A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVF

RESEARCH QUESTION: Does clinical performance of personalized embryo transfer (PET) guided by endometrial receptivity analysis (ERA) differ from frozen embryo transfer (FET) or fresh embryo transfer in infertile patients undergoing IVF?; DESIGN: Multicentre, open-label randomized controlled trial; 45...

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Autores: Simon, Carlos, Gomez, Carlos, Cabanillas, Sergio, Vladimirov, Iavor, Castillon, Gemma, Giles, Juan, Boynukalin, Kubra, Findikli, Necati, Bahceci, Mustafa, Ortega, Israel, Vidal, Carmina, Funabiki, Miyako, Izquierdo, Alexandra, Lopez, Lourdes, Portela, Susana, Frantz, Nilo, Kulmann, Marcos, Taguchi, Sagiri, Labarta, Elena, Colucci, Francisco, Mackens, Shari, Santamaria, Xavier, Munoz, Elkin, Barrera, Saul, Garcia-Velasco, Juan Antonio, Fernandez, Manuel, Ferrando, Marcos, Ruiz, Maria, Mol, Ben W, Valbuena, Diana, ERA-RCT Study Consortium Group
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p4696
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/4696
Access Level:acceso abierto
Palabra clave:Endometrial receptivity
Endometrial receptivity analysis (ERA)
Fresh embryo transfer (ET)
Frozen embryo transfer (FET)
Personalized embryo transfer (PET)
Window of implantation (WOI)
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spelling A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVFSimon, CarlosGomez, CarlosCabanillas, SergioVladimirov, IavorCastillon, GemmaGiles, JuanBoynukalin, KubraFindikli, NecatiBahceci, MustafaOrtega, IsraelVidal, CarminaFunabiki, MiyakoIzquierdo, AlexandraLopez, LourdesPortela, SusanaFrantz, NiloKulmann, MarcosTaguchi, SagiriLabarta, ElenaColucci, FranciscoMackens, ShariSantamaria, XavierMunoz, ElkinBarrera, SaulGarcia-Velasco, Juan AntonioFernandez, ManuelFerrando, MarcosRuiz, MariaMol, Ben WValbuena, DianaERA-RCT Study Consortium GroupEndometrial receptivityEndometrial receptivity analysis (ERA)Fresh embryo transfer (ET)Frozen embryo transfer (FET)Personalized embryo transfer (PET)Window of implantation (WOI)RESEARCH QUESTION: Does clinical performance of personalized embryo transfer (PET) guided by endometrial receptivity analysis (ERA) differ from frozen embryo transfer (FET) or fresh embryo transfer in infertile patients undergoing IVF?; DESIGN: Multicentre, open-label randomized controlled trial; 458 patients aged 37 years or younger undergoing IVF with blastocyst transfer at first appointment were randomized to PET guided by ERA, FET or fresh embryo transfer in 16 reproductive clinics.; RESULTS: Clinical outcomes by intention-to-treat analysis were comparable, but cumulative pregnancy rate was significantly higher in the PET (93.6%) compared with FET (79.7%) (P?=?0.0005) and fresh embryo transfer groups (80.7%) (P?=?0.0013). Analysis per protocol demonstrates that live birth rates at first embryo transfer were 56.2% in PET versus 42.4% in FET (P?=?0.09), and 45.7% in fresh embryo transfer groups (P?=?0.17). Cumulative live birth rates after 12 months were 71.2% in PET versus 55.4% in FET (P?=?0.04), and 48.9% in fresh embryo transfer (P?=?0.003). Pregnancy rates at the first embryo transfer in PET, FET and fresh embryo transfer arms were 72.5% versus 54.3% (P?=?0.01) and 58.5% (P?=?0.05), respectively. Implantation rates at first embryo transfer were 57.3% versus 43.2% (P?=?0.03), and 38.6% (P?=?0.004), respectively. Obstetrical outcomes, type of delivery and neonatal outcomes were similar in all groups.; CONCLUSIONS: Despite 50% of patients dropping out compared with 30% initially planned, per protocol analysis demonstrates statistically significant improvement in pregnancy, implantation and cumulative live birth rates in PET compared with FET and fresh embryo transfer arms, indicating the potential utility of PET guided by the ERA test at the first appointment. Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.ELSEVIER SCI LTD2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/4696REPRODUCTIVE BIOMEDICINE ONLINEISSN: 14726483ISSNe: 14726491reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p46962026-06-07T16:35:31Z
dc.title.none.fl_str_mv A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVF
title A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVF
spellingShingle A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVF
Simon, Carlos
Endometrial receptivity
Endometrial receptivity analysis (ERA)
Fresh embryo transfer (ET)
Frozen embryo transfer (FET)
Personalized embryo transfer (PET)
Window of implantation (WOI)
