Changes in the microbiological diagnosis and epidemiology of cutaneous leishmaniasis in real-time PCR era: A six-year experience in a referral center in Barcelona
Leishmania; Reacción en cadena de la polimerasa; España
| Autores: | , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repositorio: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/7551 |
| Acceso en línea: | https://hdl.handle.net/11351/7551 |
| Access Level: | acceso abierto |
| Palabra clave: | Leishmaniosi - Diagnòstic Leishmaniosi - Epidemiologia Reacció en cadena de la polimerasa DISEASES::Parasitic Diseases::Protozoan Infections::Euglenozoa Infections::Leishmaniasis::Leishmaniasis, Cutaneous Other subheadings::Other subheadings::/diagnosis ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Genetic Techniques::Nucleic Acid Amplification Techniques::Polymerase Chain Reaction::Real-Time Polymerase Chain Reaction ENFERMEDADES::enfermedades parasitarias::infecciones por protozoos::infecciones por Euglenozoa::leishmaniosis::leishmaniasis cutánea Otros calificadores::Otros calificadores::/diagnóstico TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::técnicas genéticas::técnicas de amplificación de ácidos nucleicos::reacción en cadena de la polimerasa::reacción en cadena de la polimerasa en tiempo real |
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| dc.title.none.fl_str_mv |
Changes in the microbiological diagnosis and epidemiology of cutaneous leishmaniasis in real-time PCR era: A six-year experience in a referral center in Barcelona |
| title |
Changes in the microbiological diagnosis and epidemiology of cutaneous leishmaniasis in real-time PCR era: A six-year experience in a referral center in Barcelona |
| spellingShingle |
Changes in the microbiological diagnosis and epidemiology of cutaneous leishmaniasis in real-time PCR era: A six-year experience in a referral center in Barcelona Silgado Gimenez, Aroa Leishmaniosi - Diagnòstic Leishmaniosi - Epidemiologia Reacció en cadena de la polimerasa DISEASES::Parasitic Diseases::Protozoan Infections::Euglenozoa Infections::Leishmaniasis::Leishmaniasis, Cutaneous Other subheadings::Other subheadings::/diagnosis ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Genetic Techniques::Nucleic Acid Amplification Techniques::Polymerase Chain Reaction::Real-Time Polymerase Chain Reaction ENFERMEDADES::enfermedades parasitarias::infecciones por protozoos::infecciones por Euglenozoa::leishmaniosis::leishmaniasis cutánea Otros calificadores::Otros calificadores::/diagnóstico TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::técnicas genéticas::técnicas de amplificación de ácidos nucleicos::reacción en cadena de la polimerasa::reacción en cadena de la polimerasa en tiempo real |
| title_short |
Changes in the microbiological diagnosis and epidemiology of cutaneous leishmaniasis in real-time PCR era: A six-year experience in a referral center in Barcelona |
| title_full |
Changes in the microbiological diagnosis and epidemiology of cutaneous leishmaniasis in real-time PCR era: A six-year experience in a referral center in Barcelona |
| title_fullStr |
Changes in the microbiological diagnosis and epidemiology of cutaneous leishmaniasis in real-time PCR era: A six-year experience in a referral center in Barcelona |
| title_full_unstemmed |
Changes in the microbiological diagnosis and epidemiology of cutaneous leishmaniasis in real-time PCR era: A six-year experience in a referral center in Barcelona |
| title_sort |
Changes in the microbiological diagnosis and epidemiology of cutaneous leishmaniasis in real-time PCR era: A six-year experience in a referral center in Barcelona |
| dc.creator.none.fl_str_mv |
Silgado Gimenez, Aroa Armas Cruz, Mayuli Goterris Bonet, Lidia Ubals Cazorla, Maria Aparicio Español, Gloria Serre Delcor, Nuria Ferrer Fábrega, Berta García-Patos Briones, Vicente Pumarola Suñé, Tomàs Sulleiro Igual, Elena Molina Romero, Israel Temprana Salvador, Jordi Sánchez Montalvá, Adrián |
| author |
Silgado Gimenez, Aroa |
| author_facet |
