Maternal prenatal nut and seafood consumption and child neuropsychological function from 4 to 15 years of age: a population-based cohort study.

BACKGROUND: Understanding the role of maternal diet in early brain development is critical, as pregnancy represents a period of significant vulnerability and growth for the developing brain. OBJECTIVES: This study aims to assess the association between maternal nuts, total seafood, and large fatty f...

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Autores: Pinar-Martí A, Ayala-Aldana N, Ruiz-Rivera M, Lertxundi N, Subiza-Pérez M, González-Safont L, Vioque J, Riaño-Galán I, Rodríguez-Dehli C, Iglesias-Vázquez L, Arija V, Fernández-Barrés S, Romaguera D, Pascual-Rubio V, Fabregat-Sanjuan A, Healy D, Basagaña X, Vrijheid M, Guxens M, Foraster M, Julvez J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:dnet:isabial_____::e29c997cfb6ef555f2b7bee721fe1fed
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones12661
https://www.sciencedirect.com/science/article/pii/S0002916525002497?pes=vor&utm_source=clarivate&getft_integrator=clarivate
Access Level:acceso abierto
Palabra clave:maternal diet
neuropsychological development
nuts and seafood
omega-3 fatty acids
pregnancy
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spelling Maternal prenatal nut and seafood consumption and child neuropsychological function from 4 to 15 years of age: a population-based cohort study.Pinar-Martí AAyala-Aldana NRuiz-Rivera MLertxundi NSubiza-Pérez MGonzález-Safont LVioque JRiaño-Galán IRodríguez-Dehli CIglesias-Vázquez LArija VFernández-Barrés SRomaguera DPascual-Rubio VFabregat-Sanjuan AHealy DBasagaña XVrijheid MGuxens MForaster MJulvez Jmaternal dietneuropsychological developmentnuts and seafoodomega-3 fatty acidspregnancyBACKGROUND: Understanding the role of maternal diet in early brain development is critical, as pregnancy represents a period of significant vulnerability and growth for the developing brain. OBJECTIVES: This study aims to assess the association between maternal nuts, total seafood, and large fatty fish consumption during pregnancy and offspring neuropsychological function =15 y, considering the potential mediation of omega-3 fatty acids. METHODS: This study was part of The Spanish Childhood and Environment birth cohort, following 1737 mother-child pairs from pregnancy to age 15. Maternal diet was evaluated using a semiquantitative food frequency questionnaire, whereas children's neuropsychological function was measured through standardized computer-based tests. Attention (hit reaction time and its variability, HRT and HRT-SE) was measured with the Conners' Kiddie Continuous Performance Test and the Attention Network Test. Working memory (detectability in 2-back, d2', and 3-back tasks, d3') was evaluated using the N-back task. Fluid intelligence was assessed with Raven's Progressive Matrices and the Test of Primary Mental Abilities. Linear mixed-effects regression models assessed the association of nuts, seafood and large fatty fish with neuropsychological outcomes, whereas generalized structural equation modeling was used for mediation analyses. RESULTS: Higher maternal nut consumption was significantly linked to improved attention [HRT-SE ß = -0.05, 95% confidence interval (CI): -0.09, -0.00] and working memory (d2' ß = 0.05, 95% CI: 0.00, 0.09, and d3' ß = 0.06, 95% CI: 0.02, 0.11) in offspring. Greater consumption of large fatty fish was associated with better attention (HRT-SE ß = -0.06, 95% CI: -0.10, -0.02; and HRT ß = -0.04, 95% CI: -0.08, -0.00), and fluid intelligence (ß = 0.08, 95% CI: 0.02, 0.13). Omega-3 fatty acids mediated 8%-14% of these effects on attention. CONCLUSIONS: Maternal diet at pregnancy and omega-3 intake may support long-term cognitive development in children and adolescents.ELSEVIER SCIENCE INC2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones12661https://www.sciencedirect.com/science/article/pii/S0002916525002497?pes=vor&utm_source=clarivate&getft_integrator=clarivateAMERICAN JOURNAL OF CLINICAL NUTRITIONISSN: 00029165ISSNe: 19383207reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:dnet:isabial_____::e29c997cfb6ef555f2b7bee721fe1fed2026-06-12T10:20:37Z
dc.title.none.fl_str_mv Maternal prenatal nut and seafood consumption and child neuropsychological function from 4 to 15 years of age: a population-based cohort study.
title Maternal prenatal nut and seafood consumption and child neuropsychological function from 4 to 15 years of age: a population-based cohort study.
spellingShingle Maternal prenatal nut and seafood consumption and child neuropsychological function from 4 to 15 years of age: a population-based cohort study.
