Effects of Polyphenol, measured by a biomarker of total polyphenols in urine, on cardiovascular risk factors After a long-term follow-up in the PREDIMED study

Several epidemiological studies have shown an inverse association between the consumption of polyphenol-rich foods and risk of cardiovascular diseases.However, accuracy and reliability of these studiesmay be increased using urinary total polyphenol excretion (TPE) as a biomarker for total polyphenol...

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Autores: Lamuela-Raventos, R.M. (Rosa Maria)|||/items/51521a3c-5376-4585-bb22-0f92268b1af0, Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6, Corella, D. (Dolores)|||/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41, Castañer, O. (Olga)|||/items/177ed76c-c237-4ac1-99b7-445c1b2e49dc, Medina-Remon, A. (Alexander)|||/items/279595ba-ef90-411e-bf84-293cf18fcf8b, Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7, Estruch, R. (Ramón)|||/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265, Tresserra-Rimbau, A. (Anna)|||/items/dfd06dd4-e0d8-429d-ba6c-e97ce396a46a, Guo, X. (Xiaohui)|||/items/fafa57b1-ae6f-4af5-baa4-1bd6821dc0cf
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/39923
Acceso en línea:https://hdl.handle.net/10171/39923
Access Level:acceso abierto
Palabra clave:Materias Investigacion::Ciencias de la Salud::Medicina preventiva
PREDIMED study
Long-term follow-up
Cardiovascular risk factors
Polyphenols in urine
Biomarker
Effects of Polyphenol
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spelling Effects of Polyphenol, measured by a biomarker of total polyphenols in urine, on cardiovascular risk factors After a long-term follow-up in the PREDIMED studyLamuela-Raventos, R.M. (Rosa Maria)|||/items/51521a3c-5376-4585-bb22-0f92268b1af0Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6Corella, D. (Dolores)|||/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41Castañer, O. (Olga)|||/items/177ed76c-c237-4ac1-99b7-445c1b2e49dcMedina-Remon, A. (Alexander)|||/items/279595ba-ef90-411e-bf84-293cf18fcf8bMartínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7Estruch, R. (Ramón)|||/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265Tresserra-Rimbau, A. (Anna)|||/items/dfd06dd4-e0d8-429d-ba6c-e97ce396a46aGuo, X. (Xiaohui)|||/items/fafa57b1-ae6f-4af5-baa4-1bd6821dc0cfMaterias Investigacion::Ciencias de la Salud::Medicina preventivaPREDIMED studyLong-term follow-upCardiovascular risk factorsPolyphenols in urineBiomarkerEffects of PolyphenolSeveral epidemiological studies have shown an inverse association between the consumption of polyphenol-rich foods and risk of cardiovascular diseases.However, accuracy and reliability of these studiesmay be increased using urinary total polyphenol excretion (TPE) as a biomarker for total polyphenol intake. Our aim was to assess if antioxidant activity, measured by a Folin-Ciocalteu assay in urine, is correlated with an improvement in cardiovascular risk factors (blood pressure and serum glucose, cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride concentrations) in an elderly population at high risk. A longitudinal study was performedwith573participants (aged67.3 ± 5.9) fromthe PREDIMED study (ISRCTN35739639).We used Folin-Ciocalteumethod to determine TPE in urine samples, assisting with solid phase extraction. Participants were categorized into three groups according to changes in TPE. Multiple linear regression models were used to assess relationships between TPE and clinical cardiovascular risk factors, adjusting for potential confounders. After a 5-year follow-up, significant inverse correlations were observed between changes in TPE and plasma triglyceride concentration ( = −8.563; = 0.007), glucose concentration ( = −4.164; = 0.036), and diastolic blood pressure ( = −1.316; = 0.013). Our results suggest that the consumption of more polyphenols, measured as TPE in urine, could exert a protective effect against some cardiovascular risk factors.Hindawi Publishing CorporationDadun. Depósito Académico Digital Universidad de Navarra20162016-02-1520162016-01-0120162016-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/39923reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/399232026-06-21T12:47:57Z
dc.title.none.fl_str_mv Effects of Polyphenol, measured by a biomarker of total polyphenols in urine, on cardiovascular risk factors After a long-term follow-up in the PREDIMED study
title Effects of Polyphenol, measured by a biomarker of total polyphenols in urine, on cardiovascular risk factors After a long-term follow-up in the PREDIMED study
spellingShingle Effects of Polyphenol, measured by a biomarker of total polyphenols in urine, on cardiovascular risk factors After a long-term follow-up in the PREDIMED study
Lamuela-Raventos, R.M. (Rosa Maria)|||/items/51521a3c-5376-4585-bb22-0f92268b1af0
Materias Investigacion::Ciencias de la Salud::Medicina preventiva
PREDIMED study
Long-term follow-up
Cardiovascular risk factors
Polyphenols in urine
Biomarker
Effects of Polyphenol
