Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial
On behalf of the MoMoPa-EC Research Group Anna Planas-Ballvé, Pau Pastor, Ignacio Alvarez, Mª Isabel Morales Casado, Sara Lucas del Pozo, Anna Prats, Álvaro Sánchez-Ferro, Antonio Méndez Guerrero, Carlos Leiva Santana, Laura Muñoz-Delgado, Daniel Macías-García, Silvia Jesús, Astrid Adarmes-Gómez, An...
| Autores: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/402609 |
| Acceso en línea: | http://hdl.handle.net/10261/402609 https://api.elsevier.com/content/abstract/scopus_id/105014633564 |
| Access Level: | acceso abierto |
| Palabra clave: | Neurological disorders Neurology Parkinson's disease |
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| dc.title.none.fl_str_mv |
Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial |
| title |
Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial |
| spellingShingle |
Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial Rodríguez-Molinero, Alejandro Neurological disorders Neurology Parkinson's disease |
| title_short |
Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial |
| title_full |
Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial |
| title_fullStr |
Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial |
| title_full_unstemmed |
Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial |
| title_sort |
Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial |
| dc.creator.none.fl_str_mv |
Rodríguez-Molinero, Alejandro Pérez-López, Carlos Caballol, Nuria Buongiorno, Maria Teresa Ávila-Rivera, María A. López-Ariztegui, Nuria López-Manzanares, Lydia Hernández-Vara, Jorge Bayes-Rusiñol, Àngels Gironell Carreró, Alexandre Álvarez-Sauco, María Franquet Gomez, Elisabet Pérez-Martínez, David A. Escalante Arroyo, Sonia Martí Martínez, Silvia Mir, Pablo Salom Juan, José María Martinez-Castrillo, Juan Carlos Tebé, Cristian On behalf of the MoMoPa-EC Research Group |
| author |
Rodríguez-Molinero, Alejandro |
| author_facet |
Rodríguez-Molinero, Alejandro Pérez-López, Carlos Caballol, Nuria Buongiorno, Maria Teresa Ávila-Rivera, María A. López-Ariztegui, Nuria López-Manzanares, Lydia Hernández-Vara, Jorge Bayes-Rusiñol, Àngels Gironell Carreró, Alexandre Álvarez-Sauco, María Franquet Gomez, Elisabet Pérez-Martínez, David A. Escalante Arroyo, Sonia Martí Martínez, Silvia Mir, Pablo Salom Juan, José María Martinez-Castrillo, Juan Carlos Tebé, Cristian On behalf of the MoMoPa-EC Research Group |
| author_role |
author |
| author2 |
Pérez-López, Carlos Caballol, Nuria Buongiorno, Maria Teresa Ávila-Rivera, María A. López-Ariztegui, Nuria López-Manzanares, Lydia Hernández-Vara, Jorge Bayes-Rusiñol, Àngels Gironell Carreró, Alexandre Álvarez-Sauco, María Franquet Gomez, Elisabet Pérez-Martínez, David A. Escalante Arroyo, Sonia Martí Martínez, Silvia Mir, Pablo Salom Juan, José María Martinez-Castrillo, Juan Carlos Tebé, Cristian On behalf of the MoMoPa-EC Research Group |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Salud Carlos III European Commission Pérez-López, Carlos [0000-0003-4544-5735] Mir, Pablo [0000-0003-1656-302X] Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Neurological disorders Neurology Parkinson's disease |
| topic |
Neurological disorders Neurology Parkinson's disease |
| description |
On behalf of the MoMoPa-EC Research Group Anna Planas-Ballvé, Pau Pastor, Ignacio Alvarez, Mª Isabel Morales Casado, Sara Lucas del Pozo, Anna Prats, Álvaro Sánchez-Ferro, Antonio Méndez Guerrero, Carlos Leiva Santana, Laura Muñoz-Delgado, Daniel Macías-García, Silvia Jesús, Astrid Adarmes-Gómez, Antonio Salvador Aliaga, Gema Sánchez, Esther Cubo, Lourdes Ispierto González, Ramiro Álvarez-Ramo, Dolores Vilas Rolan, Antonio Koukoulis Fernández, Mª Gema Alonso Losada, Jon Infante, María Sierra Peña, Isabel González Aramburu, Mª Victoria Sánchez Peláez, Marina Mata Álvarez-Santullano, Carmen Borrúe Fernández, Mª Concepción Jimeno Montero, Lydia Vela Desojo, Berta Solano Vila, Anna Cots Foraster, Daniel López Domínguez, Esteban Peña Llamas, Pilar Sánchez Alonso, Elisa Gamo Gonzalez, Sabela Novo Ponte, Alfredo López López, Mª José Gómez Heredia, Francisco Pérez Errazquin, Mª Pilar Solís Pérez, Esther Blanco Vicente, Rafael García Ruiz, Ana Rita Santos Pinto, Marta Recio-Bermejo, Ernest Balaguer, Antonio Hernández Vidal, Rocío García-Ramos, Eva López Valdés, Rubén Alonso Redondo, Jessica González Ardura, Teresa Muñoz Ruiz, Lucía Flores García, Javier Ruiz Martínez, Ana Vinagre Aragón, Ioana Croitoru, Esther Catena Ruiz, Victor Puente, Irene Navalpotro Gómez & Antonio Miñarro |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 2025 2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10261/402609 https://api.elsevier.com/content/abstract/scopus_id/105014633564 |
