Cadmium-induced neurotoxic effects on rat basal forebrain cholinergic system through thyroid hormones disruption

Cadmium (Cd) single and repeated exposure produces cognitive dysfunctions. Basal forebrain cholinergic neu rons (BFCN) regulate cognitive functions. BFCN loss or cholinergic neurotransmission dysfunction leads to cognitive disabilities. Thyroid hormones (THs) maintain BFCN viability and functions, a...

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Autores: Sola Vendrell, Emma, Moyano-Cires Ivanoff, Paula Viviana, Flores A, García Lobo, Jimena, García Sánchez, José Manuel, Frejo Moya, María Teresa, Anadón Baselga, María José, Pelayo Alarcón, Adela, Fernández Fernández, María De La Cabeza, Del Pino J, Pino Sans, Javier Del
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/115572
Acceso en línea:https://hdl.handle.net/20.500.14352/115572
Access Level:acceso abierto
Palabra clave:615.9
Cadmium
Basal forebrain cholinergic neurons
AChE
ChAT
T3
M1R and M3R
Toxicología (Medicina)
3214 Toxicología
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oai_identifier_str oai:docta.ucm.es:20.500.14352/115572
network_acronym_str ES
network_name_str España
repository_id_str
spelling Cadmium-induced neurotoxic effects on rat basal forebrain cholinergic system through thyroid hormones disruptionSola Vendrell, EmmaMoyano-Cires Ivanoff, Paula VivianaFlores AGarcía Lobo, JimenaGarcía Sánchez, José ManuelFrejo Moya, María TeresaAnadón Baselga, María JoséPelayo Alarcón, AdelaFernández Fernández, María De La CabezaDel Pino JPino Sans, Javier Del615.9CadmiumBasal forebrain cholinergic neuronsAChEChATT3M1R and M3RToxicología (Medicina)3214 ToxicologíaCadmium (Cd) single and repeated exposure produces cognitive dysfunctions. Basal forebrain cholinergic neu rons (BFCN) regulate cognitive functions. BFCN loss or cholinergic neurotransmission dysfunction leads to cognitive disabilities. Thyroid hormones (THs) maintain BFCN viability and functions, and Cd disrupts their levels. However, Cd-induced BFCN damages and THs disruption involvement was not studied. To research this we treated male Wistar rats intraperitoneally with Cd once (1 mg/kg) or repetitively for 28 days (0.1 mg/kg) with/without triiodothyronine (T3, 40 µg/kg/day). Cd increased thyroid-stimulating-hormone (TSH) and decreased T3 and tetraiodothyronine (T4). Cd altered cholinergic transmission and induced a more pronounced neurodegeneration on BFCN, mediated partially by THs reduction. Additionally, Cd antagonized muscarinic 1 receptor (M1R), overexpressed acetylcholinesterase S variant (AChE-S), downregulated AChE-R, M2R, M3R and M4R, and reduced AChE and choline acetyltransferase activities through THs disruption. These results may assist to discover cadmium mechanisms that induce cognitive disabilities, revealing a new possible therapeutic tool.ElsevierUniversidad Complutense de Madrid20212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/115572reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1155722026-06-02T12:44:21Z
dc.title.none.fl_str_mv Cadmium-induced neurotoxic effects on rat basal forebrain cholinergic system through thyroid hormones disruption
title Cadmium-induced neurotoxic effects on rat basal forebrain cholinergic system through thyroid hormones disruption
spellingShingle Cadmium-induced neurotoxic effects on rat basal forebrain cholinergic system through thyroid hormones disruption
Sola Vendrell, Emma
615.9
Cadmium
Basal forebrain cholinergic neurons
AChE
ChAT
T3
M1R and M3R
Toxicología (Medicina)
3214 Toxicología
title_short Cadmium-induced neurotoxic effects on rat basal forebrain cholinergic system through thyroid hormones disruption
title_full Cadmium-induced neurotoxic effects on rat basal forebrain cholinergic system through thyroid hormones disruption
title_fullStr Cadmium-induced neurotoxic effects on rat basal forebrain cholinergic system through thyroid hormones disruption
title_full_unstemmed Cadmium-induced neurotoxic effects on rat basal forebrain cholinergic system through thyroid hormones disruption
title_sort Cadmium-induced neurotoxic effects on rat basal forebrain cholinergic system through thyroid hormones disruption
dc.creator.none.fl_str_mv Sola Vendrell, Emma
Moyano-Cires Ivanoff, Paula Viviana
Flores A
García Lobo, Jimena
García Sánchez, José Manuel
Frejo Moya, María Teresa
Anadón Baselga, María José
Pelayo Alarcón, Adela
Fernández Fernández, María De La Cabeza
Del Pino J
Pino Sans, Javier Del
author Sola Vendrell, Emma
author_facet Sola Vendrell, Emma
Moyano-Cires Ivanoff, Paula Viviana
Flores A
García Lobo, Jimena
García Sánchez, José Manuel
Frejo Moya, María Teresa
Anadón Baselga, María José
Pelayo Alarcón, Adela
Fernández Fernández, María De La Cabeza
Del Pino J
Pino Sans, Javier Del
author_role author
author2 Moyano-Cires Ivanoff, Paula Viviana
Flores A
García Lobo, Jimena
García Sánchez, José Manuel
Frejo Moya, María Teresa
Anadón Baselga, María José
Pelayo Alarcón, Adela
Fernández Fernández, María De La Cabeza
Del Pino J
Pino Sans, Javier Del
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 615.9
Cadmium
Basal forebrain cholinergic neurons
AChE
ChAT
T3
M1R and M3R
Toxicología (Medicina)
3214 Toxicología
topic 615.9
Cadmium
Basal forebrain cholinergic neurons
AChE
ChAT
T3
M1R and M3R
Toxicología (Medicina)
3214 Toxicología
description Cadmium (Cd) single and repeated exposure produces cognitive dysfunctions. Basal forebrain cholinergic neu rons (BFCN) regulate cognitive functions. BFCN loss or cholinergic neurotransmission dysfunction leads to cognitive disabilities. Thyroid hormones (THs) maintain BFCN viability and functions, and Cd disrupts their levels. However, Cd-induced BFCN damages and THs disruption involvement was not studied. To research this we treated male Wistar rats intraperitoneally with Cd once (1 mg/kg) or repetitively for 28 days (0.1 mg/kg) with/without triiodothyronine (T3, 40 µg/kg/day). Cd increased thyroid-stimulating-hormone (TSH) and decreased T3 and tetraiodothyronine (T4). Cd altered cholinergic transmission and induced a more pronounced neurodegeneration on BFCN, mediated partially by THs reduction. Additionally, Cd antagonized muscarinic 1 receptor (M1R), overexpressed acetylcholinesterase S variant (AChE-S), downregulated AChE-R, M2R, M3R and M4R, and reduced AChE and choline acetyltransferase activities through THs disruption. These results may assist to discover cadmium mechanisms that induce cognitive disabilities, revealing a new possible therapeutic tool.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/115572
url https://hdl.handle.net/20.500.14352/115572
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869425409625423872
score 15,812455

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