Pinar-Martí A
maternal diet
neuropsychological development
nuts and seafood
omega-3 fatty acids
pregnancy
title_short Maternal prenatal nut and seafood consumption and child neuropsychological function from 4 to 15 years of age: a population-based cohort study.
title_full Maternal prenatal nut and seafood consumption and child neuropsychological function from 4 to 15 years of age: a population-based cohort study.
title_fullStr Maternal prenatal nut and seafood consumption and child neuropsychological function from 4 to 15 years of age: a population-based cohort study.
title_full_unstemmed Maternal prenatal nut and seafood consumption and child neuropsychological function from 4 to 15 years of age: a population-based cohort study.
title_sort Maternal prenatal nut and seafood consumption and child neuropsychological function from 4 to 15 years of age: a population-based cohort study.
dc.creator.none.fl_str_mv Pinar-Martí A
Ayala-Aldana N
Ruiz-Rivera M
Lertxundi N
Subiza-Pérez M
González-Safont L
Vioque J
Riaño-Galán I
Rodríguez-Dehli C
Iglesias-Vázquez L
Arija V
Fernández-Barrés S
Romaguera D
Pascual-Rubio V
Fabregat-Sanjuan A
Healy D
Basagaña X
Vrijheid M
Guxens M
Foraster M
Julvez J
author Pinar-Martí A
author_facet Pinar-Martí A
Ayala-Aldana N
Ruiz-Rivera M
Lertxundi N
Subiza-Pérez M
González-Safont L
Vioque J
Riaño-Galán I
Rodríguez-Dehli C
Iglesias-Vázquez L
Arija V
Fernández-Barrés S
Romaguera D
Pascual-Rubio V
Fabregat-Sanjuan A
Healy D
Basagaña X
Vrijheid M
Guxens M
Foraster M
Julvez J
author_role author
author2 Ayala-Aldana N
Ruiz-Rivera M
Lertxundi N
Subiza-Pérez M
González-Safont L
Vioque J
Riaño-Galán I
Rodríguez-Dehli C
Iglesias-Vázquez L
Arija V
Fernández-Barrés S
Romaguera D
Pascual-Rubio V
Fabregat-Sanjuan A
Healy D
Basagaña X
Vrijheid M
Guxens M
Foraster M
Julvez J
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv maternal diet
neuropsychological development
nuts and seafood
omega-3 fatty acids
pregnancy
topic maternal diet
neuropsychological development
nuts and seafood
omega-3 fatty acids
pregnancy
description BACKGROUND: Understanding the role of maternal diet in early brain development is critical, as pregnancy represents a period of significant vulnerability and growth for the developing brain. OBJECTIVES: This study aims to assess the association between maternal nuts, total seafood, and large fatty fish consumption during pregnancy and offspring neuropsychological function =15 y, considering the potential mediation of omega-3 fatty acids. METHODS: This study was part of The Spanish Childhood and Environment birth cohort, following 1737 mother-child pairs from pregnancy to age 15. Maternal diet was evaluated using a semiquantitative food frequency questionnaire, whereas children's neuropsychological function was measured through standardized computer-based tests. Attention (hit reaction time and its variability, HRT and HRT-SE) was measured with the Conners' Kiddie Continuous Performance Test and the Attention Network Test. Working memory (detectability in 2-back, d2', and 3-back tasks, d3') was evaluated using the N-back task. Fluid intelligence was assessed with Raven's Progressive Matrices and the Test of Primary Mental Abilities. Linear mixed-effects regression models assessed the association of nuts, seafood and large fatty fish with neuropsychological outcomes, whereas generalized structural equation modeling was used for mediation analyses. RESULTS: Higher maternal nut consumption was significantly linked to improved attention [HRT-SE ß = -0.05, 95% confidence interval (CI): -0.09, -0.00] and working memory (d2' ß = 0.05, 95% CI: 0.00, 0.09, and d3' ß = 0.06, 95% CI: 0.02, 0.11) in offspring. Greater consumption of large fatty fish was associated with better attention (HRT-SE ß = -0.06, 95% CI: -0.10, -0.02; and HRT ß = -0.04, 95% CI: -0.08, -0.00), and fluid intelligence (ß = 0.08, 95% CI: 0.02, 0.13). Omega-3 fatty acids mediated 8%-14% of these effects on attention. CONCLUSIONS: Maternal diet at pregnancy and omega-3 intake may support long-term cognitive development in children and adolescents.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones12661
https://www.sciencedirect.com/science/article/pii/S0002916525002497?pes=vor&utm_source=clarivate&getft_integrator=clarivate
url https://isabial.portalinvestigacion.com/publicaciones12661
https://www.sciencedirect.com/science/article/pii/S0002916525002497?pes=vor&utm_source=clarivate&getft_integrator=clarivate
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCIENCE INC
publisher.none.fl_str_mv ELSEVIER SCIENCE INC
dc.source.none.fl_str_mv AMERICAN JOURNAL OF CLINICAL NUTRITION
ISSN: 00029165
ISSNe: 19383207
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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