Serological autoimmune profile of systemic lupus erythematosus in deep and non-deep endometriosis patients

Several studies have reported a high prevalence of autoimmune diseases such as systemic lupus erythematosus (SLE) in endometriosis patients. The aim of this study was to evaluate the SLE autoimmune antibody profile in patients with deep (DE) and non-deep endometriosis (Non-DE).Four groups of premeno...

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Autores: Coloma, José Luis, Martínez Zamora, María Ángeles, Tàssies Penella, María Dolores, Reverter Calatayud, Juan Carlos, Espinosa Garriga, Gerard, Cervera i Segura, Ricard, 1960-, Carmona Herrera, Francisco
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/207223
Acceso en línea:https://hdl.handle.net/2445/207223
Access Level:acceso abierto
Palabra clave:Astènia
Endometriosi
Asthenia
Endometriosis
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spelling Serological autoimmune profile of systemic lupus erythematosus in deep and non-deep endometriosis patientsColoma, José LuisMartínez Zamora, María ÁngelesTàssies Penella, María DoloresReverter Calatayud, Juan CarlosEspinosa Garriga, GerardCervera i Segura, Ricard, 1960-Carmona Herrera, FranciscoAstèniaEndometriosiAstheniaEndometriosisSeveral studies have reported a high prevalence of autoimmune diseases such as systemic lupus erythematosus (SLE) in endometriosis patients. The aim of this study was to evaluate the SLE autoimmune antibody profile in patients with deep (DE) and non-deep endometriosis (Non-DE).Four groups of premenopausal patients were evaluated: patients with DE (n = 50); patients with ovarian endometriomas (Non-DE; n = 50); healthy patients without endometriosis (C group; n = 45); and SLE patients without endometriosis (SLE group; N = 46). Blood samples were obtained and the standard SLE autoimmune profile was evaluated in all patients. Pain symptoms related to endometriosis and clinical SLE manifestations were also recorded.The DE group presented a statistically significant higher proportion of patients with antinuclear antibodies (ANA) (20%) compared to the Non-DE group (4%) and C group (2.2%). Levels of complement were more frequently lower among DE and Non-DE patients although differences did not reach statistical significance. Similarly, anti-dsDNA antibodies and anticoagulant lupus were positive in more patients of the DE group but did not reach statistical significance. The DE group complained of more arthralgia and asthenia compared to the Non-DE and C groups.The results of this study showed higher positivity of ANA and greater arthralgia and asthenia in patients with DE compared with Non-DE patients and healthy controls, suggesting that they may have a higher susceptibility to autoimmune diseases and present more generalized pain.Copyright © 2023. Published by Elsevier B.V.Elsevier B. V.2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/207223Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.jri.2023.103827Journal Of Reproductive Immunology, 2023, vol. 156, p. 103827https://doi.org/10.1016/j.jri.2023.103827cc by-nc-nd (c) Elsevier, 2023http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2072232026-05-27T06:46:51Z
dc.title.none.fl_str_mv Serological autoimmune profile of systemic lupus erythematosus in deep and non-deep endometriosis patients
title Serological autoimmune profile of systemic lupus erythematosus in deep and non-deep endometriosis patients
spellingShingle Serological autoimmune profile of systemic lupus erythematosus in deep and non-deep endometriosis patients
Coloma, José Luis
Astènia
Endometriosi
Asthenia
Endometriosis
title_short Serological autoimmune profile of systemic lupus erythematosus in deep and non-deep endometriosis patients
title_full Serological autoimmune profile of systemic lupus erythematosus in deep and non-deep endometriosis patients
title_fullStr Serological autoimmune profile of systemic lupus erythematosus in deep and non-deep endometriosis patients
title_full_unstemmed Serological autoimmune profile of systemic lupus erythematosus in deep and non-deep endometriosis patients
title_sort Serological autoimmune profile of systemic lupus erythematosus in deep and non-deep endometriosis patients
dc.creator.none.fl_str_mv Coloma, José Luis
Martínez Zamora, María Ángeles
Tàssies Penella, María Dolores
Reverter Calatayud, Juan Carlos
Espinosa Garriga, Gerard
Cervera i Segura, Ricard, 1960-
Carmona Herrera, Francisco
author Coloma, José Luis
author_facet Coloma, José Luis
Martínez Zamora, María Ángeles
Tàssies Penella, María Dolores
Reverter Calatayud, Juan Carlos
Espinosa Garriga, Gerard
Cervera i Segura, Ricard, 1960-
Carmona Herrera, Francisco
author_role author
author2 Martínez Zamora, María Ángeles
Tàssies Penella, María Dolores
Reverter Calatayud, Juan Carlos
Espinosa Garriga, Gerard
Cervera i Segura, Ricard, 1960-
Carmona Herrera, Francisco
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Astènia
Endometriosi
Asthenia
Endometriosis
topic Astènia
Endometriosi
Asthenia
Endometriosis
description Several studies have reported a high prevalence of autoimmune diseases such as systemic lupus erythematosus (SLE) in endometriosis patients. The aim of this study was to evaluate the SLE autoimmune antibody profile in patients with deep (DE) and non-deep endometriosis (Non-DE).Four groups of premenopausal patients were evaluated: patients with DE (n = 50); patients with ovarian endometriomas (Non-DE; n = 50); healthy patients without endometriosis (C group; n = 45); and SLE patients without endometriosis (SLE group; N = 46). Blood samples were obtained and the standard SLE autoimmune profile was evaluated in all patients. Pain symptoms related to endometriosis and clinical SLE manifestations were also recorded.The DE group presented a statistically significant higher proportion of patients with antinuclear antibodies (ANA) (20%) compared to the Non-DE group (4%) and C group (2.2%). Levels of complement were more frequently lower among DE and Non-DE patients although differences did not reach statistical significance. Similarly, anti-dsDNA antibodies and anticoagulant lupus were positive in more patients of the DE group but did not reach statistical significance. The DE group complained of more arthralgia and asthenia compared to the Non-DE and C groups.The results of this study showed higher positivity of ANA and greater arthralgia and asthenia in patients with DE compared with Non-DE patients and healthy controls, suggesting that they may have a higher susceptibility to autoimmune diseases and present more generalized pain.Copyright © 2023. Published by Elsevier B.V.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/207223
url https://hdl.handle.net/2445/207223
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.jri.2023.103827
Journal Of Reproductive Immunology, 2023, vol. 156, p. 103827
https://doi.org/10.1016/j.jri.2023.103827
dc.rights.none.fl_str_mv cc by-nc-nd (c) Elsevier, 2023
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Elsevier, 2023
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B. V.
publisher.none.fl_str_mv Elsevier B. V.
dc.source.none.fl_str_mv Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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