Gray matter vulnerabilities predict longitudinal development of apathy in Huntington's disease

Background: Apathy, a common neuropsychiatric disturbance in Huntington's disease (HD), is subserved by a complex neurobiological network. However, no study has yet employed a whole-brain approach to examine underlying regional vulnerabilities that may precipitate apathy changes over time. Obje...

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Autores: De Paepe, Audrey E., Ara, Alberto, García-Gorro, Clara, Martínez Horta, Saúl, Pérez Pérez, Jesús, Kulisevsky, Jaime, Rodríguez Dechichá, Nadia, Vaquer, Irene, Subirà Álvarez, Susana, Calopa, Matilde, Muñoz García, José Esteban, Santacruz, Pilar, Ruiz-Idiago, Jesús, Mareca, Celia, Diego Balaguer, Ruth de, Camara Mancha, Estela
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/181202
Acceso en línea:https://hdl.handle.net/2445/181202
Access Level:acceso abierto
Palabra clave:Corea de Huntington
Malalties neurodegeneratives
Cervell
Imatges per ressonància magnètica
Huntington's chorea
Neurodegenerative Diseases
Brain
Magnetic resonance imaging
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repository_id_str
spelling Gray matter vulnerabilities predict longitudinal development of apathy in Huntington's diseaseDe Paepe, Audrey E.Ara, AlbertoGarcía-Gorro, ClaraMartínez Horta, SaúlPérez Pérez, JesúsKulisevsky, JaimeRodríguez Dechichá, NadiaVaquer, IreneSubirà Álvarez, SusanaCalopa, MatildeMuñoz García, José EstebanSantacruz, PilarRuiz-Idiago, JesúsMareca, CeliaDiego Balaguer, Ruth deCamara Mancha, EstelaCorea de HuntingtonMalalties neurodegenerativesCervellImatges per ressonància magnèticaHuntington's choreaNeurodegenerative DiseasesBrainMagnetic resonance imagingBackground: Apathy, a common neuropsychiatric disturbance in Huntington's disease (HD), is subserved by a complex neurobiological network. However, no study has yet employed a whole-brain approach to examine underlying regional vulnerabilities that may precipitate apathy changes over time. Objectives: To identify whole-brain gray matter volume (GMV) vulnerabilities that may predict longitudinal apathy development in HD. Methods: Forty-five HD individuals (31 female) were scanned and evaluated for apathy and other neuropsychiatric features using the short-Problem Behavior Assessment for a maximum total of six longitudinal visits (including baseline). In order to identify regions where changes in GMV may describe changes in apathy, we performed longitudinal voxel-based morphometry (VBM) on those 33 participants with a magnetic resonance imaging (MRI) scan on their second visit at 18 ± 6 months follow-up (78 MRI datasets). We next employed a generalized linear mixed-effects model (N = 45) to elucidate whether initial and specific GMV may predict apathy development over time. Results: Utilizing longitudinal VBM, we revealed a relationship between increases in apathy and specific GMV atrophy in the right middle cingulate cortex (MCC). Furthermore, vulnerability in the right MCC volume at baseline successfully predicted the severity and progression of apathy over time. Conclusions: This study highlights that individual differences in apathy in HD may be explained by variability in atrophy and initial vulnerabilities in the right MCC, a region implicated in action-initiation. These findings thus serve to facilitate the prediction of an apathetic profile, permitting targeted, time-sensitive interventions in neurodegenerative disease with potential implications in otherwise healthy populations.Wiley2021202220212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion11 p.application/pdfhttps://hdl.handle.net/2445/181202Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1002/mds.28638Movement Disorders, 2021, vol. 36, num. 9, p. 2162-2172https://doi.org/10.1002/mds.28638(c) International Parkinson and Movement Disorder Society, 2021info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1812022026-05-29T05:05:01Z
dc.title.none.fl_str_mv Gray matter vulnerabilities predict longitudinal development of apathy in Huntington's disease
title Gray matter vulnerabilities predict longitudinal development of apathy in Huntington's disease
spellingShingle Gray matter vulnerabilities predict longitudinal development of apathy in Huntington's disease
De Paepe, Audrey E.
