Septal gabaergic inputs to CA1 govern contextual memory retrieval

The CA1 output region of the hippocampus plays an essential role in the retrieval of episodic memories. γ-Aminobutyric acid-releasing (GABAergic) long-range projections from the medial septum (MS) densely innervate the hippocampus, but whether septal inputs regulate memory expression remains elusive...

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Detalles Bibliográficos
Autores: Sans-Dublanc, Arnau, Razzauti, Adrià, Desikan, Srinidhi, Pascual Sánchez, Marta, Monyer, Hannah, Sindreu Balet, Carlos
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/178138
Acceso en línea:https://hdl.handle.net/2445/178138
Access Level:acceso abierto
Palabra clave:Hipocamp (Cervell)
Memòria
Hippocampus (Brain)
Memory
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spelling Septal gabaergic inputs to CA1 govern contextual memory retrievalSans-Dublanc, ArnauRazzauti, AdriàDesikan, SrinidhiPascual Sánchez, MartaMonyer, HannahSindreu Balet, CarlosHipocamp (Cervell)MemòriaHippocampus (Brain)MemoryThe CA1 output region of the hippocampus plays an essential role in the retrieval of episodic memories. γ-Aminobutyric acid-releasing (GABAergic) long-range projections from the medial septum (MS) densely innervate the hippocampus, but whether septal inputs regulate memory expression remains elusive. We found that the MS to CA1 connection is recruited during recall of a contextual fear memory. Chemogenetic silencing of CA1-projecting MS neurons or septal GABAergic terminals within CA1 blocked memory retrieval. Photostimulation of septal GABAergic terminals in CA1 selectively inhibited interneurons. Abrogating septal GABAergic cells during retrieval disinhibited parvalbumin-rich (PV+) cells in CA1. Direct activation of CA1 PV+ cells impaired memory and prevented the induction of extracellular signal-regulated kinase/mitogen-activated kinase signaling in postsynaptic pyramidal neurons. Opposing disinhibition of hippocampal PV+ cells reversibly restored memory. Our data indicate that suppression of feed-forward inhibition onto CA1 by septal GABAergic neurons is an important mechanism in gating contextual fear behavior.American Association for the Advancement of Science2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/178138Articles publicats en revistes (Fonaments Clínics)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1126/sciadv.aba5003Science Advances, 2020, vol. 6, num. 44https://doi.org/10.1126/sciadv.aba5003cc-by-nc (c) Sans Dublanc1, Arnau et al., 2020https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1781382026-05-27T06:46:51Z
dc.title.none.fl_str_mv Septal gabaergic inputs to CA1 govern contextual memory retrieval
title Septal gabaergic inputs to CA1 govern contextual memory retrieval
spellingShingle Septal gabaergic inputs to CA1 govern contextual memory retrieval
Sans-Dublanc, Arnau
Hipocamp (Cervell)
Memòria
Hippocampus (Brain)
Memory
title_short Septal gabaergic inputs to CA1 govern contextual memory retrieval
title_full Septal gabaergic inputs to CA1 govern contextual memory retrieval
title_fullStr Septal gabaergic inputs to CA1 govern contextual memory retrieval
title_full_unstemmed Septal gabaergic inputs to CA1 govern contextual memory retrieval
title_sort Septal gabaergic inputs to CA1 govern contextual memory retrieval
dc.creator.none.fl_str_mv Sans-Dublanc, Arnau
Razzauti, Adrià
Desikan, Srinidhi
Pascual Sánchez, Marta
Monyer, Hannah
Sindreu Balet, Carlos
author Sans-Dublanc, Arnau
author_facet Sans-Dublanc, Arnau
Razzauti, Adrià
Desikan, Srinidhi
Pascual Sánchez, Marta
Monyer, Hannah
Sindreu Balet, Carlos
author_role author
author2 Razzauti, Adrià
Desikan, Srinidhi
Pascual Sánchez, Marta
Monyer, Hannah
Sindreu Balet, Carlos
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Hipocamp (Cervell)
Memòria
Hippocampus (Brain)
Memory
topic Hipocamp (Cervell)
Memòria
Hippocampus (Brain)
Memory
description The CA1 output region of the hippocampus plays an essential role in the retrieval of episodic memories. γ-Aminobutyric acid-releasing (GABAergic) long-range projections from the medial septum (MS) densely innervate the hippocampus, but whether septal inputs regulate memory expression remains elusive. We found that the MS to CA1 connection is recruited during recall of a contextual fear memory. Chemogenetic silencing of CA1-projecting MS neurons or septal GABAergic terminals within CA1 blocked memory retrieval. Photostimulation of septal GABAergic terminals in CA1 selectively inhibited interneurons. Abrogating septal GABAergic cells during retrieval disinhibited parvalbumin-rich (PV+) cells in CA1. Direct activation of CA1 PV+ cells impaired memory and prevented the induction of extracellular signal-regulated kinase/mitogen-activated kinase signaling in postsynaptic pyramidal neurons. Opposing disinhibition of hippocampal PV+ cells reversibly restored memory. Our data indicate that suppression of feed-forward inhibition onto CA1 by septal GABAergic neurons is an important mechanism in gating contextual fear behavior.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/178138
url https://hdl.handle.net/2445/178138
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1126/sciadv.aba5003
Science Advances, 2020, vol. 6, num. 44
https://doi.org/10.1126/sciadv.aba5003
dc.rights.none.fl_str_mv cc-by-nc (c) Sans Dublanc1, Arnau et al., 2020
https://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Sans Dublanc1, Arnau et al., 2020
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Association for the Advancement of Science
publisher.none.fl_str_mv American Association for the Advancement of Science
dc.source.none.fl_str_mv Articles publicats en revistes (Fonaments Clínics)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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