Links between genome replication and chromatin landscapes

© 2015 The Authors. Post-embryonic organogenesis in plants requires the continuous production of cells in the organ primordia, their expansion and a coordinated exit to differentiation. Genome replication is one of the most important processes that occur during the cell cycle, as the maintenance of...

Descripción completa

Detalles Bibliográficos
Autores: Sequeira-Mendes, Joana, Gutiérrez Armenta, Crisanto
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/139578
Acceso en línea:http://hdl.handle.net/10261/139578
Access Level:acceso abierto
Palabra clave:epigenetics
plant
Arabidopsis thaliana
Chromatin
DNA replication
id ES_fb84b73deaaabe9920706af5cf2c9efd
oai_identifier_str oai:digital.csic.es:10261/139578
network_acronym_str ES
network_name_str España
repository_id_str
spelling Links between genome replication and chromatin landscapesSequeira-Mendes, JoanaGutiérrez Armenta, CrisantoepigeneticsplantArabidopsis thalianaChromatinDNA replication© 2015 The Authors. Post-embryonic organogenesis in plants requires the continuous production of cells in the organ primordia, their expansion and a coordinated exit to differentiation. Genome replication is one of the most important processes that occur during the cell cycle, as the maintenance of genomic integrity is of primary relevance for development. As it is chromatin that must be duplicated, a strict coordination occurs between DNA replication, the deposition of new histones, and the introduction of histone modifications and variants. In turn, the chromatin landscape affects several stages during genome replication. Thus, chromatin accessibility is crucial for the initial stages and to specify the location of DNA replication origins with different chromatin signatures. The chromatin landscape also determines the timing of activation during the S phase. Genome replication must occur fully, but only once during each cell cycle. The re-replication avoidance mechanisms rely primarily on restricting the availability of certain replication factors; however, the presence of specific histone modifications are also revealed as contributing to the mechanisms that avoid re-replication, in particular for heterochromatin replication. We provide here an update of genome replication mostly focused on data from Arabidopsis, and the advances that genomic approaches are likely to provide in the coming years. The data available, both in plants and animals, point to the relevance of the chromatin landscape in genome replication, and require a critical evaluation of the existing views about the nature of replication origins, the mechanisms of origin specification and the relevance of epigenetic modifications for genome replication. Significance Statement The chromatin lanscape has a direct impact on genome replication at various levels including specification of replication origins, replication timing and the maintenance of genome integrity.MINECO and by an institutional grant from Fundación Ramón Areces to the Centro de Biologia Molecular Severo Ochoa.Peer ReviewedBlackwell PublishingMinisterio de Economía y Competitividad (España)Fundación Ramón ArecesConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2016201620152016info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/139578reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1395782026-05-22T06:33:51Z
dc.title.none.fl_str_mv Links between genome replication and chromatin landscapes
title Links between genome replication and chromatin landscapes
spellingShingle Links between genome replication and chromatin landscapes
Sequeira-Mendes, Joana
epigenetics
plant
Arabidopsis thaliana
Chromatin
DNA replication
title_short Links between genome replication and chromatin landscapes
title_full Links between genome replication and chromatin landscapes
title_fullStr Links between genome replication and chromatin landscapes
title_full_unstemmed Links between genome replication and chromatin landscapes
title_sort Links between genome replication and chromatin landscapes
dc.creator.none.fl_str_mv Sequeira-Mendes, Joana
Gutiérrez Armenta, Crisanto
author Sequeira-Mendes, Joana
author_facet Sequeira-Mendes, Joana
Gutiérrez Armenta, Crisanto
author_role author
author2 Gutiérrez Armenta, Crisanto
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Fundación Ramón Areces
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv epigenetics
plant
Arabidopsis thaliana
Chromatin
DNA replication
topic epigenetics
plant
Arabidopsis thaliana
Chromatin
DNA replication
description © 2015 The Authors. Post-embryonic organogenesis in plants requires the continuous production of cells in the organ primordia, their expansion and a coordinated exit to differentiation. Genome replication is one of the most important processes that occur during the cell cycle, as the maintenance of genomic integrity is of primary relevance for development. As it is chromatin that must be duplicated, a strict coordination occurs between DNA replication, the deposition of new histones, and the introduction of histone modifications and variants. In turn, the chromatin landscape affects several stages during genome replication. Thus, chromatin accessibility is crucial for the initial stages and to specify the location of DNA replication origins with different chromatin signatures. The chromatin landscape also determines the timing of activation during the S phase. Genome replication must occur fully, but only once during each cell cycle. The re-replication avoidance mechanisms rely primarily on restricting the availability of certain replication factors; however, the presence of specific histone modifications are also revealed as contributing to the mechanisms that avoid re-replication, in particular for heterochromatin replication. We provide here an update of genome replication mostly focused on data from Arabidopsis, and the advances that genomic approaches are likely to provide in the coming years. The data available, both in plants and animals, point to the relevance of the chromatin landscape in genome replication, and require a critical evaluation of the existing views about the nature of replication origins, the mechanisms of origin specification and the relevance of epigenetic modifications for genome replication. Significance Statement The chromatin lanscape has a direct impact on genome replication at various levels including specification of replication origins, replication timing and the maintenance of genome integrity.
publishDate 2015
dc.date.none.fl_str_mv 2015
2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/139578
url http://hdl.handle.net/10261/139578
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Blackwell Publishing
publisher.none.fl_str_mv Blackwell Publishing
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869425336203083776
score 15,811543

Similares en LA Referencia