Silgado Gimenez, Aroa Armas Cruz, Mayuli Goterris Bonet, Lidia Ubals Cazorla, Maria Aparicio Español, Gloria Serre Delcor, Nuria Ferrer Fábrega, Berta García-Patos Briones, Vicente Pumarola Suñé, Tomàs Sulleiro Igual, Elena Molina Romero, Israel Temprana Salvador, Jordi Sánchez Montalvá, Adrián |
| author_role |
author |
| author2 |
Armas Cruz, Mayuli Goterris Bonet, Lidia Ubals Cazorla, Maria Aparicio Español, Gloria Serre Delcor, Nuria Ferrer Fábrega, Berta García-Patos Briones, Vicente Pumarola Suñé, Tomàs Sulleiro Igual, Elena Molina Romero, Israel Temprana Salvador, Jordi Sánchez Montalvá, Adrián |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Silgado A, Armas M, Goterris L, Pumarola T, Sulleiro E] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. PROSICS Barcelona, Barcelona, Spain. [Sánchez-Montalvá A, Serre-Delcor N, Molina I] Servei de Malalties Infeccioses, Drassanes-Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. PROSICS Barcelona, Barcelona, Spain. [Ubals M, Aparicio G, García-Patos V] Servei de Dermatologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Temprana-Salvador J, Ferrer B] Servei de Patologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Leishmaniosi - Diagnòstic Leishmaniosi - Epidemiologia Reacció en cadena de la polimerasa DISEASES::Parasitic Diseases::Protozoan Infections::Euglenozoa Infections::Leishmaniasis::Leishmaniasis, Cutaneous Other subheadings::Other subheadings::/diagnosis ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Genetic Techniques::Nucleic Acid Amplification Techniques::Polymerase Chain Reaction::Real-Time Polymerase Chain Reaction ENFERMEDADES::enfermedades parasitarias::infecciones por protozoos::infecciones por Euglenozoa::leishmaniosis::leishmaniasis cutánea Otros calificadores::Otros calificadores::/diagnóstico TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::técnicas genéticas::técnicas de amplificación de ácidos nucleicos::reacción en cadena de la polimerasa::reacción en cadena de la polimerasa en tiempo real |
| topic |
Leishmaniosi - Diagnòstic Leishmaniosi - Epidemiologia Reacció en cadena de la polimerasa DISEASES::Parasitic Diseases::Protozoan Infections::Euglenozoa Infections::Leishmaniasis::Leishmaniasis, Cutaneous Other subheadings::Other subheadings::/diagnosis ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Genetic Techniques::Nucleic Acid Amplification Techniques::Polymerase Chain Reaction::Real-Time Polymerase Chain Reaction ENFERMEDADES::enfermedades parasitarias::infecciones por protozoos::infecciones por Euglenozoa::leishmaniosis::leishmaniasis cutánea Otros calificadores::Otros calificadores::/diagnóstico TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::técnicas genéticas::técnicas de amplificación de ácidos nucleicos::reacción en cadena de la polimerasa::reacción en cadena de la polimerasa en tiempo real |
| description |
Leishmania; Reacción en cadena de la polimerasa; España |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2022 2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/7551 |
| url |
https://hdl.handle.net/11351/7551 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
PLOS Neglected Tropical Diseases;15(11) https://doi.org/10.1371/journal.pntd.0009884 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Public Library of Science |
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Public Library of Science |
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Scientia reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut instname:Departament de Salut de la Generalitat de Catalunya (DS) |
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Departament de Salut de la Generalitat de Catalunya (DS) |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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1869425396118716416 |
