Analysis of porcine MUC4 gene as a candidate gene for prolificacy QTL on SSC13 in an Iberian × Meishan F2 population

[Background]: Reproductive traits, such as prolificacy, are of great interest to the pig industry. Better understanding of their genetic architecture should help to increase the efficiency of pig productivity through the implementation of marker assisted selection (MAS) programmes.

Detalles Bibliográficos
Autores: Balcells, Ingrid, Castelló, Anna, Mercadé, Anna, Noguera, José L., Fernández-Rodríguez, Amanda, Sánchez, Armand, Tomàs, Anna
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2011
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/247907
Acceso en línea:http://hdl.handle.net/10261/247907
Access Level:acceso abierto
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spelling Analysis of porcine MUC4 gene as a candidate gene for prolificacy QTL on SSC13 in an Iberian × Meishan F2 populationBalcells, IngridCastelló, AnnaMercadé, AnnaNoguera, José L.Fernández-Rodríguez, AmandaSánchez, ArmandTomàs, Anna[Background]: Reproductive traits, such as prolificacy, are of great interest to the pig industry. Better understanding of their genetic architecture should help to increase the efficiency of pig productivity through the implementation of marker assisted selection (MAS) programmes.[Results]: The Mucin 4 (MUC4) gene has been evaluated as a candidate gene for a prolificacy QTL described in an Iberian × Meishan (Ib × Me) F2 intercross. For association analyses, two previously described SNPs (DQ124298:g.243A>G and DQ124298:g.344A>G) were genotyped in 347 pigs from the Ib × Me population. QTL for the number of piglets born alive (NBA) and for the total number of piglets born (TNB) were confirmed on SSC13 at positions 44 cM and 51 cM, respectively. The MUC4 gene was successfully located within the confidence intervals of both QTL. Only DQ124298:g.344A>G MUC4 polymorphism was significantly associated with both NBA and TNB (P-value < 0.05) with favourable effects coming from the Meishan origin. MUC4 expression level was determined in F2 sows displaying extreme phenotypes for the number of embryos (NE) at 30-32 days of gestation. Differences in the uterine expression of MUC4 were found between high (NE ≥ 13) and low (NE ≤ 11) prolificacy sows. Overall, MUC4 expression in high prolificacy sows was almost two-fold increased compared with low prolificacy sows.[Conclusions]: Our data suggest that MUC4 could play an important role in the establishment of an optimal uterine environment that would increase embryonic survival during pig gestation.This research was funded in part by Project AGL2004-08368-C03 and by the Consolider-Ingenio 2010 Programme (CSD2007-00036), both from the Spanish Ministry of Science and Innovation. IB is the recipient of a PIF PhD fellowship from Universitat Autònoma de Barcelona.Peer reviewedBioMed CentralMinisterio de Ciencia e Innovación (España)Universidad Autónoma de BarcelonaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212011info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/247907reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésDepartamento de Mejora Genética Animalhttps://doi.org/10.1186/1471-2156-12-93Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2479072026-05-22T06:33:51Z
dc.title.none.fl_str_mv Analysis of porcine MUC4 gene as a candidate gene for prolificacy QTL on SSC13 in an Iberian × Meishan F2 population
title Analysis of porcine MUC4 gene as a candidate gene for prolificacy QTL on SSC13 in an Iberian × Meishan F2 population
spellingShingle Analysis of porcine MUC4 gene as a candidate gene for prolificacy QTL on SSC13 in an Iberian × Meishan F2 population
Balcells, Ingrid
title_short Analysis of porcine MUC4 gene as a candidate gene for prolificacy QTL on SSC13 in an Iberian × Meishan F2 population
title_full Analysis of porcine MUC4 gene as a candidate gene for prolificacy QTL on SSC13 in an Iberian × Meishan F2 population
title_fullStr Analysis of porcine MUC4 gene as a candidate gene for prolificacy QTL on SSC13 in an Iberian × Meishan F2 population
title_full_unstemmed Analysis of porcine MUC4 gene as a candidate gene for prolificacy QTL on SSC13 in an Iberian × Meishan F2 population
title_sort Analysis of porcine MUC4 gene as a candidate gene for prolificacy QTL on SSC13 in an Iberian × Meishan F2 population
dc.creator.none.fl_str_mv Balcells, Ingrid
Castelló, Anna
Mercadé, Anna
Noguera, José L.
Fernández-Rodríguez, Amanda
Sánchez, Armand
Tomàs, Anna
author Balcells, Ingrid
author_facet Balcells, Ingrid
Castelló, Anna
Mercadé, Anna
Noguera, José L.
Fernández-Rodríguez, Amanda
Sánchez, Armand
Tomàs, Anna
author_role author
author2 Castelló, Anna
Mercadé, Anna
Noguera, José L.
Fernández-Rodríguez, Amanda
Sánchez, Armand
Tomàs, Anna
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Universidad Autónoma de Barcelona
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description [Background]: Reproductive traits, such as prolificacy, are of great interest to the pig industry. Better understanding of their genetic architecture should help to increase the efficiency of pig productivity through the implementation of marker assisted selection (MAS) programmes.
publishDate 2011
dc.date.none.fl_str_mv 2011
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/247907
url http://hdl.handle.net/10261/247907
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Departamento de Mejora Genética Animal
https://doi.org/10.1186/1471-2156-12-93
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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