Trabeculated Myocardium in Hypertrophic Cardiomyopathy: Clinical Consequences

Aims: Hypertrophic cardiomyopathy (HCM) is often accompanied by increased trabeculated myocardium (TM)-which clinical relevance is unknown. We aim to measure the left ventricular (LV) mass and proportion of trabeculation in an HCM population and to analyze its clinical implication. Methods and Resul...

Descripción completa

Detalles Bibliográficos
Autores: Casanova, José David, González Carrillo, Josefá, Martín Jiménez, Jesús, Cuenca Muñoz, Javier, Muñoz Esparza, Carmen, Siguero Álvarez, Marcos, Escribá, Rubén, Burillo Milla, Esther, Pompa, José Luis de la, Raya Chamorro, Ángel, Gimeno, Juan Ramón, Sabater Molina, María, Bernabé García, Gregorio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/174119
Acceso en línea:https://hdl.handle.net/2445/174119
Access Level:acceso abierto
Palabra clave:Malalties del cor
Miocardiopaties
Heart diseases
Myocardiopathies
id ES_fc5030fceab5e1d02ba4ed0dca8a4d06
oai_identifier_str oai:recercat.cat:2445/174119
network_acronym_str ES
network_name_str España
repository_id_str
spelling Trabeculated Myocardium in Hypertrophic Cardiomyopathy: Clinical ConsequencesCasanova, José DavidGonzález Carrillo, JosefáMartín Jiménez, JesúsCuenca Muñoz, JavierMuñoz Esparza, CarmenSiguero Álvarez, MarcosEscribá, RubénBurillo Milla, EstherPompa, José Luis de laRaya Chamorro, ÁngelGimeno, Juan RamónSabater Molina, MaríaBernabé García, GregorioMalalties del corMiocardiopatiesHeart diseasesMyocardiopathiesAims: Hypertrophic cardiomyopathy (HCM) is often accompanied by increased trabeculated myocardium (TM)-which clinical relevance is unknown. We aim to measure the left ventricular (LV) mass and proportion of trabeculation in an HCM population and to analyze its clinical implication. Methods and Results: We evaluated 211 patients with HCM (mean age 47.8 +/- 16.3 years, 73.0% males) with cardiac magnetic resonance (CMR) studies. LV trabecular and compacted mass were measured using dedicated software for automatic delineation of borders. Mean compacted myocardium (CM) was 160.0 +/- 62.0 g and trabecular myocardium (TM) 55.5 +/- 18.7 g. The percentage of trabeculated myocardium (TM%) was 26.7% +/- 6.4%. Females had significantly increased TM% compared to males (29.7 +/- 7.2 vs. 25.6 +/- 5.8, p < 0.0001). Patients with LVEF < 50% had significantly higher values of TM% (30.2% +/- 6.0% vs. 26.6% +/- 6.4%, p = 0.02). Multivariable analysis showed that female gender and neutral pattern of hypertrophy were directly associated with TM%, while dynamic obstruction, maximal wall thickness and LVEF% were inversely associated with TM%. There was no association between TM% with arterial hypertension, physical activity, or symptoms. Atrial fibrillation and severity of hypertrophy were the only variables associated with cardiovascular death. Multivariable analysis failed to demonstrate any correlation between TM% and arrhythmias. Conclusions: Approximately 25% of myocardium appears non-compacted and can automatically be measured in HCM series. Proportion of non-compacted myocardium is increased in female, non-obstructives, and in those with lower contractility. The amount of trabeculation might help to identify HCM patients prone to systolic heart failure.Mdpi2021202120202021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/174119Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/jcm9103171Journal of Clinical Medicine, 2020, Vol. 9 (10), num. 3171https://doi.org/10.3390/jcm9103171cc by (c) Casanova, José David et al., 2020http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1741192026-05-29T05:05:01Z
dc.title.none.fl_str_mv Trabeculated Myocardium in Hypertrophic Cardiomyopathy: Clinical Consequences
title Trabeculated Myocardium in Hypertrophic Cardiomyopathy: Clinical Consequences
spellingShingle Trabeculated Myocardium in Hypertrophic Cardiomyopathy: Clinical Consequences
Casanova, José David
Malalties del cor
Miocardiopaties