title_short Effects of Polyphenol, measured by a biomarker of total polyphenols in urine, on cardiovascular risk factors After a long-term follow-up in the PREDIMED study
title_full Effects of Polyphenol, measured by a biomarker of total polyphenols in urine, on cardiovascular risk factors After a long-term follow-up in the PREDIMED study
title_fullStr Effects of Polyphenol, measured by a biomarker of total polyphenols in urine, on cardiovascular risk factors After a long-term follow-up in the PREDIMED study
title_full_unstemmed Effects of Polyphenol, measured by a biomarker of total polyphenols in urine, on cardiovascular risk factors After a long-term follow-up in the PREDIMED study
title_sort Effects of Polyphenol, measured by a biomarker of total polyphenols in urine, on cardiovascular risk factors After a long-term follow-up in the PREDIMED study
dc.creator.none.fl_str_mv Lamuela-Raventos, R.M. (Rosa Maria)|||/items/51521a3c-5376-4585-bb22-0f92268b1af0
Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6
Corella, D. (Dolores)|||/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41
Castañer, O. (Olga)|||/items/177ed76c-c237-4ac1-99b7-445c1b2e49dc
Medina-Remon, A. (Alexander)|||/items/279595ba-ef90-411e-bf84-293cf18fcf8b
Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7
Estruch, R. (Ramón)|||/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265
Tresserra-Rimbau, A. (Anna)|||/items/dfd06dd4-e0d8-429d-ba6c-e97ce396a46a
Guo, X. (Xiaohui)|||/items/fafa57b1-ae6f-4af5-baa4-1bd6821dc0cf
author Lamuela-Raventos, R.M. (Rosa Maria)|||/items/51521a3c-5376-4585-bb22-0f92268b1af0
author_facet Lamuela-Raventos, R.M. (Rosa Maria)|||/items/51521a3c-5376-4585-bb22-0f92268b1af0
Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6
Corella, D. (Dolores)|||/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41
Castañer, O. (Olga)|||/items/177ed76c-c237-4ac1-99b7-445c1b2e49dc
Medina-Remon, A. (Alexander)|||/items/279595ba-ef90-411e-bf84-293cf18fcf8b
Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7
Estruch, R. (Ramón)|||/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265
Tresserra-Rimbau, A. (Anna)|||/items/dfd06dd4-e0d8-429d-ba6c-e97ce396a46a
Guo, X. (Xiaohui)|||/items/fafa57b1-ae6f-4af5-baa4-1bd6821dc0cf
author_role author
author2 Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6
Corella, D. (Dolores)|||/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41
Castañer, O. (Olga)|||/items/177ed76c-c237-4ac1-99b7-445c1b2e49dc
Medina-Remon, A. (Alexander)|||/items/279595ba-ef90-411e-bf84-293cf18fcf8b
Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7
Estruch, R. (Ramón)|||/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265
Tresserra-Rimbau, A. (Anna)|||/items/dfd06dd4-e0d8-429d-ba6c-e97ce396a46a
Guo, X. (Xiaohui)|||/items/fafa57b1-ae6f-4af5-baa4-1bd6821dc0cf
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Materias Investigacion::Ciencias de la Salud::Medicina preventiva
PREDIMED study
Long-term follow-up
Cardiovascular risk factors
Polyphenols in urine
Biomarker
Effects of Polyphenol
topic Materias Investigacion::Ciencias de la Salud::Medicina preventiva
PREDIMED study
Long-term follow-up
Cardiovascular risk factors
Polyphenols in urine
Biomarker
Effects of Polyphenol
description Several epidemiological studies have shown an inverse association between the consumption of polyphenol-rich foods and risk of cardiovascular diseases.However, accuracy and reliability of these studiesmay be increased using urinary total polyphenol excretion (TPE) as a biomarker for total polyphenol intake. Our aim was to assess if antioxidant activity, measured by a Folin-Ciocalteu assay in urine, is correlated with an improvement in cardiovascular risk factors (blood pressure and serum glucose, cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride concentrations) in an elderly population at high risk. A longitudinal study was performedwith573participants (aged67.3 ± 5.9) fromthe PREDIMED study (ISRCTN35739639).We used Folin-Ciocalteumethod to determine TPE in urine samples, assisting with solid phase extraction. Participants were categorized into three groups according to changes in TPE. Multiple linear regression models were used to assess relationships between TPE and clinical cardiovascular risk factors, adjusting for potential confounders. After a 5-year follow-up, significant inverse correlations were observed between changes in TPE and plasma triglyceride concentration ( = −8.563; = 0.007), glucose concentration ( = −4.164; = 0.036), and diastolic blood pressure ( = −1.316; = 0.013). Our results suggest that the consumption of more polyphenols, measured as TPE in urine, could exert a protective effect against some cardiovascular risk factors.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-02-15
2016
2016-01-01
2016
2016-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/39923
url https://hdl.handle.net/10171/39923
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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