Engineering alginate-based injectable hydrogels combined with bioactive polymers for targeted plasma-derived oxidative stress delivery in osteosarcoma therapy
Reactive Oxygen and Nitrogen Species (RONS) in biological systems display hormetic effects, capable of either promoting cell regenerative effects or inducing cell death. Recently, hydrogels have emerged as a promising delivery platform for RONS generated from Cold Atmospheric Plasmas (CAP), known as...
| Autores: | , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/408685 |
| Acceso en línea: | https://hdl.handle.net/2117/408685 https://dx.doi.org/10.1016/j.ijbiomac.2023.128841 |
| Access Level: | acceso abierto |
| Palabra clave: | Colloids in medicine Tissue engineering Col·loides en medicina Enginyeria de teixits Àrees temàtiques de la UPC::Enginyeria biomèdica |
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Engineering alginate-based injectable hydrogels combined with bioactive polymers for targeted plasma-derived oxidative stress delivery in osteosarcoma therapyEspona Noguera, Albert|||0000-0002-3681-030XTampieri, Francesco|||0000-0003-1474-867XCanal Barnils, Cristina|||0000-0002-3039-7462Colloids in medicineTissue engineeringCol·loides en medicinaEnginyeria de teixitsÀrees temàtiques de la UPC::Enginyeria biomèdicaReactive Oxygen and Nitrogen Species (RONS) in biological systems display hormetic effects, capable of either promoting cell regenerative effects or inducing cell death. Recently, hydrogels have emerged as a promising delivery platform for RONS generated from Cold Atmospheric Plasmas (CAP), known as Plasma-Treated Hydrogels (PTH). PTH have been proposed as an alternative therapy to conventional cancer treatments, offering reduced side effects through the controlled and localized delivery of plasma-derived RONS. In this work, we have developed alginate-based PTH with dual therapeutic action provided by plasma-derived RONS acting as selective anticancer agents for osteosarcoma treatment, and biomolecules (hyaluronic acid and gelatin) to promote stem cell-mediated bone regeneration. For this purpose, we designed a novel manufacturing process to maximize the load of plasma-derived RONS within the PTH. Then, we assessed the PTH bioactivity on osteosarcoma MG-63 cells, and human mesenchymal stem cells (hMSCs). The results showed that the PTH composed of 0.25 % alginate +1 % hyaluronic acid is the most promising formulation in osteosarcoma treatment, showing a dual-action bioactivity as a selective cytotoxic anticancer agent, and as promoter of the proliferation and osteogenic differentiation of hMSCs. These findings provide strong evidence of the significant potential of PTH in the oncological field.Peer ReviewedObjectius de Desenvolupament Sostenible::3 - Salut i BenestarElsevier20242024-02-0120242024-05-28journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/408685https://dx.doi.org/10.1016/j.ijbiomac.2023.128841reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/4086852026-05-27T15:37:01Z |
| dc.title.none.fl_str_mv |
Engineering alginate-based injectable hydrogels combined with bioactive polymers for targeted plasma-derived oxidative stress delivery in osteosarcoma therapy |
| title |
Engineering alginate-based injectable hydrogels combined with bioactive polymers for targeted plasma-derived oxidative stress delivery in osteosarcoma therapy |
| spellingShingle |
Engineering alginate-based injectable hydrogels combined with bioactive polymers for targeted plasma-derived oxidative stress delivery in osteosarcoma therapy Espona Noguera, Albert|||0000-0002-3681-030X Colloids in medicine Tissue engineering Col·loides en medicina Enginyeria de teixits Àrees temàtiques de la UPC::Enginyeria biomèdica |
| title_short |
Engineering alginate-based injectable hydrogels combined with bioactive polymers for targeted plasma-derived oxidative stress delivery in osteosarcoma therapy |
| title_full |
Engineering alginate-based injectable hydrogels combined with bioactive polymers for targeted plasma-derived oxidative stress delivery in osteosarcoma therapy |
| title_fullStr |
Engineering alginate-based injectable hydrogels combined with bioactive polymers for targeted plasma-derived oxidative stress delivery in osteosarcoma therapy |
| title_full_unstemmed |
Engineering alginate-based injectable hydrogels combined with bioactive polymers for targeted plasma-derived oxidative stress delivery in osteosarcoma therapy |
| title_sort |
Engineering alginate-based injectable hydrogels combined with bioactive polymers for targeted plasma-derived oxidative stress delivery in osteosarcoma therapy |
| dc.creator.none.fl_str_mv |
Espona Noguera, Albert|||0000-0002-3681-030X Tampieri, Francesco|||0000-0003-1474-867X Canal Barnils, Cristina|||0000-0002-3039-7462 |
| author |
Espona Noguera, Albert|||0000-0002-3681-030X |
| author_facet |
Espona Noguera, Albert|||0000-0002-3681-030X Tampieri, Francesco|||0000-0003-1474-867X Canal Barnils, Cristina|||0000-0002-3039-7462 |
| author_role |
author |
| author2 |
Tampieri, Francesco|||0000-0003-1474-867X Canal Barnils, Cristina|||0000-0002-3039-7462 |
| author2_role |
author author |
| dc.subject.none.fl_str_mv |
Colloids in medicine Tissue engineering Col·loides en medicina Enginyeria de teixits Àrees temàtiques de la UPC::Enginyeria biomèdica |
| topic |
Colloids in medicine Tissue engineering Col·loides en medicina Enginyeria de teixits Àrees temàtiques de la UPC::Enginyeria biomèdica |
| description |
Reactive Oxygen and Nitrogen Species (RONS) in biological systems display hormetic effects, capable of either promoting cell regenerative effects or inducing cell death. Recently, hydrogels have emerged as a promising delivery platform for RONS generated from Cold Atmospheric Plasmas (CAP), known as Plasma-Treated Hydrogels (PTH). PTH have been proposed as an alternative therapy to conventional cancer treatments, offering reduced side effects through the controlled and localized delivery of plasma-derived RONS. In this work, we have developed alginate-based PTH with dual therapeutic action provided by plasma-derived RONS acting as selective anticancer agents for osteosarcoma treatment, and biomolecules (hyaluronic acid and gelatin) to promote stem cell-mediated bone regeneration. For this purpose, we designed a novel manufacturing process to maximize the load of plasma-derived RONS within the PTH. Then, we assessed the PTH bioactivity on osteosarcoma MG-63 cells, and human mesenchymal stem cells (hMSCs). The results showed that the PTH composed of 0.25 % alginate +1 % hyaluronic acid is the most promising formulation in osteosarcoma treatment, showing a dual-action bioactivity as a selective cytotoxic anticancer agent, and as promoter of the proliferation and osteogenic differentiation of hMSCs. These findings provide strong evidence of the significant potential of PTH in the oncological field. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024-02-01 2024 2024-05-28 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 AM http://purl.org/coar/version/c_ab4af688f83e57aa |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2117/408685 https://dx.doi.org/10.1016/j.ijbiomac.2023.128841 |
| url |
https://hdl.handle.net/2117/408685 https://dx.doi.org/10.1016/j.ijbiomac.2023.128841 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:UPCommons. Portal del coneixement obert de la UPC instname:Universitat Politècnica de Catalunya (UPC) |
| instname_str |
Universitat Politècnica de Catalunya (UPC) |
| reponame_str |
UPCommons. Portal del coneixement obert de la UPC |
| collection |
UPCommons. Portal del coneixement obert de la UPC |
| repository.name.fl_str_mv |
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| repository.mail.fl_str_mv |
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1869425413671878657 |
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15,811543 |