Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C): A multicenter, retrospective study

Most children and adolescents infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain asymptomatic or develop a mild coronavirus disease 2019 (COVID-19) that usually does not require medical intervention. However, a small proportion of pediatric patients develop a sever...

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Autores: Davalos, Veronica, García-Prieto, Carlos A., Ferrer, Gerardo, Aguilera-Albesa, Sergio, Valencia Ramos, Juan, Rodríguez-Palmero, Agustí, Ruiz, Montserrat, Planas-Serra, Laura, Jordan, Iolanda, Alegría, Iosune, Flores-Pérez, Patricia, Cantarín, Verónica, Fumadó, Victoria, Viadero, Maria Teresa, Rodrigo, Carlos, Méndez-Hernández, Maria, López-Granados, Eduardo, Colobran, Roger, Rivière, Jacques G., Soler-Palacín, Pere, Pujol, Aurora, Esteller, Manel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Burgos (UBU)
Repositorio:Repositorio Institucional de la Universidad de Burgos (RIUBU)
OAI Identifier:oai:riubu.ubu.es:10259/10037
Acceso en línea:http://hdl.handle.net/10259/10037
Access Level:acceso abierto
Palabra clave:Multisystem inflammatory syndrome in children
COVID-19
Kawasaki disease
Epigenetics
DNA methylation
Medicina
Medicine
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spelling Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C): A multicenter, retrospective studyDavalos, VeronicaGarcía-Prieto, Carlos A.Ferrer, GerardoAguilera-Albesa, SergioValencia Ramos, JuanRodríguez-Palmero, AgustíRuiz, MontserratPlanas-Serra, LauraJordan, IolandaAlegría, IosuneFlores-Pérez, PatriciaCantarín, VerónicaFumadó, VictoriaViadero, Maria TeresaRodrigo, CarlosMéndez-Hernández, MariaLópez-Granados, EduardoColobran, RogerRivière, Jacques G.Soler-Palacín, PerePujol, AuroraEsteller, ManelMultisystem inflammatory syndrome in childrenCOVID-19Kawasaki diseaseEpigeneticsDNA methylationMedicinaMedicineMost children and adolescents infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain asymptomatic or develop a mild coronavirus disease 2019 (COVID-19) that usually does not require medical intervention. However, a small proportion of pediatric patients develop a severe clinical condition, multisystem inflammatory syndrome in children (MIS-C). The involvement of epigenetics in the control of the immune response and viral activity prompted us to carry out an epigenomic study to uncover target loci regulated by DNA methylation that could be altered upon the appearance of MIS-C.Unstoppable campaign of Josep Carreras Leukaemia Foundation, Fundacio La Marat o de TV3, Cellex Foundation and CERCA Programme/Generalitat de Catalunya.Elsevier202520252022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10259/10037reponame:Repositorio Institucional de la Universidad de Burgos (RIUBU)instname:Universidad de Burgos (UBU)IngléseClinicalMedicine. 2022, V. 50, p. 101515https://doi.org/10.1016/J.ECLINM.2022.101515Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riubu.ubu.es:10259/100372026-05-28T07:56:11Z
dc.title.none.fl_str_mv Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C): A multicenter, retrospective study
title Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C): A multicenter, retrospective study
spellingShingle Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C): A multicenter, retrospective study
Davalos, Veronica
Multisystem inflammatory syndrome in children
COVID-19
Kawasaki disease
Epigenetics
DNA methylation
Medicina
Medicine
title_short Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C): A multicenter, retrospective study
title_full Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C): A multicenter, retrospective study
title_fullStr Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C): A multicenter, retrospective study
title_full_unstemmed Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C): A multicenter, retrospective study
title_sort Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C): A multicenter, retrospective study
dc.creator.none.fl_str_mv Davalos, Veronica
García-Prieto, Carlos A.
Ferrer, Gerardo
Aguilera-Albesa, Sergio
Valencia Ramos, Juan
Rodríguez-Palmero, Agustí
Ruiz, Montserrat
Planas-Serra, Laura
Jordan, Iolanda
Alegría, Iosune
Flores-Pérez, Patricia
Cantarín, Verónica
Fumadó, Victoria
Viadero, Maria Teresa
Rodrigo, Carlos
Méndez-Hernández, Maria
López-Granados, Eduardo
Colobran, Roger
Rivière, Jacques G.
Soler-Palacín, Pere
Pujol, Aurora
Esteller, Manel
author Davalos, Veronica
author_facet Davalos, Veronica
García-Prieto, Carlos A.
Ferrer, Gerardo
Aguilera-Albesa, Sergio
Valencia Ramos, Juan
Rodríguez-Palmero, Agustí
Ruiz, Montserrat
Planas-Serra, Laura
Jordan, Iolanda
Alegría, Iosune
Flores-Pérez, Patricia
Cantarín, Verónica
Fumadó, Victoria
Viadero, Maria Teresa
Rodrigo, Carlos
Méndez-Hernández, Maria
López-Granados, Eduardo
Colobran, Roger
Rivière, Jacques G.
Soler-Palacín, Pere
Pujol, Aurora
Esteller, Manel
author_role author
author2 García-Prieto, Carlos A.
Ferrer, Gerardo
Aguilera-Albesa, Sergio
Valencia Ramos, Juan
Rodríguez-Palmero, Agustí
Ruiz, Montserrat
Planas-Serra, Laura
Jordan, Iolanda
Alegría, Iosune
Flores-Pérez, Patricia
Cantarín, Verónica
Fumadó, Victoria
Viadero, Maria Teresa
Rodrigo, Carlos
Méndez-Hernández, Maria
López-Granados, Eduardo
Colobran, Roger
Rivière, Jacques G.
Soler-Palacín, Pere
Pujol, Aurora
Esteller, Manel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Multisystem inflammatory syndrome in children
COVID-19
Kawasaki disease
Epigenetics
DNA methylation
Medicina
Medicine
topic Multisystem inflammatory syndrome in children
COVID-19
Kawasaki disease
Epigenetics
DNA methylation
Medicina
Medicine
description Most children and adolescents infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain asymptomatic or develop a mild coronavirus disease 2019 (COVID-19) that usually does not require medical intervention. However, a small proportion of pediatric patients develop a severe clinical condition, multisystem inflammatory syndrome in children (MIS-C). The involvement of epigenetics in the control of the immune response and viral activity prompted us to carry out an epigenomic study to uncover target loci regulated by DNA methylation that could be altered upon the appearance of MIS-C.
publishDate 2022
dc.date.none.fl_str_mv 2022
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10259/10037
url http://hdl.handle.net/10259/10037
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv eClinicalMedicine. 2022, V. 50, p. 101515
https://doi.org/10.1016/J.ECLINM.2022.101515
dc.rights.none.fl_str_mv Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Institucional de la Universidad de Burgos (RIUBU)
instname:Universidad de Burgos (UBU)
instname_str Universidad de Burgos (UBU)
reponame_str Repositorio Institucional de la Universidad de Burgos (RIUBU)
collection Repositorio Institucional de la Universidad de Burgos (RIUBU)
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869425415479623680
score 15,812429

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