Heart diseases
Myocardiopathies
title_short Trabeculated Myocardium in Hypertrophic Cardiomyopathy: Clinical Consequences
title_full Trabeculated Myocardium in Hypertrophic Cardiomyopathy: Clinical Consequences
title_fullStr Trabeculated Myocardium in Hypertrophic Cardiomyopathy: Clinical Consequences
title_full_unstemmed Trabeculated Myocardium in Hypertrophic Cardiomyopathy: Clinical Consequences
title_sort Trabeculated Myocardium in Hypertrophic Cardiomyopathy: Clinical Consequences
dc.creator.none.fl_str_mv Casanova, José David
González Carrillo, Josefá
Martín Jiménez, Jesús
Cuenca Muñoz, Javier
Muñoz Esparza, Carmen
Siguero Álvarez, Marcos
Escribá, Rubén
Burillo Milla, Esther
Pompa, José Luis de la
Raya Chamorro, Ángel
Gimeno, Juan Ramón
Sabater Molina, María
Bernabé García, Gregorio
author Casanova, José David
author_facet Casanova, José David
González Carrillo, Josefá
Martín Jiménez, Jesús
Cuenca Muñoz, Javier
Muñoz Esparza, Carmen
Siguero Álvarez, Marcos
Escribá, Rubén
Burillo Milla, Esther
Pompa, José Luis de la
Raya Chamorro, Ángel
Gimeno, Juan Ramón
Sabater Molina, María
Bernabé García, Gregorio
author_role author
author2 González Carrillo, Josefá
Martín Jiménez, Jesús
Cuenca Muñoz, Javier
Muñoz Esparza, Carmen
Siguero Álvarez, Marcos
Escribá, Rubén
Burillo Milla, Esther
Pompa, José Luis de la
Raya Chamorro, Ángel
Gimeno, Juan Ramón
Sabater Molina, María
Bernabé García, Gregorio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalties del cor
Miocardiopaties
Heart diseases
Myocardiopathies
topic Malalties del cor
Miocardiopaties
Heart diseases
Myocardiopathies
description Aims: Hypertrophic cardiomyopathy (HCM) is often accompanied by increased trabeculated myocardium (TM)-which clinical relevance is unknown. We aim to measure the left ventricular (LV) mass and proportion of trabeculation in an HCM population and to analyze its clinical implication. Methods and Results: We evaluated 211 patients with HCM (mean age 47.8 +/- 16.3 years, 73.0% males) with cardiac magnetic resonance (CMR) studies. LV trabecular and compacted mass were measured using dedicated software for automatic delineation of borders. Mean compacted myocardium (CM) was 160.0 +/- 62.0 g and trabecular myocardium (TM) 55.5 +/- 18.7 g. The percentage of trabeculated myocardium (TM%) was 26.7% +/- 6.4%. Females had significantly increased TM% compared to males (29.7 +/- 7.2 vs. 25.6 +/- 5.8, p < 0.0001). Patients with LVEF < 50% had significantly higher values of TM% (30.2% +/- 6.0% vs. 26.6% +/- 6.4%, p = 0.02). Multivariable analysis showed that female gender and neutral pattern of hypertrophy were directly associated with TM%, while dynamic obstruction, maximal wall thickness and LVEF% were inversely associated with TM%. There was no association between TM% with arterial hypertension, physical activity, or symptoms. Atrial fibrillation and severity of hypertrophy were the only variables associated with cardiovascular death. Multivariable analysis failed to demonstrate any correlation between TM% and arrhythmias. Conclusions: Approximately 25% of myocardium appears non-compacted and can automatically be measured in HCM series. Proportion of non-compacted myocardium is increased in female, non-obstructives, and in those with lower contractility. The amount of trabeculation might help to identify HCM patients prone to systolic heart failure.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/174119
url https://hdl.handle.net/2445/174119
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/jcm9103171
Journal of Clinical Medicine, 2020, Vol. 9 (10), num. 3171
https://doi.org/10.3390/jcm9103171
dc.rights.none.fl_str_mv cc by (c) Casanova, José David et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Casanova, José David et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Mdpi
publisher.none.fl_str_mv Mdpi
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869425410754740224
score 15.812429

Similares en LA Referencia