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Changes in the microbiological diagnosis and epidemiology of cutaneous leishmaniasis in real-time PCR era: A six-year experience in a referral center in BarcelonaSilgado Gimenez, AroaArmas Cruz, MayuliGoterris Bonet, LidiaUbals Cazorla, MariaAparicio Español, GloriaSerre Delcor, NuriaFerrer Fábrega, BertaGarcía-Patos Briones, VicentePumarola Suñé, TomàsSulleiro Igual, ElenaMolina Romero, IsraelTemprana Salvador, JordiSánchez Montalvá, AdriánLeishmaniosi - DiagnòsticLeishmaniosi - EpidemiologiaReacció en cadena de la polimerasaDISEASES::Parasitic Diseases::Protozoan Infections::Euglenozoa Infections::Leishmaniasis::Leishmaniasis, CutaneousOther subheadings::Other subheadings::/diagnosisANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Genetic Techniques::Nucleic Acid Amplification Techniques::Polymerase Chain Reaction::Real-Time Polymerase Chain ReactionENFERMEDADES::enfermedades parasitarias::infecciones por protozoos::infecciones por Euglenozoa::leishmaniosis::leishmaniasis cutáneaOtros calificadores::Otros calificadores::/diagnósticoTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::técnicas genéticas::técnicas de amplificación de ácidos nucleicos::reacción en cadena de la polimerasa::reacción en cadena de la polimerasa en tiempo realLeishmania; Reacción en cadena de la polimerasa; EspañaLeishmania; Polymerase chain reaction; SpainLeishmania; Reacció en cadena de la polimerasa; EspanyaBackground Leishmaniasis is a neglected disease caused by different species of the protozoa Leishmania spp. Cutaneous lesions are the most common clinical manifestation. This disease is prevalent in tropical and subtropical areas, including the Mediterranean basin. In Spain, Leishmania (L.) infantum is the only endemic species, but imported cases are often diagnosed. Different classical parasitological methods can be performed for cutaneous leishmaniasis (CL) diagnosis; but currently molecular techniques serve as a relevant tool for the detection and characterization of Leishmania parasites. We aimed to evaluate clinical and epidemiological characteristics of CL diagnosed patients by real-time PCR in a tertiary hospital over a six-year period. Methodology/Principal findings Clinical, epidemiological and microbiological data were retrospectively collected and analyzed. In our study, CL was confirmed in 59 (31.4%) out of 188 patients by real-time PCR, showing an increase over recent years: 11 cases of CL between 2014 and 2016 and 48 between 2017 and 2019. Real-time PCR was performed on skin swabs and/or biopsies samples, with a positivity of 38.5% and 26.5%, respectively. Results were 100% concordant when biopsy and skin swab were performed simultaneously. L. (L.) infantum was the most frequent species detected (50%), followed by L. (L.) major (45%) and Viannia subgenus (5%), which were detected only in imported cases. L. (L.) major was almost entirely detected in travelers/migrants from Morocco. Multiple and atypical skin lesions were more common in imported cases than in autochthonous cases (44.4% vs. 21.8%). Conclusions/Significance An increase in both autochthonous and imported CL cases has been observed in past years in our hospital. Molecular techniques assist in improving CL diagnosis and characterization of the Leishmania species, mainly in imported cases.The author(s) received no specific funding for this work.Public Library of ScienceInstitut Català de la Salut[Silgado A, Armas M, Goterris L, Pumarola T, Sulleiro E] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. PROSICS Barcelona, Barcelona, Spain. [Sánchez-Montalvá A, Serre-Delcor N, Molina I] Servei de Malalties Infeccioses, Drassanes-Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. PROSICS Barcelona, Barcelona, Spain. [Ubals M, Aparicio G, García-Patos V] Servei de Dermatologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Temprana-Salvador J, Ferrer B] Servei de Patologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, SpainVall d'Hebron Barcelona Hospital Campus202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7551Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésPLOS Neglected Tropical Diseases;15(11)https://doi.org/10.1371/journal.pntd.0009884Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/75512026-06-12T09:38:37Z |
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15,198674 |