PROFAST: A randomised trial implementing enhanced recovery after surgery for highcomplexity advanced ovarian cancer surgery

Advanced ovarian cancer; Complete cytoreductive surgery; Peritoneal carcinomatosis

Detalles Bibliográficos
Autores: Sanchez Iglesias, Jose Luis, Carbonell-Socias, Melchor, PEREZ BENAVENTE, ASUNCION, MONREAL CLUA, SONIA, Manrique, Susana, García Gorriz, Manel, Segurola Gurrutxaga, Hegoi, Pamies Serrano, Mónica, Gutiérrez-Barceló, Ma Del Pilar, Serrano-Castro, Susana, Balcells-Farré, Ma Teresa, Pérez-Barragán, Carmen, Scaillet-Houberechts, Axelle, Cossio Gil, Yolima, Burgos Peláez, Rosa, Gil-Moreno, Antonio
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/11005
Acceso en línea:https://hdl.handle.net/11351/11005
Access Level:acceso embargado
Palabra clave:Ovaris - Càncer - Cirurgia
Postoperatori
DISEASES::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Ovarian Neoplasms
Other subheadings::Other subheadings::Other subheadings::/surgery
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Cytoreduction Surgical Procedures
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas::neoplasias ováricas
Otros calificadores::Otros calificadores::Otros calificadores::/cirugía
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::procedimientos quirúrgicos citorreductores
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network_name_str España
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dc.title.none.fl_str_mv PROFAST: A randomised trial implementing enhanced recovery after surgery for highcomplexity advanced ovarian cancer surgery
title PROFAST: A randomised trial implementing enhanced recovery after surgery for highcomplexity advanced ovarian cancer surgery
spellingShingle PROFAST: A randomised trial implementing enhanced recovery after surgery for highcomplexity advanced ovarian cancer surgery
Sanchez Iglesias, Jose Luis
Ovaris - Càncer - Cirurgia
Postoperatori
DISEASES::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Ovarian Neoplasms
Other subheadings::Other subheadings::Other subheadings::/surgery
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Cytoreduction Surgical Procedures
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas::neoplasias ováricas
Otros calificadores::Otros calificadores::Otros calificadores::/cirugía
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::procedimientos quirúrgicos citorreductores
title_short PROFAST: A randomised trial implementing enhanced recovery after surgery for highcomplexity advanced ovarian cancer surgery
title_full PROFAST: A randomised trial implementing enhanced recovery after surgery for highcomplexity advanced ovarian cancer surgery
title_fullStr PROFAST: A randomised trial implementing enhanced recovery after surgery for highcomplexity advanced ovarian cancer surgery
title_full_unstemmed PROFAST: A randomised trial implementing enhanced recovery after surgery for highcomplexity advanced ovarian cancer surgery
title_sort PROFAST: A randomised trial implementing enhanced recovery after surgery for highcomplexity advanced ovarian cancer surgery
dc.creator.none.fl_str_mv Sanchez Iglesias, Jose Luis
Carbonell-Socias, Melchor
PEREZ BENAVENTE, ASUNCION
MONREAL CLUA, SONIA
Manrique, Susana
García Gorriz, Manel
Segurola Gurrutxaga, Hegoi
Pamies Serrano, Mónica
Gutiérrez-Barceló, Ma Del Pilar
Serrano-Castro, Susana
Balcells-Farré, Ma Teresa
Pérez-Barragán, Carmen
Scaillet-Houberechts, Axelle
Cossio Gil, Yolima
Burgos Peláez, Rosa
Gil-Moreno, Antonio
author Sanchez Iglesias, Jose Luis
author_facet Sanchez Iglesias, Jose Luis
Carbonell-Socias, Melchor
PEREZ BENAVENTE, ASUNCION
MONREAL CLUA, SONIA
Manrique, Susana
García Gorriz, Manel
Segurola Gurrutxaga, Hegoi
Pamies Serrano, Mónica
Gutiérrez-Barceló, Ma Del Pilar
Serrano-Castro, Susana
Balcells-Farré, Ma Teresa
Pérez-Barragán, Carmen
Scaillet-Houberechts, Axelle
Cossio Gil, Yolima
Burgos Peláez, Rosa
Gil-Moreno, Antonio
author_role author
author2 Carbonell-Socias, Melchor
PEREZ BENAVENTE, ASUNCION
MONREAL CLUA, SONIA
Manrique, Susana
García Gorriz, Manel
Segurola Gurrutxaga, Hegoi
Pamies Serrano, Mónica
Gutiérrez-Barceló, Ma Del Pilar
Serrano-Castro, Susana
Balcells-Farré, Ma Teresa
Pérez-Barragán, Carmen
Scaillet-Houberechts, Axelle
Cossio Gil, Yolima
Burgos Peláez, Rosa
Gil-Moreno, Antonio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Sánchez-Iglesias JL, Carbonell-Socias M, Pérez-Benavente MA, Monreal Clua S] Unitat de Ginecologia Oncològica i Patologia del Tracte Genital, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Manrique-Muñoz S, García Gorriz M] Unitat d’Anestesiologia i Reanimació, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Burgos-Peláez R, Segurola Gurrutxaga H, Pamies Serrano M, Pilar Gutiérrez-Barceló MD] Unitat de Suport Nutricional, Servei d’Endocrinologia i Nutrició, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Serrano-Castro S] Unitat d’Infermeria d’Oncologia Ginecològica i Malalties Mamàries, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Balcells-Farré MT, Pérez-Barragán C, Scaillet-Houberechts A, Cossio-Gil Y] Direcció de Sistemes d’Informació, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Gestió del Sistema d’Atenció Sanitària, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Gil-Moreno A] Unitat de Ginecologia Oncològica i Patologia del Tracte Genital, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBERONC, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Ovaris - Càncer - Cirurgia
Postoperatori
DISEASES::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Ovarian Neoplasms
Other subheadings::Other subheadings::Other subheadings::/surgery
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Cytoreduction Surgical Procedures
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas::neoplasias ováricas
Otros calificadores::Otros calificadores::Otros calificadores::/cirugía
