Spontaneous Gelation of Adhesive Catechol Modified Hyaluronic Acid and Chitosan

Spontaneously formed hydrogels are attracting increasing interest as injectable or wound dressing materials because they do not require additional reactions or toxic crosslinking reagents. Highly valuable properties such as low viscosity before external application, adequate filmogenic capacity, rap...

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Autores: Conejo Cuevas, Guillermo, Ruiz Rubio, Leire, Sáez Martínez, Virginia, Pérez González, Raúl, Gartziandia López de Goikoetxea, Oihane, Huguet Casquero, Amaia, Pérez Álvarez, Leyre
Tipo de documento: artigo
Data de publicação:2022
País:España
Recursos:Universidad del País Vasco
Repositório:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/56202
Acesso em linha:http://hdl.handle.net/10810/56202
Access Level:Acceso aberto
Palavra-chave:hyaluronic acid
chitosan
catechol
tissue adhesive
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spelling Spontaneous Gelation of Adhesive Catechol Modified Hyaluronic Acid and ChitosanConejo Cuevas, GuillermoRuiz Rubio, LeireSáez Martínez, VirginiaPérez González, RaúlGartziandia López de Goikoetxea, OihaneHuguet Casquero, AmaiaPérez Álvarez, Leyrehyaluronic acidchitosancatecholtissue adhesiveSpontaneously formed hydrogels are attracting increasing interest as injectable or wound dressing materials because they do not require additional reactions or toxic crosslinking reagents. Highly valuable properties such as low viscosity before external application, adequate filmogenic capacity, rapid gelation and tissue adhesion are required in order to use them for those therapeutic applications. In addition, biocompatibility and biodegradability are also mandatory. Accordingly, biopolymers, such as hyaluronic acid (HA) and chitosan (CHI), that have shown great potential for wound healing applications are excellent candidates due to their unique physiochemical and biological properties, such as moisturizing and antimicrobial ability, respectively. In this study, both biopolymers were modified by covalent anchoring of catechol groups, and the obtained hydrogels were characterized by studying, in particular, their tissue adhesiveness and film forming capacity for potential skin wound healing applications. Tissue adhesiveness was related to o-quinone formation over time and monitored by visible spectroscopy. Consequently, an opposite effect was observed for both polysaccharides. As gelation advances for HA-CA, it becomes more adhesive, while competitive reactions of quinone in CHI-CA slow down tissue adhesiveness and induce a detriment of the filmogenic properties.This research was funding by Basque Government (ELKARTEK program, Department of Development and Infrastructures of the Basque Country, KK-2021-00040), University of the Basque Country UPV/EHU (GIU 207075), Ministry of Economy, Industry and Competitiveness (grant MAT2017-89553-P), CDTI of the Ministry of Science and Innovation (Spain) (GAMMAREGEN INNO-20182003) and i+Med S. Coop.MDPI2022202220222022info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/56202reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MINECO/MAT2017-89553-P/https://www.mdpi.com/2073-4360/14/6/1209/htminfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).oai:addi.ehu.eus:10810/562022026-06-18T09:23:17Z
dc.title.none.fl_str_mv Spontaneous Gelation of Adhesive Catechol Modified Hyaluronic Acid and Chitosan
title Spontaneous Gelation of Adhesive Catechol Modified Hyaluronic Acid and Chitosan
spellingShingle Spontaneous Gelation of Adhesive Catechol Modified Hyaluronic Acid and Chitosan
Conejo Cuevas, Guillermo
hyaluronic acid
chitosan
catechol
tissue adhesive
title_short Spontaneous Gelation of Adhesive Catechol Modified Hyaluronic Acid and Chitosan
title_full Spontaneous Gelation of Adhesive Catechol Modified Hyaluronic Acid and Chitosan
title_fullStr Spontaneous Gelation of Adhesive Catechol Modified Hyaluronic Acid and Chitosan
title_full_unstemmed Spontaneous Gelation of Adhesive Catechol Modified Hyaluronic Acid and Chitosan
title_sort Spontaneous Gelation of Adhesive Catechol Modified Hyaluronic Acid and Chitosan
dc.creator.none.fl_str_mv Conejo Cuevas, Guillermo
Ruiz Rubio, Leire
Sáez Martínez, Virginia
Pérez González, Raúl
Gartziandia López de Goikoetxea, Oihane
Huguet Casquero, Amaia
Pérez Álvarez, Leyre
author Conejo Cuevas, Guillermo
author_facet Conejo Cuevas, Guillermo
Ruiz Rubio, Leire
Sáez Martínez, Virginia
Pérez González, Raúl
Gartziandia López de Goikoetxea, Oihane
Huguet Casquero, Amaia
Pérez Álvarez, Leyre
author_role author
author2 Ruiz Rubio, Leire
Sáez Martínez, Virginia
Pérez González, Raúl
Gartziandia López de Goikoetxea, Oihane
Huguet Casquero, Amaia
Pérez Álvarez, Leyre
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv hyaluronic acid
chitosan
catechol
tissue adhesive
topic hyaluronic acid
chitosan
catechol
tissue adhesive
description Spontaneously formed hydrogels are attracting increasing interest as injectable or wound dressing materials because they do not require additional reactions or toxic crosslinking reagents. Highly valuable properties such as low viscosity before external application, adequate filmogenic capacity, rapid gelation and tissue adhesion are required in order to use them for those therapeutic applications. In addition, biocompatibility and biodegradability are also mandatory. Accordingly, biopolymers, such as hyaluronic acid (HA) and chitosan (CHI), that have shown great potential for wound healing applications are excellent candidates due to their unique physiochemical and biological properties, such as moisturizing and antimicrobial ability, respectively. In this study, both biopolymers were modified by covalent anchoring of catechol groups, and the obtained hydrogels were characterized by studying, in particular, their tissue adhesiveness and film forming capacity for potential skin wound healing applications. Tissue adhesiveness was related to o-quinone formation over time and monitored by visible spectroscopy. Consequently, an opposite effect was observed for both polysaccharides. As gelation advances for HA-CA, it becomes more adhesive, while competitive reactions of quinone in CHI-CA slow down tissue adhesiveness and induce a detriment of the filmogenic properties.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/56202
url http://hdl.handle.net/10810/56202
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MINECO/MAT2017-89553-P/
https://www.mdpi.com/2073-4360/14/6/1209/htm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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