Corea de Huntington
Malalties neurodegeneratives
Cervell
Imatges per ressonància magnètica
Huntington's chorea
Neurodegenerative Diseases
Brain
Magnetic resonance imaging
title_short Gray matter vulnerabilities predict longitudinal development of apathy in Huntington's disease
title_full Gray matter vulnerabilities predict longitudinal development of apathy in Huntington's disease
title_fullStr Gray matter vulnerabilities predict longitudinal development of apathy in Huntington's disease
title_full_unstemmed Gray matter vulnerabilities predict longitudinal development of apathy in Huntington's disease
title_sort Gray matter vulnerabilities predict longitudinal development of apathy in Huntington's disease
dc.creator.none.fl_str_mv De Paepe, Audrey E.
Ara, Alberto
García-Gorro, Clara
Martínez Horta, Saúl
Pérez Pérez, Jesús
Kulisevsky, Jaime
Rodríguez Dechichá, Nadia
Vaquer, Irene
Subirà Álvarez, Susana
Calopa, Matilde
Muñoz García, José Esteban
Santacruz, Pilar
Ruiz-Idiago, Jesús
Mareca, Celia
Diego Balaguer, Ruth de
Camara Mancha, Estela
author De Paepe, Audrey E.
author_facet De Paepe, Audrey E.
Ara, Alberto
García-Gorro, Clara
Martínez Horta, Saúl
Pérez Pérez, Jesús
Kulisevsky, Jaime
Rodríguez Dechichá, Nadia
Vaquer, Irene
Subirà Álvarez, Susana
Calopa, Matilde
Muñoz García, José Esteban
Santacruz, Pilar
Ruiz-Idiago, Jesús
Mareca, Celia
Diego Balaguer, Ruth de
Camara Mancha, Estela
author_role author
author2 Ara, Alberto
García-Gorro, Clara
Martínez Horta, Saúl
Pérez Pérez, Jesús
Kulisevsky, Jaime
Rodríguez Dechichá, Nadia
Vaquer, Irene
Subirà Álvarez, Susana
Calopa, Matilde
Muñoz García, José Esteban
Santacruz, Pilar
Ruiz-Idiago, Jesús
Mareca, Celia
Diego Balaguer, Ruth de
Camara Mancha, Estela
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Corea de Huntington
Malalties neurodegeneratives
Cervell
Imatges per ressonància magnètica
Huntington's chorea
Neurodegenerative Diseases
Brain
Magnetic resonance imaging
topic Corea de Huntington
Malalties neurodegeneratives
Cervell
Imatges per ressonància magnètica
Huntington's chorea
Neurodegenerative Diseases
Brain
Magnetic resonance imaging
description Background: Apathy, a common neuropsychiatric disturbance in Huntington's disease (HD), is subserved by a complex neurobiological network. However, no study has yet employed a whole-brain approach to examine underlying regional vulnerabilities that may precipitate apathy changes over time. Objectives: To identify whole-brain gray matter volume (GMV) vulnerabilities that may predict longitudinal apathy development in HD. Methods: Forty-five HD individuals (31 female) were scanned and evaluated for apathy and other neuropsychiatric features using the short-Problem Behavior Assessment for a maximum total of six longitudinal visits (including baseline). In order to identify regions where changes in GMV may describe changes in apathy, we performed longitudinal voxel-based morphometry (VBM) on those 33 participants with a magnetic resonance imaging (MRI) scan on their second visit at 18 ± 6 months follow-up (78 MRI datasets). We next employed a generalized linear mixed-effects model (N = 45) to elucidate whether initial and specific GMV may predict apathy development over time. Results: Utilizing longitudinal VBM, we revealed a relationship between increases in apathy and specific GMV atrophy in the right middle cingulate cortex (MCC). Furthermore, vulnerability in the right MCC volume at baseline successfully predicted the severity and progression of apathy over time. Conclusions: This study highlights that individual differences in apathy in HD may be explained by variability in atrophy and initial vulnerabilities in the right MCC, a region implicated in action-initiation. These findings thus serve to facilitate the prediction of an apathetic profile, permitting targeted, time-sensitive interventions in neurodegenerative disease with potential implications in otherwise healthy populations.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/181202
url https://hdl.handle.net/2445/181202
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1002/mds.28638
Movement Disorders, 2021, vol. 36, num. 9, p. 2162-2172
https://doi.org/10.1002/mds.28638
dc.rights.none.fl_str_mv (c) International Parkinson and Movement Disorder Society, 2021
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) International Parkinson and Movement Disorder Society, 2021
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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