Early Holocene preservation differences between cortical and trabecular bone proteomes

Skeletal sample selection for evolutionary palaeoproteomic studies is currently based on the availability of material, without taking into account the influence of bone biology on the proteome composition of living bone. A prime example concerns the cortical and trabecular bone that is present simul...

Descripción completa

Detalles Bibliográficos
Autores: Ásmundsdóttir, Ragnheiður Diljá, Hansen, Jakob|||0000-0001-5795-1761, Fagernäs, Zandra, Troché, Gaudry, Olsen, Jesper, Saña Seguí, Maria|||0000-0002-8344-0639, Frido, Welker
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:309099
Acceso en línea:https://ddd.uab.cat/record/309099
https://dx.doi.org/urn:doi:10.1016/j.jasrep.2024.104643
Access Level:acceso abierto
Palabra clave:Palaeoproteomics
Skeletal remains
Osteogenesis
Bone turnover
Sampling ethics
Shotgun proteomics
ZooMS
id ES_fb4ef1bcffa3f8bd9ec349dc8a032938
oai_identifier_str oai:ddd.uab.cat:309099
network_acronym_str ES
network_name_str España
repository_id_str
spelling Early Holocene preservation differences between cortical and trabecular bone proteomesÁsmundsdóttir, Ragnheiður DiljáHansen, Jakob|||0000-0001-5795-1761Fagernäs, ZandraTroché, GaudryOlsen, JesperSaña Seguí, Maria|||0000-0002-8344-0639Frido, WelkerPalaeoproteomicsSkeletal remainsOsteogenesisBone turnoverSampling ethicsShotgun proteomicsZooMSSkeletal sample selection for evolutionary palaeoproteomic studies is currently based on the availability of material, without taking into account the influence of bone biology on the proteome composition of living bone. A prime example concerns the cortical and trabecular bone that is present simultaneously in many skeletal elements, including those recovered from archaeological sites. These two bone components are formed and maintained in different manners and at different rates. In palaeoproteomics there is currently no empirical data demonstrating differences in composition and/or preservation of cortical and trabecular bone proteomes. Here we analyse pairs of cortical and trabecular bone from six Early Holocene ungulate rib specimens from the site of La Draga, Spain, using shotgun proteomics. We observe generally larger proteomes, a larger number of peptides, and lower rates of degradation, for the cortical bone samples compared to the trabecular bone samples. These results suggest that in degraded proteomic contexts, preference should be given to the sampling of cortical bone in order to maximise the retrieval of larger and better-preserved bone proteomes. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/309099https://dx.doi.org/urn:doi:10.1016/j.jasrep.2024.104643reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3090992026-06-06T12:50:31Z
dc.title.none.fl_str_mv Early Holocene preservation differences between cortical and trabecular bone proteomes
title Early Holocene preservation differences between cortical and trabecular bone proteomes
spellingShingle Early Holocene preservation differences between cortical and trabecular bone proteomes
Ásmundsdóttir, Ragnheiður Diljá
Palaeoproteomics
Skeletal remains
Osteogenesis
Bone turnover
Sampling ethics
Shotgun proteomics
ZooMS
title_short Early Holocene preservation differences between cortical and trabecular bone proteomes
title_full Early Holocene preservation differences between cortical and trabecular bone proteomes
title_fullStr Early Holocene preservation differences between cortical and trabecular bone proteomes
title_full_unstemmed Early Holocene preservation differences between cortical and trabecular bone proteomes
title_sort Early Holocene preservation differences between cortical and trabecular bone proteomes
dc.creator.none.fl_str_mv Ásmundsdóttir, Ragnheiður Diljá
Hansen, Jakob|||0000-0001-5795-1761
Fagernäs, Zandra
Troché, Gaudry
Olsen, Jesper
Saña Seguí, Maria|||0000-0002-8344-0639
Frido, Welker
author Ásmundsdóttir, Ragnheiður Diljá
author_facet Ásmundsdóttir, Ragnheiður Diljá
Hansen, Jakob|||0000-0001-5795-1761
Fagernäs, Zandra
Troché, Gaudry
Olsen, Jesper
Saña Seguí, Maria|||0000-0002-8344-0639
Frido, Welker
author_role author
author2 Hansen, Jakob|||0000-0001-5795-1761
Fagernäs, Zandra
Troché, Gaudry
Olsen, Jesper
Saña Seguí, Maria|||0000-0002-8344-0639
Frido, Welker
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Palaeoproteomics
Skeletal remains
Osteogenesis
Bone turnover
Sampling ethics
Shotgun proteomics
ZooMS
topic Palaeoproteomics
Skeletal remains
Osteogenesis
Bone turnover
Sampling ethics
Shotgun proteomics
ZooMS
description Skeletal sample selection for evolutionary palaeoproteomic studies is currently based on the availability of material, without taking into account the influence of bone biology on the proteome composition of living bone. A prime example concerns the cortical and trabecular bone that is present simultaneously in many skeletal elements, including those recovered from archaeological sites. These two bone components are formed and maintained in different manners and at different rates. In palaeoproteomics there is currently no empirical data demonstrating differences in composition and/or preservation of cortical and trabecular bone proteomes. Here we analyse pairs of cortical and trabecular bone from six Early Holocene ungulate rib specimens from the site of La Draga, Spain, using shotgun proteomics. We observe generally larger proteomes, a larger number of peptides, and lower rates of degradation, for the cortical bone samples compared to the trabecular bone samples. These results suggest that in degraded proteomic contexts, preference should be given to the sampling of cortical bone in order to maximise the retrieval of larger and better-preserved bone proteomes.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/309099
https://dx.doi.org/urn:doi:10.1016/j.jasrep.2024.104643
url https://ddd.uab.cat/record/309099
https://dx.doi.org/urn:doi:10.1016/j.jasrep.2024.104643
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869425317466079232
score 15,811543

Similares en LA Referencia