Cardiac and mitochondrial function in HIV-uninfected fetuses exposed to antiretroviral treatment

Podeu consultar les dades crues associades a aquest article a: http://hdl.handle.net/2445/128304 [recurs relacionat]

Detalles Bibliográficos
Autores: García-Otero, Laura, López, Marta, Guitart Mampel, Mariona, Morén Núñez, Constanza, Goncé Mellgren, Anna, Esteve, Carol, Salazar, Laura, Gómez, Olga, Martínez Crespo, Josep M. (Josep Maria), Torres Murillo, Berta, César Diaz, Sergio, Garrabou Tornos, Glòria, Crispi Brillas, Fàtima, Gratacós Solsona, Eduard
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/148934
Acceso en línea:https://hdl.handle.net/2445/148934
Access Level:acceso abierto
Palabra clave:Fetus
Antiretrovirals
VIH (Virus)
Antiretroviral agents
HIV (Viruses)
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spelling Cardiac and mitochondrial function in HIV-uninfected fetuses exposed to antiretroviral treatmentGarcía-Otero, LauraLópez, MartaGuitart Mampel, MarionaMorén Núñez, ConstanzaGoncé Mellgren, AnnaEsteve, CarolSalazar, LauraGómez, OlgaMartínez Crespo, Josep M. (Josep Maria)Torres Murillo, BertaCésar Diaz, SergioGarrabou Tornos, GlòriaCrispi Brillas, FàtimaGratacós Solsona, EduardFetusAntiretroviralsVIH (Virus)FetusAntiretroviral agentsHIV (Viruses)Podeu consultar les dades crues associades a aquest article a: http://hdl.handle.net/2445/128304 [recurs relacionat]BACKGROUND: Mitochondrial toxicity related to maternal combined antiretroviral treatment (cART) may have an impact on the heart of HIV-exposed uninfected (HEU) fetuses. Our objective was to evaluate fetal cardiovascular and mitochondrial biomarkers in HIV pregnancies. METHODS: Prospective cohort including 47 HIV-infected and 47 non HIV-infected pregnancies. Fetal echocardiography was performed at 26-32 weeks of pregnancy. Umbilical cord blood and placental tissue were collected to study mitochondrial DNA content (mtDNA) (ratio 12SrRNA/RNAseP) and mitochondrial function (cytochrome c oxidase, COX, enzymatic activity) normalized by mitochondrial content (citrate synthase, CS). RESULTS: HEU fetuses showed hypertrophic hearts (left myocardial wall thickness: HIV mean 3.21 mm (SD 0.81) vs. non-HIV 2.72 (0.42), p = 0.012), with signs of systolic and diastolic dysfunction (isovolumic relaxation time: HIV 52.2 ms (8.85) vs. non-HIV 42.5 ms (7.30); p<0.001). Cord blood mitochondrial content was significantly increased in HIV-exposed fetuses (CS activity: HIV 82.9 nmol/min.mg of protein (SD 40.5) vs. non-HIV 56.7 nmol/min.mg of protein (28.4); p = 0.007), with no differences in mtDNA content and COX activity. Both myocardial and mitochondrial mass parameters were significantly associated with zidovudine exposure. CONCLUSIONS: HEU fetuses showed signs of increased myocardial and mitochondrial mass associated with maternal zidovudine treatment, suggesting a fetal adaptive response to cART toxicity.Public Library of Science (PLoS)2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/148934Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0213279PLoS One, 2019, vol. 14, num. 3, p. e0213279https://doi.org/10.1371/journal.pone.0213279http://hdl.handle.net/2445/128304cc-by (c) García-Otero, Laura et al., 2019http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1489342026-05-27T06:46:51Z
dc.title.none.fl_str_mv Cardiac and mitochondrial function in HIV-uninfected fetuses exposed to antiretroviral treatment
title Cardiac and mitochondrial function in HIV-uninfected fetuses exposed to antiretroviral treatment
spellingShingle Cardiac and mitochondrial function in HIV-uninfected fetuses exposed to antiretroviral treatment
García-Otero, Laura
Fetus
Antiretrovirals
VIH (Virus)
Fetus
Antiretroviral agents
HIV (Viruses)
title_short Cardiac and mitochondrial function in HIV-uninfected fetuses exposed to antiretroviral treatment
title_full Cardiac and mitochondrial function in HIV-uninfected fetuses exposed to antiretroviral treatment
title_fullStr Cardiac and mitochondrial function in HIV-uninfected fetuses exposed to antiretroviral treatment
title_full_unstemmed Cardiac and mitochondrial function in HIV-uninfected fetuses exposed to antiretroviral treatment
title_sort Cardiac and mitochondrial function in HIV-uninfected fetuses exposed to antiretroviral treatment
dc.creator.none.fl_str_mv García-Otero, Laura
López, Marta
Guitart Mampel, Mariona
Morén Núñez, Constanza
Goncé Mellgren, Anna
Esteve, Carol
Salazar, Laura
Gómez, Olga
Martínez Crespo, Josep M. (Josep Maria)
Torres Murillo, Berta
César Diaz, Sergio
Garrabou Tornos, Glòria
Crispi Brillas, Fàtima
Gratacós Solsona, Eduard
author García-Otero, Laura
author_facet García-Otero, Laura
López, Marta
Guitart Mampel, Mariona
Morén Núñez, Constanza
Goncé Mellgren, Anna
Esteve, Carol
Salazar, Laura
Gómez, Olga
Martínez Crespo, Josep M. (Josep Maria)
Torres Murillo, Berta
César Diaz, Sergio
Garrabou Tornos, Glòria
Crispi Brillas, Fàtima
Gratacós Solsona, Eduard
author_role author
author2 López, Marta
Guitart Mampel, Mariona
Morén Núñez, Constanza
Goncé Mellgren, Anna
Esteve, Carol
Salazar, Laura
Gómez, Olga
Martínez Crespo, Josep M. (Josep Maria)
Torres Murillo, Berta
César Diaz, Sergio
Garrabou Tornos, Glòria
Crispi Brillas, Fàtima
Gratacós Solsona, Eduard
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Fetus
Antiretrovirals
VIH (Virus)
Fetus
Antiretroviral agents
HIV (Viruses)
topic Fetus
Antiretrovirals
VIH (Virus)
Fetus
Antiretroviral agents
HIV (Viruses)
description Podeu consultar les dades crues associades a aquest article a: http://hdl.handle.net/2445/128304 [recurs relacionat]
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/148934
url https://hdl.handle.net/2445/148934
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0213279
PLoS One, 2019, vol. 14, num. 3, p. e0213279
https://doi.org/10.1371/journal.pone.0213279
http://hdl.handle.net/2445/128304
dc.rights.none.fl_str_mv cc-by (c) García-Otero, Laura et al., 2019
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) García-Otero, Laura et al., 2019
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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