Fe3O4-SiO2 mesoporous core/shell nanoparticles for magnetic field-induced ibuprofen-controlled release

Hybrid magnetic nanoparticles made up of an iron oxide, Fe3O4, core and a mesoporous SiO2 shell with high magnetization and a large surface area were proposed as an efficient drug delivery platform. The core/shell structure was synthesized by two seed-mediated growth steps combining solvothermal and...

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Autores: García Rodríguez, Lucía, Garayo Urabayen, Eneko, López Ortega, Alberto, Galarreta Rodríguez, Itziar, Cervera Gabalda, Laura María, Cruz Quesada, Guillermo, Cornejo Ibergallartu, Alfonso, Garrido Segovia, Julián José, Gómez Polo, Cristina, Pérez de Landazábal Berganzo, José Ignacio
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2022
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/53095
Acceso en línea:https://hdl.handle.net/2454/53095
Access Level:acceso abierto
Palabra clave:Drug release
Hyperthermia
Magnetic properties
Nanoparticles
Silica
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spelling Fe3O4-SiO2 mesoporous core/shell nanoparticles for magnetic field-induced ibuprofen-controlled releaseGarcía Rodríguez, LucíaGarayo Urabayen, EnekoLópez Ortega, AlbertoGalarreta Rodríguez, ItziarCervera Gabalda, Laura MaríaCruz Quesada, GuillermoCornejo Ibergallartu, AlfonsoGarrido Segovia, Julián JoséGómez Polo, CristinaPérez de Landazábal Berganzo, José IgnacioDrug releaseHyperthermiaMagnetic propertiesNanoparticlesSilicaHybrid magnetic nanoparticles made up of an iron oxide, Fe3O4, core and a mesoporous SiO2 shell with high magnetization and a large surface area were proposed as an efficient drug delivery platform. The core/shell structure was synthesized by two seed-mediated growth steps combining solvothermal and sol—gel approaches and using organic molecules as a porous scaffolding template. The system presents a mean particle diameter of 30(5) nm (9 nm magnetic core diameter and 10 nm silica shell thickness) with superparamagnetic behavior, saturation magnetization of 32 emu/g, and a significant AC magnetic-field-induced heating response (SAR = 63 W/gFe3O4, measured at an amplitude of 400 Oe and a frequency of 307 kHz). Using ibuprofen as a model drug, the specific surface area (231 m2/g) of the porous structure exhibits a high molecule loading capacity (10 wt %), and controlled drug release efficiency (67%) can be achieved using the external AC magnetic field for short time periods (5 min), showing faster and higher drug desorption compared to that of similar stimulus-responsive iron oxide-based nanocarriers. In addition, it is demonstrated that the magnetic field-induced drug release shows higher efficiency compared to that of the sustained release at fixed temperatures (47 and 53% for 37 and 42 °C, respectively), considering that the maximum temperature reached during the exposure to the magnetic field is well below (31 °C). Therefore, it can be hypothesized that short periods of exposure to the oscillating field induce much greater heating within the nanoparticles than in the external solution.A grant was funded within the framework of "Ayudas para la contratación de personal investigador y tecnológico 2020", Navarra Governement. The Spanish government is acknowledged for the HIPERNANO research network (RED2018-555102626-T). The authors gratefully acknowledge the financial support received from "Ministerio de Ciencia e Innovación" from Spain (PID2020-113558RB-C42). A.L.-O. acknowledges support from the Universidad Pública de Navarra (grant no. PJUPNA2020).American Chemical SocietyCienciasZientziakInstitute for Advanced Materials and Mathematics - INAMAT2Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa, PJUPNA2020Gobierno de Navarra / Nafarroako Gobernua2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2454/53095reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113558RB-C42info:eu-repo/grantAgreement/AEI/RED2018-555102626-T/© 2022 American Chemical Society.info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/530952026-06-17T12:41:47Z
dc.title.none.fl_str_mv Fe3O4-SiO2 mesoporous core/shell nanoparticles for magnetic field-induced ibuprofen-controlled release
