Immunomodulatory effects of bacteriocinogenic and non-bacteriocinogenic Lactococcus cremoris of aquatic origin on rainbow trout (Oncorhynchus mykiss, Walbaum)

Contente, Diogo; Díaz-Rosales, Patricia; Feito, Javier; Díaz-Formoso, Lara; Docando, Félix; Simón, Rocío; Borrero, Juan; Hernández, Pablo E.; Poeta, Patrícia; Muñoz-Atienza, E.; Cintas, Luis M.; Tafalla, Carolina

Immunomodulatory effects of bacteriocinogenic and non-bacteriocinogenic Lactococcus cremoris of aquatic origin on rainbow trout (Oncorhynchus mykiss, Walbaum)

11 Pág.

Detalles Bibliográficos
Autores:	Contente, Diogo, Díaz-Rosales, Patricia, Feito, Javier, Díaz-Formoso, Lara, Docando, Félix, Simón, Rocío, Borrero, Juan, Hernández, Pablo E., Poeta, Patrícia, Muñoz-Atienza, E., Cintas, Luis M., Tafalla, Carolina
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2023
País:	España
Institución:	Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:	DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:	oai:digital.csic.es:10261/329775
Acceso en línea:	http://hdl.handle.net/10261/329775 https://api.elsevier.com/content/abstract/scopus_id/85158041513
Access Level:	acceso abierto
Palabra clave:	Bacteriocins Fish Immunomodulation Lactic acid bacteria Nisin Probiotics