title_short A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVF
title_full A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVF
title_fullStr A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVF
title_full_unstemmed A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVF
title_sort A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVF
dc.creator.none.fl_str_mv Simon, Carlos
Gomez, Carlos
Cabanillas, Sergio
Vladimirov, Iavor
Castillon, Gemma
Giles, Juan
Boynukalin, Kubra
Findikli, Necati
Bahceci, Mustafa
Ortega, Israel
Vidal, Carmina
Funabiki, Miyako
Izquierdo, Alexandra
Lopez, Lourdes
Portela, Susana
Frantz, Nilo
Kulmann, Marcos
Taguchi, Sagiri
Labarta, Elena
Colucci, Francisco
Mackens, Shari
Santamaria, Xavier
Munoz, Elkin
Barrera, Saul
Garcia-Velasco, Juan Antonio
Fernandez, Manuel
Ferrando, Marcos
Ruiz, Maria
Mol, Ben W
Valbuena, Diana
ERA-RCT Study Consortium Group
author Simon, Carlos
author_facet Simon, Carlos
Gomez, Carlos
Cabanillas, Sergio
Vladimirov, Iavor
Castillon, Gemma
Giles, Juan
Boynukalin, Kubra
Findikli, Necati
Bahceci, Mustafa
Ortega, Israel
Vidal, Carmina
Funabiki, Miyako
Izquierdo, Alexandra
Lopez, Lourdes
Portela, Susana
Frantz, Nilo
Kulmann, Marcos
Taguchi, Sagiri
Labarta, Elena
Colucci, Francisco
Mackens, Shari
Santamaria, Xavier
Munoz, Elkin
Barrera, Saul
Garcia-Velasco, Juan Antonio
Fernandez, Manuel
Ferrando, Marcos
Ruiz, Maria
Mol, Ben W
Valbuena, Diana
ERA-RCT Study Consortium Group
author_role author
author2 Gomez, Carlos
Cabanillas, Sergio
Vladimirov, Iavor
Castillon, Gemma
Giles, Juan
Boynukalin, Kubra
Findikli, Necati
Bahceci, Mustafa
Ortega, Israel
Vidal, Carmina
Funabiki, Miyako
Izquierdo, Alexandra
Lopez, Lourdes
Portela, Susana
Frantz, Nilo
Kulmann, Marcos
Taguchi, Sagiri
Labarta, Elena
Colucci, Francisco
Mackens, Shari
Santamaria, Xavier
Munoz, Elkin
Barrera, Saul
Garcia-Velasco, Juan Antonio
Fernandez, Manuel
Ferrando, Marcos
Ruiz, Maria
Mol, Ben W
Valbuena, Diana
ERA-RCT Study Consortium Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Endometrial receptivity
Endometrial receptivity analysis (ERA)
Fresh embryo transfer (ET)
Frozen embryo transfer (FET)
Personalized embryo transfer (PET)
Window of implantation (WOI)
topic Endometrial receptivity
Endometrial receptivity analysis (ERA)
Fresh embryo transfer (ET)
Frozen embryo transfer (FET)
Personalized embryo transfer (PET)
Window of implantation (WOI)
description RESEARCH QUESTION: Does clinical performance of personalized embryo transfer (PET) guided by endometrial receptivity analysis (ERA) differ from frozen embryo transfer (FET) or fresh embryo transfer in infertile patients undergoing IVF?; DESIGN: Multicentre, open-label randomized controlled trial; 458 patients aged 37 years or younger undergoing IVF with blastocyst transfer at first appointment were randomized to PET guided by ERA, FET or fresh embryo transfer in 16 reproductive clinics.; RESULTS: Clinical outcomes by intention-to-treat analysis were comparable, but cumulative pregnancy rate was significantly higher in the PET (93.6%) compared with FET (79.7%) (P?=?0.0005) and fresh embryo transfer groups (80.7%) (P?=?0.0013). Analysis per protocol demonstrates that live birth rates at first embryo transfer were 56.2% in PET versus 42.4% in FET (P?=?0.09), and 45.7% in fresh embryo transfer groups (P?=?0.17). Cumulative live birth rates after 12 months were 71.2% in PET versus 55.4% in FET (P?=?0.04), and 48.9% in fresh embryo transfer (P?=?0.003). Pregnancy rates at the first embryo transfer in PET, FET and fresh embryo transfer arms were 72.5% versus 54.3% (P?=?0.01) and 58.5% (P?=?0.05), respectively. Implantation rates at first embryo transfer were 57.3% versus 43.2% (P?=?0.03), and 38.6% (P?=?0.004), respectively. Obstetrical outcomes, type of delivery and neonatal outcomes were similar in all groups.; CONCLUSIONS: Despite 50% of patients dropping out compared with 30% initially planned, per protocol analysis demonstrates statistically significant improvement in pregnancy, implantation and cumulative live birth rates in PET compared with FET and fresh embryo transfer arms, indicating the potential utility of PET guided by the ERA test at the first appointment. Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/4696
url https://incliva.portalinvestigacion.com/publicaciones/4696
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCI LTD
publisher.none.fl_str_mv ELSEVIER SCI LTD
dc.source.none.fl_str_mv REPRODUCTIVE BIOMEDICINE ONLINE
ISSN: 14726483
ISSNe: 14726491
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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