Clinical features, etiology and outcomes of community-acquired pneumonia in patients with chronic obstructive pulmonary disease

Background Community-acquired pneumonia (CAP) is a frequent complication of chronic obstructive pulmonary disease (COPD), but previous studies are often contradictory. Objectives We aimed to ascertain the characteristics and outcomes of CAP in patients with COPD as well as to determine the risk fact...

Descripción completa

Detalles Bibliográficos
Autores: Gómez Junyent, Joan, Garcia Vidal, Carolina, Viasus, Diego, Millat Martínez, Pere, Simonetti, Antonella Francesca, Santos Pérez, Salud, Ardanuy Tisaire, María Carmen, Dorca i Sargatal, Jordi, Carratalà, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/123840
Acceso en línea:https://hdl.handle.net/2445/123840
Access Level:acceso abierto
Palabra clave:Pneumònia
Malalties pulmonars obstructives cròniques
Etiologia
Pneumonia
Chronic obstructive pulmonary diseases
Etiology
id ES_fc8172cbdd55da9febeeff7325d968f6
oai_identifier_str oai:diposit.ub.edu:2445/123840
network_acronym_str ES
network_name_str España
repository_id_str
spelling Clinical features, etiology and outcomes of community-acquired pneumonia in patients with chronic obstructive pulmonary diseaseGómez Junyent, JoanGarcia Vidal, CarolinaViasus, DiegoMillat Martínez, PereSimonetti, Antonella FrancescaSantos Pérez, SaludArdanuy Tisaire, María CarmenDorca i Sargatal, JordiCarratalà, JordiPneumòniaMalalties pulmonars obstructives cròniquesEtiologiaPneumoniaChronic obstructive pulmonary diseasesEtiologyBackground Community-acquired pneumonia (CAP) is a frequent complication of chronic obstructive pulmonary disease (COPD), but previous studies are often contradictory. Objectives We aimed to ascertain the characteristics and outcomes of CAP in patients with COPD as well as to determine the risk factors for mortality and Pseudomonas aeruginosa pneumonia in COPD patients with CAP. We also describe the etiology and outcomes of CAP in COPD patients receiving chronic oxygen therapy at home and those receiving inhaled steroids. Methods An observational analysis of a prospective cohort of hospitalized adults with CAP (1995-2011) was performed. Results We documented 4121 CAP episodes, of which 983 (23.9%) occurred in patients with COPD; the median FEV1 value was 50%, and 57.8% were classified as stage III or IV in the GOLD classification. Fifty-eight per cent of patients were receiving inhaled steroids, and 14.6% chronic oxygen therapy at home. Patients with COPD presented specific clinical features. S. pneumoniae was the leading causative organism overall, but P. aeruginosa was more frequent in COPD (3.4 vs. 0.5%; p<0.001). Independent risk factors for case-fatality rate in patients with COPD were multilobar pneumonia, P. aeruginosa pneumonia, and high-risk PSI classes. Prior pneumococcal vaccination was found to be protective. FEV1 was an independent risk factor for P. aeruginosa pneumonia. Conclusions CAP in patients with COPD presents specific characteristics and risk factors for mortality. Prior pneumococcal vaccine has a beneficial effect on outcomes. P. aeruginosa pneumonia is associated with low FEV1 values and poor prognosis.Public Library of Science (PLoS)2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/123840Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0105854PLoS One, 2014, vol. 9, num. 8, p. 1-10https://doi.org/10.1371/journal.pone.0105854cc-by (c) Gómez-Junyent, Joan et al., 2014http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1238402026-05-27T06:46:51Z
dc.title.none.fl_str_mv Clinical features, etiology and outcomes of community-acquired pneumonia in patients with chronic obstructive pulmonary disease
title Clinical features, etiology and outcomes of community-acquired pneumonia in patients with chronic obstructive pulmonary disease
spellingShingle Clinical features, etiology and outcomes of community-acquired pneumonia in patients with chronic obstructive pulmonary disease