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http://hdl.handle.net/10261/402609 https://api.elsevier.com/content/abstract/scopus_id/105014633564 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1038/s41531-025-00977-2 https://doi.org/10.1038/s41531-025-00977-2 Sí |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Nature Publishing Group |
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Nature Publishing Group |
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reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
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Consejo Superior de Investigaciones Científicas (CSIC) |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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1869425380537925632 |
| spelling |
Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trialRodríguez-Molinero, AlejandroPérez-López, CarlosCaballol, NuriaBuongiorno, Maria TeresaÁvila-Rivera, María A.López-Ariztegui, NuriaLópez-Manzanares, LydiaHernández-Vara, JorgeBayes-Rusiñol, ÀngelsGironell Carreró, AlexandreÁlvarez-Sauco, MaríaFranquet Gomez, ElisabetPérez-Martínez, David A.Escalante Arroyo, SoniaMartí Martínez, SilviaMir, PabloSalom Juan, José MaríaMartinez-Castrillo, Juan CarlosTebé, CristianOn behalf of the MoMoPa-EC Research GroupNeurological disordersNeurologyParkinson's diseaseOn behalf of the MoMoPa-EC Research Group Anna Planas-Ballvé, Pau Pastor, Ignacio Alvarez, Mª Isabel Morales Casado, Sara Lucas del Pozo, Anna Prats, Álvaro Sánchez-Ferro, Antonio Méndez Guerrero, Carlos Leiva Santana, Laura Muñoz-Delgado, Daniel Macías-García, Silvia Jesús, Astrid Adarmes-Gómez, Antonio Salvador Aliaga, Gema Sánchez, Esther Cubo, Lourdes Ispierto González, Ramiro Álvarez-Ramo, Dolores Vilas Rolan, Antonio Koukoulis Fernández, Mª Gema Alonso Losada, Jon Infante, María Sierra Peña, Isabel González Aramburu, Mª Victoria Sánchez Peláez, Marina Mata Álvarez-Santullano, Carmen Borrúe Fernández, Mª Concepción Jimeno Montero, Lydia Vela Desojo, Berta Solano Vila, Anna Cots Foraster, Daniel López Domínguez, Esteban Peña Llamas, Pilar Sánchez Alonso, Elisa Gamo Gonzalez, Sabela Novo Ponte, Alfredo López López, Mª José Gómez Heredia, Francisco Pérez Errazquin, Mª Pilar Solís Pérez, Esther Blanco Vicente, Rafael García Ruiz, Ana Rita Santos Pinto, Marta Recio-Bermejo, Ernest Balaguer, Antonio Hernández Vidal, Rocío García-Ramos, Eva López Valdés, Rubén Alonso Redondo, Jessica González Ardura, Teresa Muñoz Ruiz, Lucía Flores García, Javier Ruiz Martínez, Ana Vinagre Aragón, Ioana Croitoru, Esther Catena Ruiz, Victor Puente, Irene Navalpotro Gómez & Antonio MiñarroParkinson’s disease (PD) is characterized by motor fluctuations, with alternating periods of good (“ON”) and poor (“OFF”) motor function. Monitoring these fluctuations is crucial for optimizing treatment, yet traditional methods rely on subjective patient reports. This multicenter, single-blind, cluster-randomized trial evaluated the effectiveness of three monitoring approaches in real-world clinical practice. Neurologists from 35 centers were randomized into three groups: one using clinical visit data alone, another incorporating Hauser diary entries, and a third integrating Parkinson’s Holter (STAT-ON®) reports. A total of 156 patients were recruited. Changes in ‘OFF time’ from baseline to 26 weeks were minimal and non-significant across groups. Secondary outcomes, including ‘ON time,’ dyskinesia, and quality-of-life scores, showed no significant differences. These findings suggest that the choice of motor fluctuation monitoring method may not significantly impact clinical outcomes, underscoring the need for a broader understanding of how these monitoring tools are integrated and utilized in real-world settings. Trial registration: NCT04176302 (November 21, 2019 - ClinicalTrials.gov).This work is supported by the Instituto de Salud Carlos III [DTS17/00195], the "A way to make Europe" European Fund for Regional Development, and AbbVie S.L.U.The authors would like to thank the i2e3 Procomms (Barcelona, Spain) team and especially, Jesús Loureiro, Ph.D., and Sara Cervantes, Ph.D., for providing medical writing support during the manuscript preparation.Peer reviewedNature Publishing GroupInstituto de Salud Carlos IIIEuropean CommissionPérez-López, Carlos [0000-0003-4544-5735]Mir, Pablo [0000-0003-1656-302X]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/402609https://api.elsevier.com/content/abstract/scopus_id/105014633564reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1038/s41531-025-00977-2https://doi.org/10.1038/s41531-025-00977-2Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4026092026-05-22T06:33:51Z |
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15,812455 |