title Fe3O4-SiO2 mesoporous core/shell nanoparticles for magnetic field-induced ibuprofen-controlled release
spellingShingle Fe3O4-SiO2 mesoporous core/shell nanoparticles for magnetic field-induced ibuprofen-controlled release
García Rodríguez, Lucía
Drug release
Hyperthermia
Magnetic properties
Nanoparticles
Silica
title_short Fe3O4-SiO2 mesoporous core/shell nanoparticles for magnetic field-induced ibuprofen-controlled release
title_full Fe3O4-SiO2 mesoporous core/shell nanoparticles for magnetic field-induced ibuprofen-controlled release
title_fullStr Fe3O4-SiO2 mesoporous core/shell nanoparticles for magnetic field-induced ibuprofen-controlled release
title_full_unstemmed Fe3O4-SiO2 mesoporous core/shell nanoparticles for magnetic field-induced ibuprofen-controlled release
title_sort Fe3O4-SiO2 mesoporous core/shell nanoparticles for magnetic field-induced ibuprofen-controlled release
dc.creator.none.fl_str_mv García Rodríguez, Lucía
Garayo Urabayen, Eneko
López Ortega, Alberto
Galarreta Rodríguez, Itziar
Cervera Gabalda, Laura María
Cruz Quesada, Guillermo
Cornejo Ibergallartu, Alfonso
Garrido Segovia, Julián José
Gómez Polo, Cristina
Pérez de Landazábal Berganzo, José Ignacio
author García Rodríguez, Lucía
author_facet García Rodríguez, Lucía
Garayo Urabayen, Eneko
López Ortega, Alberto
Galarreta Rodríguez, Itziar
Cervera Gabalda, Laura María
Cruz Quesada, Guillermo
Cornejo Ibergallartu, Alfonso
Garrido Segovia, Julián José
Gómez Polo, Cristina
Pérez de Landazábal Berganzo, José Ignacio
author_role author
author2 Garayo Urabayen, Eneko
López Ortega, Alberto
Galarreta Rodríguez, Itziar
Cervera Gabalda, Laura María
Cruz Quesada, Guillermo
Cornejo Ibergallartu, Alfonso
Garrido Segovia, Julián José
Gómez Polo, Cristina
Pérez de Landazábal Berganzo, José Ignacio
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ciencias
Zientziak
Institute for Advanced Materials and Mathematics - INAMAT2
Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa, PJUPNA2020
Gobierno de Navarra / Nafarroako Gobernua
dc.subject.none.fl_str_mv Drug release
Hyperthermia
Magnetic properties
Nanoparticles
Silica
topic Drug release
Hyperthermia
Magnetic properties
Nanoparticles
Silica
description Hybrid magnetic nanoparticles made up of an iron oxide, Fe3O4, core and a mesoporous SiO2 shell with high magnetization and a large surface area were proposed as an efficient drug delivery platform. The core/shell structure was synthesized by two seed-mediated growth steps combining solvothermal and sol—gel approaches and using organic molecules as a porous scaffolding template. The system presents a mean particle diameter of 30(5) nm (9 nm magnetic core diameter and 10 nm silica shell thickness) with superparamagnetic behavior, saturation magnetization of 32 emu/g, and a significant AC magnetic-field-induced heating response (SAR = 63 W/gFe3O4, measured at an amplitude of 400 Oe and a frequency of 307 kHz). Using ibuprofen as a model drug, the specific surface area (231 m2/g) of the porous structure exhibits a high molecule loading capacity (10 wt %), and controlled drug release efficiency (67%) can be achieved using the external AC magnetic field for short time periods (5 min), showing faster and higher drug desorption compared to that of similar stimulus-responsive iron oxide-based nanocarriers. In addition, it is demonstrated that the magnetic field-induced drug release shows higher efficiency compared to that of the sustained release at fixed temperatures (47 and 53% for 37 and 42 °C, respectively), considering that the maximum temperature reached during the exposure to the magnetic field is well below (31 °C). Therefore, it can be hypothesized that short periods of exposure to the oscillating field induce much greater heating within the nanoparticles than in the external solution.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/53095
url https://hdl.handle.net/2454/53095
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113558RB-C42
info:eu-repo/grantAgreement/AEI/RED2018-555102626-T/
dc.rights.none.fl_str_mv © 2022 American Chemical Society.
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © 2022 American Chemical Society.
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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