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::procedimientos quirúrgicos citorreductores
topic Ovaris - Càncer - Cirurgia
Postoperatori
DISEASES::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Ovarian Neoplasms
Other subheadings::Other subheadings::Other subheadings::/surgery
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Cytoreduction Surgical Procedures
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas::neoplasias ováricas
Otros calificadores::Otros calificadores::Otros calificadores::/cirugía
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::procedimientos quirúrgicos citorreductores
description Advanced ovarian cancer; Complete cytoreductive surgery; Peritoneal carcinomatosis
publishDate 2020
dc.date.none.fl_str_mv 2020
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/11005
url https://hdl.handle.net/11351/11005
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling PROFAST: A randomised trial implementing enhanced recovery after surgery for highcomplexity advanced ovarian cancer surgerySanchez Iglesias, Jose LuisCarbonell-Socias, MelchorPEREZ BENAVENTE, ASUNCIONMONREAL CLUA, SONIAManrique, SusanaGarcía Gorriz, ManelSegurola Gurrutxaga, HegoiPamies Serrano, MónicaGutiérrez-Barceló, Ma Del PilarSerrano-Castro, SusanaBalcells-Farré, Ma TeresaPérez-Barragán, CarmenScaillet-Houberechts, AxelleCossio Gil, YolimaBurgos Peláez, RosaGil-Moreno, AntonioOvaris - Càncer - CirurgiaPostoperatoriDISEASES::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Ovarian NeoplasmsOther subheadings::Other subheadings::Other subheadings::/surgeryANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Cytoreduction Surgical ProceduresENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas::neoplasias ováricasOtros calificadores::Otros calificadores::Otros calificadores::/cirugíaTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::procedimientos quirúrgicos citorreductoresAdvanced ovarian cancer; Complete cytoreductive surgery; Peritoneal carcinomatosisCáncer de ovario avanzado; Cirugía citorreductora completa; Carcinomatosis peritonealCàncer d'ovari avançat; Cirurgia citoreductora completa; Carcinomatosi peritonealBackground Enhanced recovery after surgery (ERAS) programs include multiple perioperative elements designed to achieve early recovery after surgery and a shorter length of stay (LOS) in hospital. The PROFAST trial aimed to expand the evidence base for implementing ERAS in advanced gynaecologic oncology surgery. Methods This prospective, interventional randomised clinical trial enrolled women undergoing surgery for either suspected or diagnosed advanced ovarian cancer, at a reference hospital in gynaecologic oncology in Barcelona (Spain) and who were treated after either an ERAS protocol or conventional management (CM) protocol. All enrolled women who underwent cytoreductive surgery were included in the primary analysis. The primary outcome was reduction in LOS, and secondary outcomes were incidence and type of intraoperative and postoperative complications, rate of readmission and mortality within a 30-d follow-up period. This trial is registered at ClinicalTrials.gov , number NCT02172638 . Findings From June 2014 to March 2018, 110 women were recruited, of which eleven were excluded. The ERAS group comprised 50 patients, and the CM group, 49 patients. Both groups were comparable with respect to baseline characteristics and complexity of the cytoreductive surgery, with an overall medium/high Aletti surgical complexity score of 7.4. Overall compliance to the ERAS protocol was 92%. As compared with the patients in the CM group, patients in the ERAS group had a decreased median of LOS of two days (7 versus 9 days; p = 0.0099) and a decreased rate of readmission (6% versus 20%, p = 0.0334). No further significant differences were detected with respect to incidence of intraoperative or postoperative complications, severe (Clavien–Dindo grade IIIB–IV) complications, Comprehensive Complication Index, reoperation during primary stay, or mortality. Interpretation Patients with advanced ovarian cancer in the ERAS program had a decreased LOS and decreased rate of readmission as compared with those in CM, with no increased morbidity or mortality. This study provides important evidence for the benefits of ERAS management even for gynaecologic surgeries of medium/high complexity and suggests that ERAS should be a standard practice for cytoreductive surgeries for peritoneal carcinomatosis.Institut Català de la Salut[Sánchez-Iglesias JL, Carbonell-Socias M, Pérez-Benavente MA, Monreal Clua S] Unitat de Ginecologia Oncològica i Patologia del Tracte Genital, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Manrique-Muñoz S, García Gorriz M] Unitat d’Anestesiologia i Reanimació, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Burgos-Peláez R, Segurola Gurrutxaga H, Pamies Serrano M, Pilar Gutiérrez-Barceló MD] Unitat de Suport Nutricional, Servei d’Endocrinologia i Nutrició, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Serrano-Castro S] Unitat d’Infermeria d’Oncologia Ginecològica i Malalties Mamàries, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Balcells-Farré MT, Pérez-Barragán C, Scaillet-Houberechts A, Cossio-Gil Y] Direcció de Sistemes d’Informació, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Gestió del Sistema d’Atenció Sanitària, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Gil-Moreno A] Unitat de Ginecologia Oncològica i Patologia del Tracte Genital, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBERONC, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202420242020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/11351/11005Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/embargoedAccessoai:recercat.cat:11351/110052026-05-29T05:05:01Z
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