Maternal obesity and gestational diabetes are associated with DNA methylation alterations in the offspring throughout the first year of life

ESH 2022 Annual Meeting: June 17-20, Athens (Greece).

Detalles Bibliográficos
Autores: Alba-Linares, Juan J., Fernández-Pérez, Raúl, Ponce-Zanon, Francisco, García-Carbonell, Nuria, Gómez-Zafra, Rafael, Fraga, Mario F., Lurbe, Empar
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/306799
Acceso en línea:http://hdl.handle.net/10261/306799
Access Level:acceso abierto
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dc.title.none.fl_str_mv Maternal obesity and gestational diabetes are associated with DNA methylation alterations in the offspring throughout the first year of life
title Maternal obesity and gestational diabetes are associated with DNA methylation alterations in the offspring throughout the first year of life
spellingShingle Maternal obesity and gestational diabetes are associated with DNA methylation alterations in the offspring throughout the first year of life
Alba-Linares, Juan J.
title_short Maternal obesity and gestational diabetes are associated with DNA methylation alterations in the offspring throughout the first year of life
title_full Maternal obesity and gestational diabetes are associated with DNA methylation alterations in the offspring throughout the first year of life
title_fullStr Maternal obesity and gestational diabetes are associated with DNA methylation alterations in the offspring throughout the first year of life
title_full_unstemmed Maternal obesity and gestational diabetes are associated with DNA methylation alterations in the offspring throughout the first year of life
title_sort Maternal obesity and gestational diabetes are associated with DNA methylation alterations in the offspring throughout the first year of life
dc.creator.none.fl_str_mv Alba-Linares, Juan J.
Fernández-Pérez, Raúl
Ponce-Zanon, Francisco
García-Carbonell, Nuria
Gómez-Zafra, Rafael
Fraga, Mario F.
Lurbe, Empar
author Alba-Linares, Juan J.
author_facet Alba-Linares, Juan J.
Fernández-Pérez, Raúl
Ponce-Zanon, Francisco
García-Carbonell, Nuria
Gómez-Zafra, Rafael
Fraga, Mario F.
Lurbe, Empar
author_role author
author2 Fernández-Pérez, Raúl
Ponce-Zanon, Francisco
García-Carbonell, Nuria
Gómez-Zafra, Rafael
Fraga, Mario F.
Lurbe, Empar
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Asociación Española Contra el Cáncer
Principado de Asturias
European Commission
Instituto de Salud Carlos III
Fundación General CSIC
Ministerio de Ciencia e Innovación (España)
Obra Social Cajastur
Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description ESH 2022 Annual Meeting: June 17-20, Athens (Greece).
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/306799
url http://hdl.handle.net/10261/306799
dc.language.none.fl_str_mv Inglés
Inglés
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info:eu-repo/grantAgreement/AEI//IJC2018-36825-I
http://dx.doi.org/10.1097/01.hjh.0000835704.94772.0b
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
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spelling Maternal obesity and gestational diabetes are associated with DNA methylation alterations in the offspring throughout the first year of lifeAlba-Linares, Juan J.Fernández-Pérez, RaúlPonce-Zanon, FranciscoGarcía-Carbonell, NuriaGómez-Zafra, RafaelFraga, Mario F.Lurbe, EmparESH 2022 Annual Meeting: June 17-20, Athens (Greece).[Objective]: Obesity is a chronic metabolic disease of increasing prevalence and health importance in modern societies, which represents an added risk for the development of multiple pathologies. Moreover, epidemiological studies have shown how maternal obesity or gestational diabetes during pregnancy constitutes an important risk factor related to the appearance of cardiovascular and metabolic diseases in the offspring. Furthermore, this period of life is especially sensitive to extrinsic and intrinsic influence, so epigenetic remodelling may help explain the molecular mechanisms that underlie epidemiological findings. The main objective of this work was to determine the DNA methylation landscape of children born to mothers with obesity and gestational diabetes across their first year of life.[Design and method]: We have characterized the methylome of blood samples from a paediatric cohort of 39 subjects consisting of children born to mothers who suffered from obesity or obesity with gestational diabetes during pregnancy and healthy controls. We performed longitudinal measurements throughout the first year of life (0, 6 and 12 months; total N = 92) using Illumina Infinium MethylationEPIC BeadChip arrays to profile more than 770,000 CpG sites. The design allowed us to carry out both cross-sectional and longitudinal analyses in order to derive DNA methylation alterations associated with developmental and pathological-related epigenomics.[Results]: We have identified abundant DNA methylation alterations during child development from birth to 6 months and, to a lesser extent, until 12 months of age. At the same time, using cross-sectional analyses, we have identified DNA methylation biomarkers that discriminate children born to mothers who suffered from obesity or obesity with gestational diabetes during pregnancy compared to their healthy counterparts. Moreover, our longitudinal design allowed us to determine that these alterations are at least maintained during the first year of life. In addition, gene enrichment analyses revealed that these DNA methylation alterations are associated with regions and genes related to feeding behaviour, appetite, metabolism and cell signalling.[Conclusions]: Our results support the existence of an intrauterine-mediated maternal obesity effect with an impact on the childhood methylome and possible functional implications.This work was supported by: the Spanish Association Against Cancer (grant number PROYE18061FERN to M.F.F.), the Asturias Government (PCTI) cofounding 2018-2022/FEDER (grant number IDI/2018/146 to M.F.F.), the Fundación General CSIC (grant number 0348_CIE_6_E to M.F.F.), the Institute of Health Carlos III (Plan Nacional de I+D+I) cofounding FEDER (grant numbers PI18/01527 and PI21/01067 to M.F.F. and A.F.F.; grant numbers PI17/01517 and PI20/00269 to E.L.), and the Spanish Ministry of Science and Innovation (grant number SGL2021-03-039/40 to M.F.F.) cofounding NextGenerationEU. J.R.T. is supported by a Juan de la Cierva fellowship from the Spanish Ministry of Science and Innovation (grant number IJC2018-36825-I). J.J.A.L. is supported by the Spanish Association Against Cancer (grant number PRDAS21642ALBA). R.F.P. and D.B.R. are supported by the Severo Ochoa program (grant numbers BP17-114 and BP20-186). We also acknowledge support from the Institute of Oncology of Asturias (IUOPA, supported by Obra Social Cajastur Liberbank, Spain), the Health Research Institute of Asturias (ISPA-FINBA), the Health Research Institute INCLIVA and the Biomedical Research Networking Center on Rare Diseases (CIBERER-ISCIII).Peer reviewedLippincott Williams & WilkinsAsociación Española Contra el CáncerPrincipado de AsturiasEuropean CommissionInstituto de Salud Carlos IIIFundación General CSICMinisterio de Ciencia e Innovación (España)Obra Social CajasturAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2023202320222023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttp://hdl.handle.net/10261/306799reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésInglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI//IJC2018-36825-Ihttp://dx.doi.org/10.1097/01.hjh.0000835704.94772.0bSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3067992026-05-22T06:33:51Z
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