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dc.title.none.fl_str_mv	Immunomodulatory effects of bacteriocinogenic and non-bacteriocinogenic Lactococcus cremoris of aquatic origin on rainbow trout (Oncorhynchus mykiss, Walbaum)
title	Immunomodulatory effects of bacteriocinogenic and non-bacteriocinogenic Lactococcus cremoris of aquatic origin on rainbow trout (Oncorhynchus mykiss, Walbaum)
spellingShingle	Immunomodulatory effects of bacteriocinogenic and non-bacteriocinogenic Lactococcus cremoris of aquatic origin on rainbow trout (Oncorhynchus mykiss, Walbaum) Contente, Diogo Bacteriocins Fish Immunomodulation Lactic acid bacteria Nisin Probiotics
title_short	Immunomodulatory effects of bacteriocinogenic and non-bacteriocinogenic Lactococcus cremoris of aquatic origin on rainbow trout (Oncorhynchus mykiss, Walbaum)
title_full	Immunomodulatory effects of bacteriocinogenic and non-bacteriocinogenic Lactococcus cremoris of aquatic origin on rainbow trout (Oncorhynchus mykiss, Walbaum)
title_fullStr	Immunomodulatory effects of bacteriocinogenic and non-bacteriocinogenic Lactococcus cremoris of aquatic origin on rainbow trout (Oncorhynchus mykiss, Walbaum)
title_full_unstemmed	Immunomodulatory effects of bacteriocinogenic and non-bacteriocinogenic Lactococcus cremoris of aquatic origin on rainbow trout (Oncorhynchus mykiss, Walbaum)
title_sort	Immunomodulatory effects of bacteriocinogenic and non-bacteriocinogenic Lactococcus cremoris of aquatic origin on rainbow trout (Oncorhynchus mykiss, Walbaum)
dc.creator.none.fl_str_mv	Contente, Diogo Díaz-Rosales, Patricia Feito, Javier Díaz-Formoso, Lara Docando, Félix Simón, Rocío Borrero, Juan Hernández, Pablo E. Poeta, Patrícia Muñoz-Atienza, E. Cintas, Luis M. Tafalla, Carolina
author	Contente, Diogo
author_facet	Contente, Diogo Díaz-Rosales, Patricia Feito, Javier Díaz-Formoso, Lara Docando, Félix Simón, Rocío Borrero, Juan Hernández, Pablo E. Poeta, Patrícia Muñoz-Atienza, E. Cintas, Luis M. Tafalla, Carolina
author_role	author
author2	Díaz-Rosales, Patricia Feito, Javier Díaz-Formoso, Lara Docando, Félix Simón, Rocío Borrero, Juan Hernández, Pablo E. Poeta, Patrícia Muñoz-Atienza, E. Cintas, Luis M. Tafalla, Carolina
author2_role	author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Ministerio de Ciencia e Innovación (España) Agencia Estatal de Investigación (España) Universidad Complutense de Madrid Ministerio de Trabajo y Economía Social (España) European Commission Comunidad de Madrid Contente, Diogo [0000-0002-7513-9432] Díaz-Rosales, Patricia [0000-0001-6965-3702] Díaz-Formoso, Lara [0000-0002-1176-8475] Docando, Félix [0000-0001-8835-9349] Hernández, Pablo E. [0000-0001-6259-8456] Poeta, Patrícia [0000-0003-0925-689X] Muñoz-Atienza, E. [0000-0001-6218-1511] Cintas, Luis M. [0000-0003-4161-0385] Tafalla, Carolina [0000-0002-0860-2976] Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv	Bacteriocins Fish Immunomodulation Lactic acid bacteria Nisin Probiotics
topic	Bacteriocins Fish Immunomodulation Lactic acid bacteria Nisin Probiotics
description	11 Pág.
publishDate	2023
dc.date.none.fl_str_mv	2023 2023 2023
dc.type.none.fl_str_mv	info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10261/329775 https://api.elsevier.com/content/abstract/scopus_id/85158041513
url	http://hdl.handle.net/10261/329775 https://api.elsevier.com/content/abstract/scopus_id/85158041513
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	#PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094907-B-I00 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113268RB-I00 S2018-T1/BIO-10158/Atracción de Talento Investigador Centro de Investigación en Sanidad Animal (CISA) https://doi.org/10.3389/fimmu.2023.1178462 Sí
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Frontiers Media
publisher.none.fl_str_mv	Frontiers Media
dc.source.none.fl_str_mv	reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str	Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str	DIGITAL.CSIC. Repositorio Institucional del CSIC
collection	DIGITAL.CSIC. Repositorio Institucional del CSIC
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spelling	Immunomodulatory effects of bacteriocinogenic and non-bacteriocinogenic Lactococcus cremoris of aquatic origin on rainbow trout (Oncorhynchus mykiss, Walbaum)Contente, DiogoDíaz-Rosales, PatriciaFeito, JavierDíaz-Formoso, LaraDocando, FélixSimón, RocíoBorrero, JuanHernández, Pablo E.Poeta, PatríciaMuñoz-Atienza, E.Cintas, Luis M.Tafalla, CarolinaBacteriocinsFishImmunomodulationLactic acid bacteriaNisinProbiotics11 Pág.Lactic Acid Bacteria (LAB) are a group of bacteria frequently proposed as probiotics in aquaculture, as their administration has shown to confer positive effects on the growth, survival rate to pathogens and immunological status of the fish. In this respect, the production of antimicrobial peptides (referred to as bacteriocins) by LAB is a common trait thoroughly documented, being regarded as a key probiotic antimicrobial strategy. Although some studies have pointed to the direct immunomodulatory effects of these bacteriocins in mammals, this has been largely unexplored in fish. To this aim, in the current study, we have investigated the immunomodulatory effects of bacteriocins, by comparing the effects of a wild type nisin Z-expressing Lactococcus cremoris strain of aquatic origin to those exerted by a non-bacteriocinogenic isogenic mutant and a recombinant nisin Z, garvicin A and Q-producer multi-bacteriocinogenic strain. The transcriptional response elicited by the different strains in the rainbow trout intestinal epithelial cell line (RTgutGC) and in splenic leukocytes showed significant differences. Yet the adherence capacity to RTgutGC was similar for all strains. In splenocyte cultures, we also determined the effects of the different strains on the proliferation and survival of IgM+ B cells. Finally, while the different LAB elicited respiratory burst activity similarly, the bacteriocinogenic strains showed an increased ability to induce the production of nitric oxide (NO). The results obtained reveal a superior capacity of the bacteriocinogenic strains to modulate different immune functions, pointing to a direct immunomodulatory role of the bacteriocins, mainly nisin Z.This work was supported by the Ministerio de Ciencia e Innovación (MICINN, Madrid, Spain) (projects RTI2018-094907-B-I00, and PID2020-113268RB-I00), and the Universidad Complutense de Madrid (UCM) (project FEI16/54). DC was supported by a contract from the project RTI2018-094907-B-I00. JF was supported by a FEI16/54 contract and held a predoctoral contract from UCM. LD-F was supported by a contract from the “Programa Investigo” (Ministerio de Trabajo y Economía Social, Madrid, Spain), funded by the EU (NextGenerationEU). JB was supported by the Atracción de Talento, program of the Comunidad de Madrid, Spain (2018-T1/BIO-10158).Peer reviewedFrontiers MediaMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)Universidad Complutense de MadridMinisterio de Trabajo y Economía Social (España)European CommissionComunidad de MadridContente, Diogo [0000-0002-7513-9432]Díaz-Rosales, Patricia [0000-0001-6965-3702]Díaz-Formoso, Lara [0000-0002-1176-8475]Docando, Félix [0000-0001-8835-9349]Hernández, Pablo E. [0000-0001-6259-8456]Poeta, Patrícia [0000-0003-0925-689X]Muñoz-Atienza, E. [0000-0001-6218-1511]Cintas, Luis M. [0000-0003-4161-0385]Tafalla, Carolina [0000-0002-0860-2976]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/329775https://api.elsevier.com/content/abstract/scopus_id/85158041513reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094907-B-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113268RB-I00S2018-T1/BIO-10158/Atracción de Talento InvestigadorCentro de Investigación en Sanidad Animal (CISA)https://doi.org/10.3389/fimmu.2023.1178462Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3297752026-05-22T06:33:51Z
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Immunomodulatory effects of bacteriocinogenic and non-bacteriocinogenic Lactococcus cremoris of aquatic origin on rainbow trout (Oncorhynchus mykiss, Walbaum)

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