Gómez Junyent, Joan
Pneumònia
Malalties pulmonars obstructives cròniques
Etiologia
Pneumonia
Chronic obstructive pulmonary diseases
Etiology
title_short Clinical features, etiology and outcomes of community-acquired pneumonia in patients with chronic obstructive pulmonary disease
title_full Clinical features, etiology and outcomes of community-acquired pneumonia in patients with chronic obstructive pulmonary disease
title_fullStr Clinical features, etiology and outcomes of community-acquired pneumonia in patients with chronic obstructive pulmonary disease
title_full_unstemmed Clinical features, etiology and outcomes of community-acquired pneumonia in patients with chronic obstructive pulmonary disease
title_sort Clinical features, etiology and outcomes of community-acquired pneumonia in patients with chronic obstructive pulmonary disease
dc.creator.none.fl_str_mv Gómez Junyent, Joan
Garcia Vidal, Carolina
Viasus, Diego
Millat Martínez, Pere
Simonetti, Antonella Francesca
Santos Pérez, Salud
Ardanuy Tisaire, María Carmen
Dorca i Sargatal, Jordi
Carratalà, Jordi
author Gómez Junyent, Joan
author_facet Gómez Junyent, Joan
Garcia Vidal, Carolina
Viasus, Diego
Millat Martínez, Pere
Simonetti, Antonella Francesca
Santos Pérez, Salud
Ardanuy Tisaire, María Carmen
Dorca i Sargatal, Jordi
Carratalà, Jordi
author_role author
author2 Garcia Vidal, Carolina
Viasus, Diego
Millat Martínez, Pere
Simonetti, Antonella Francesca
Santos Pérez, Salud
Ardanuy Tisaire, María Carmen
Dorca i Sargatal, Jordi
Carratalà, Jordi
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pneumònia
Malalties pulmonars obstructives cròniques
Etiologia
Pneumonia
Chronic obstructive pulmonary diseases
Etiology
topic Pneumònia
Malalties pulmonars obstructives cròniques
Etiologia
Pneumonia
Chronic obstructive pulmonary diseases
Etiology
description Background Community-acquired pneumonia (CAP) is a frequent complication of chronic obstructive pulmonary disease (COPD), but previous studies are often contradictory. Objectives We aimed to ascertain the characteristics and outcomes of CAP in patients with COPD as well as to determine the risk factors for mortality and Pseudomonas aeruginosa pneumonia in COPD patients with CAP. We also describe the etiology and outcomes of CAP in COPD patients receiving chronic oxygen therapy at home and those receiving inhaled steroids. Methods An observational analysis of a prospective cohort of hospitalized adults with CAP (1995-2011) was performed. Results We documented 4121 CAP episodes, of which 983 (23.9%) occurred in patients with COPD; the median FEV1 value was 50%, and 57.8% were classified as stage III or IV in the GOLD classification. Fifty-eight per cent of patients were receiving inhaled steroids, and 14.6% chronic oxygen therapy at home. Patients with COPD presented specific clinical features. S. pneumoniae was the leading causative organism overall, but P. aeruginosa was more frequent in COPD (3.4 vs. 0.5%; p<0.001). Independent risk factors for case-fatality rate in patients with COPD were multilobar pneumonia, P. aeruginosa pneumonia, and high-risk PSI classes. Prior pneumococcal vaccination was found to be protective. FEV1 was an independent risk factor for P. aeruginosa pneumonia. Conclusions CAP in patients with COPD presents specific characteristics and risk factors for mortality. Prior pneumococcal vaccine has a beneficial effect on outcomes. P. aeruginosa pneumonia is associated with low FEV1 values and poor prognosis.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/123840
url https://hdl.handle.net/2445/123840
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0105854
PLoS One, 2014, vol. 9, num. 8, p. 1-10
https://doi.org/10.1371/journal.pone.0105854
dc.rights.none.fl_str_mv cc-by (c) Gómez-Junyent, Joan et al., 2014
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Gómez-Junyent, Joan et al., 2014
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869425428887764992
score 15,298079

Similares en LA Referencia