Growth rate controls mRNA turnover in steady and non-steady states

Gene expression has been investigated in relation with growth rate in the yeast Saccharomyces cerevisiae, following different experimental strategies. The expression of some specific gene functional categories increases or decreases with growth rate. Our recently published results have unveiled that...

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Detalles Bibliográficos
Autores: García Martínez, José, Troulé, K., Chávez de Diego, Sebastián, Pérez Ortín, José E.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/76086
Acceso en línea:https://hdl.handle.net/11441/76086
https://doi.org/10.1080/15476286.2016.1236171
Access Level:acceso abierto
Palabra clave:Gene expression
Saccharomyces cerevisiae
growth rate
mRNA stability
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spelling Growth rate controls mRNA turnover in steady and non-steady statesGarcía Martínez, JoséTroulé, K.Chávez de Diego, SebastiánPérez Ortín, José E.Gene expressionSaccharomyces cerevisiaegrowth ratemRNA stabilityGene expression has been investigated in relation with growth rate in the yeast Saccharomyces cerevisiae, following different experimental strategies. The expression of some specific gene functional categories increases or decreases with growth rate. Our recently published results have unveiled that these changes in mRNA concentration with growth depend on the relative alteration of mRNA synthesis and decay, and that, in addition to this gene-specific transcriptomic signature of growth, global mRNA turnover increases with growth rate. We discuss here these results in relation with other previous and concurrent publications, and we add new evidence which indicates that growth rate controls mRNA turnover even under non-steady-state conditions.Ministerio de Economía, Industria y Competitividad BFU2013-48643-C3-3-PMinisterio de Economía, Industria y Competitividad BFU2013-48643-C3-1-PUnión Europea Fondos FEDERGeneralitat Valenciana PROMETEO II 2015/006Junta de Andalucía P12-BIO1938MOTaylor & FrancisGenéticaBIO271: Expresión Génica en Eucariontes2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/76086https://doi.org/10.1080/15476286.2016.1236171reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésRNA Biology, 13 (12), 1175-1181.info:eu-repo/semantics/openAccessoai:idus.us.es:11441/760862026-06-17T12:51:07Z
dc.title.none.fl_str_mv Growth rate controls mRNA turnover in steady and non-steady states
title Growth rate controls mRNA turnover in steady and non-steady states
spellingShingle Growth rate controls mRNA turnover in steady and non-steady states
García Martínez, José
Gene expression
Saccharomyces cerevisiae
growth rate
mRNA stability
title_short Growth rate controls mRNA turnover in steady and non-steady states
title_full Growth rate controls mRNA turnover in steady and non-steady states
title_fullStr Growth rate controls mRNA turnover in steady and non-steady states
title_full_unstemmed Growth rate controls mRNA turnover in steady and non-steady states
title_sort Growth rate controls mRNA turnover in steady and non-steady states
dc.creator.none.fl_str_mv García Martínez, José
Troulé, K.
Chávez de Diego, Sebastián
Pérez Ortín, José E.
author García Martínez, José
author_facet García Martínez, José
Troulé, K.
Chávez de Diego, Sebastián
Pérez Ortín, José E.
author_role author
author2 Troulé, K.
Chávez de Diego, Sebastián
Pérez Ortín, José E.
author2_role author
author
author
dc.contributor.none.fl_str_mv Genética
BIO271: Expresión Génica en Eucariontes
dc.subject.none.fl_str_mv Gene expression
Saccharomyces cerevisiae
growth rate
mRNA stability
topic Gene expression
Saccharomyces cerevisiae
growth rate
mRNA stability
description Gene expression has been investigated in relation with growth rate in the yeast Saccharomyces cerevisiae, following different experimental strategies. The expression of some specific gene functional categories increases or decreases with growth rate. Our recently published results have unveiled that these changes in mRNA concentration with growth depend on the relative alteration of mRNA synthesis and decay, and that, in addition to this gene-specific transcriptomic signature of growth, global mRNA turnover increases with growth rate. We discuss here these results in relation with other previous and concurrent publications, and we add new evidence which indicates that growth rate controls mRNA turnover even under non-steady-state conditions.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/76086
https://doi.org/10.1080/15476286.2016.1236171
url https://hdl.handle.net/11441/76086
https://doi.org/10.1080/15476286.2016.1236171
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv RNA Biology, 13 (12), 1175-1181.
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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