0753 Gorostiza, Iñigo\|\|\|0000-0001-5896-6148 Vassos, Evangelos\|\|\|0000-0001-6363-0438 Gaag, Mark van der, 1953-\|\|\|0000-0002-3525-6415 Haan, Lieuwe de, 1960-\|\|\|0000-0002-3820-7926 Nelson, Barnaby\|\|\|0000-0002-6263-2332 Riecher-Rössler, Anita\|\|\|0000-0001-6361-8789 Bressan, Rodrigo Affonseca\|\|\|0000-0002-0868-4449 Barrantes Vidal, Neus\|\|\|0000-0002-8671-1238 Krebs, Marie Odile\|\|\|0000-0002-4715-9890 Nordentoft, Merete\|\|\|0000-0003-4895-7023 Ruhrmann, Stephan\|\|\|0000-0002-6022-2364 Sachs, Gabriele\|\|\|0000-0002-8359-9877 Rutten, Bart P. F.\|\|\|0000-0002-9834-6346 Valmaggia, Lucia\|\|\|0000-0001-6099-8464 McGuire, Philip\|\|\|0000-0003-4381-0532
author	Tognin, Stefania\|\|\|0000-0002-1983-9135
author_facet	Tognin, Stefania\|\|\|0000-0002-1983-9135 Catalan, Ana\|\|\|0000-0002-0418-7904 Aymerich, Claudia\|\|\|0000-0003-0040-1608 Richter, Anja\|\|\|0000-0002-0253-6111 Kempton, Matthew\|\|\|0000-0003-3541-9947 Modinos, Gemma\|\|\|0000-0002-7870-066X Hammoud, Ryan\|\|\|0000-0002-0848-0753 Gorostiza, Iñigo\|\|\|0000-0001-5896-6148 Vassos, Evangelos\|\|\|0000-0001-6363-0438 Gaag, Mark van der, 1953-\|\|\|0000-0002-3525-6415 Haan, Lieuwe de, 1960-\|\|\|0000-0002-3820-7926 Nelson, Barnaby\|\|\|0000-0002-6263-2332 Riecher-Rössler, Anita\|\|\|0000-0001-6361-8789 Bressan, Rodrigo Affonseca\|\|\|0000-0002-0868-4449 Barrantes Vidal, Neus\|\|\|0000-0002-8671-1238 Krebs, Marie Odile\|\|\|0000-0002-4715-9890 Nordentoft, Merete\|\|\|0000-0003-4895-7023 Ruhrmann, Stephan\|\|\|0000-0002-6022-2364 Sachs, Gabriele\|\|\|0000-0002-8359-9877 Rutten, Bart P. F.\|\|\|0000-0002-9834-6346 Valmaggia, Lucia\|\|\|0000-0001-6099-8464 McGuire, Philip\|\|\|0000-0003-4381-0532
author_role	author
author2	Catalan, Ana\|\|\|0000-0002-0418-7904 Aymerich, Claudia\|\|\|0000-0003-0040-1608 Richter, Anja\|\|\|0000-0002-0253-6111 Kempton, Matthew\|\|\|0000-0003-3541-9947 Modinos, Gemma\|\|\|0000-0002-7870-066X Hammoud, Ryan\|\|\|0000-0002-0848-0753 Gorostiza, Iñigo\|\|\|0000-0001-5896-6148 Vassos, Evangelos\|\|\|0000-0001-6363-0438 Gaag, Mark van der, 1953-\|\|\|0000-0002-3525-6415 Haan, Lieuwe de, 1960-\|\|\|0000-0002-3820-7926 Nelson, Barnaby\|\|\|0000-0002-6263-2332 Riecher-Rössler, Anita\|\|\|0000-0001-6361-8789 Bressan, Rodrigo Affonseca\|\|\|0000-0002-0868-4449 Barrantes Vidal, Neus\|\|\|0000-0002-8671-1238 Krebs, Marie Odile\|\|\|0000-0002-4715-9890 Nordentoft, Merete\|\|\|0000-0003-4895-7023 Ruhrmann, Stephan\|\|\|0000-0002-6022-2364 Sachs, Gabriele\|\|\|0000-0002-8359-9877 Rutten, Bart P. F.\|\|\|0000-0002-9834-6346 Valmaggia, Lucia\|\|\|0000-0001-6099-8464 McGuire, Philip\|\|\|0000-0003-4381-0532
author2_role	author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Psychosis Adverse childhood experiences Long-term clinical outcomes CHR individuals
topic	Psychosis Adverse childhood experiences Long-term clinical outcomes CHR individuals
description	Adverse childhood experiences (ACEs) are common in people at clinical high-risk for psychosis (CHR), however, the relationship between ACEs and long-term clinical outcomes is still unclear. This study examined associations between ACEs and clinical outcomes in CHR individuals. 344 CHR individuals and 67 healthy controls (HC) were assessed using the Childhood Trauma Questionnaire (CTQ), the Bullying Questionnaire and the Childhood Experience of Care and Abuse (CECA). CHR were followed up for up to 5 years. Remission from the CHR state, transition to psychosis (both defined with the Comprehensive Assessment of an At Risk Mental State), and level of functioning (assessed with the Global Assessment of Functioning) were assessed. Stepwise and multilevel logistic regression models were used to investigate the relationship between ACEs and outcomes. ACEs were significantly more prevalent in CHR individuals than in HC. Within the CHR cohort, physical abuse was associated with a reduced likelihood of remission (OR = 3.64, p = 0.025). Separation from a parent was linked to an increased likelihood of both remission (OR = 0.32, p = 0.011) and higher level of functioning (OR = 1.77, p = 0.040). Death of a parent (OR = 1.87, p = 0.037) was associated with an increased risk of transitioning to psychosis. Physical abuse and death of a parent are related to adverse long-term outcomes in CHR. The counter-intuitive association between separation from a parent and outcomes may reflect the removal of a child from an adverse environment. Future studies should investigate whether interventions targeting the effect of specific ACEs might help to improve outcomes in this population.
publishDate	2025
dc.date.none.fl_str_mv	2 2025-01-01 2025 2025-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/318322 https://dx.doi.org/urn:doi:10.1038/s41537-025-00562-9
url	https://ddd.uab.cat/record/318322 https://dx.doi.org/urn:doi:10.1038/s41537-025-00562-9
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PSI2017-87512-C2-1-R Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-119211RB-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-01010
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
collection	Dipòsit Digital de Documents de la UAB
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Association between Adverse Childhood Experiences and long-term outcomes in people at Clinical High-Risk for Psychosis

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