The gut microbiota in persistent post-operative pain following breast cancer surgery

Persistent post-surgical pain (PPSP) is defined as pain which continues after a surgical operation in a significant form for at least three months (and is not related to pre-existing painful conditions). PPSP is a common, under-recognised, and important clinical problem which affects millions of pat...

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Autores: Masaud, Khaled, Collins, James M., Cabrera-Rubio, Raúl, Corrigan, Mark, Cotter, Paul D., O'Brien, Niall, Bluett, Ronan, Jimenez, Clare Keaveney, O'Mahony, Siobhain M., Shorten, George D
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/360779
Acesso em linha:http://hdl.handle.net/10261/360779
https://api.elsevier.com/content/abstract/scopus_id/85194862147
Access Level:acceso abierto
Palavra-chave:Gut microbiota
Surgery
Pain
microbiology
pain
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spelling The gut microbiota in persistent post-operative pain following breast cancer surgeryMasaud, KhaledCollins, James M.Cabrera-Rubio, RaúlCorrigan, MarkCotter, Paul D.O'Brien, NiallBluett, RonanJimenez, Clare KeaveneyO'Mahony, Siobhain M.Shorten, George DGut microbiotaSurgeryPainmicrobiologypainPersistent post-surgical pain (PPSP) is defined as pain which continues after a surgical operation in a significant form for at least three months (and is not related to pre-existing painful conditions). PPSP is a common, under-recognised, and important clinical problem which affects millions of patients worldwide. Preventative measures which are currently available include the selection of a minimally invasive surgical technique and an aggressive multimodal perioperative analgesic regimen. More recently, a role for the gut microbiota in pain modulation has become increasingly apparent. This study aims to investigate any relationship between the gut microbiota and PPSP. A prospective observational study of 68 female adult patients undergoing surgery for management of breast cancer was carried out. Stool samples from 45 of these patients were obtained to analyse the composition of the gut microbiota. Measures of pain and state-trait anxiety were also taken to investigate further dimensions in any relationship between the gut microbiota and PPSP. At 12 weeks postoperatively, 21 patients (51.2%) did not have any pain and 20 patients (48.8%) reported feeling pain that persisted at that time. Analysis of the gut microbiota revealed significantly lower alpha diversity (using three measures) in those patients reporting severe pain at the 60 min post-operative and the 12 weeks post-operative timepoints. A cluster of taxa represented by Bifidobacterium longum, and Faecalibacterium prausnitzii was closely associated with those individuals reporting no pain at 12 weeks postoperatively, while Megamonas hypermegale, Bacteroides pectinophilus, Ruminococcus bromii, and Roseburia hominis clustered relatively closely in the group of patients fulfilling the criteria for persistent post-operative pain. We report for the first time specific associations between the gut microbiota composition and the presence or absence of PPSP. This may provide further insights into mechanisms behind the role of the gut microbiota in the development of PPSP and could inform future treatment strategies.APC Microbiome Ireland is a research centre funded by Science Foundation Ireland through the Irish Government's National Development Plan (Grant Number SFI/12/RC/2273_P2).Peer reviewedSpringer NatureScience Foundation IrelandCabrera Rubio, Raul [0000-0003-3652-9558]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/360779https://api.elsevier.com/content/abstract/scopus_id/85194862147reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésScientific reportsThe underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1038/s41598-024-62397-1https://doi.org/10.1038/s41598-024-62397-1Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3607792026-05-22T06:33:51Z
dc.title.none.fl_str_mv The gut microbiota in persistent post-operative pain following breast cancer surgery
title The gut microbiota in persistent post-operative pain following breast cancer surgery
spellingShingle The gut microbiota in persistent post-operative pain following breast cancer surgery
Masaud, Khaled
Gut microbiota
Surgery
Pain
microbiology
pain
title_short The gut microbiota in persistent post-operative pain following breast cancer surgery
title_full The gut microbiota in persistent post-operative pain following breast cancer surgery
title_fullStr The gut microbiota in persistent post-operative pain following breast cancer surgery
title_full_unstemmed The gut microbiota in persistent post-operative pain following breast cancer surgery
title_sort The gut microbiota in persistent post-operative pain following breast cancer surgery
dc.creator.none.fl_str_mv Masaud, Khaled
Collins, James M.
Cabrera-Rubio, Raúl
Corrigan, Mark
Cotter, Paul D.
O'Brien, Niall
Bluett, Ronan
Jimenez, Clare Keaveney
O'Mahony, Siobhain M.
Shorten, George D
author Masaud, Khaled
author_facet Masaud, Khaled
Collins, James M.
Cabrera-Rubio, Raúl
Corrigan, Mark
Cotter, Paul D.
O'Brien, Niall
Bluett, Ronan
Jimenez, Clare Keaveney
O'Mahony, Siobhain M.
Shorten, George D
author_role author
author2 Collins, James M.
Cabrera-Rubio, Raúl
Corrigan, Mark
Cotter, Paul D.
O'Brien, Niall
Bluett, Ronan
Jimenez, Clare Keaveney
O'Mahony, Siobhain M.
Shorten, George D
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Science Foundation Ireland
Cabrera Rubio, Raul [0000-0003-3652-9558]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Gut microbiota
Surgery
Pain
microbiology
pain
topic Gut microbiota
Surgery
Pain
microbiology
pain
description Persistent post-surgical pain (PPSP) is defined as pain which continues after a surgical operation in a significant form for at least three months (and is not related to pre-existing painful conditions). PPSP is a common, under-recognised, and important clinical problem which affects millions of patients worldwide. Preventative measures which are currently available include the selection of a minimally invasive surgical technique and an aggressive multimodal perioperative analgesic regimen. More recently, a role for the gut microbiota in pain modulation has become increasingly apparent. This study aims to investigate any relationship between the gut microbiota and PPSP. A prospective observational study of 68 female adult patients undergoing surgery for management of breast cancer was carried out. Stool samples from 45 of these patients were obtained to analyse the composition of the gut microbiota. Measures of pain and state-trait anxiety were also taken to investigate further dimensions in any relationship between the gut microbiota and PPSP. At 12 weeks postoperatively, 21 patients (51.2%) did not have any pain and 20 patients (48.8%) reported feeling pain that persisted at that time. Analysis of the gut microbiota revealed significantly lower alpha diversity (using three measures) in those patients reporting severe pain at the 60 min post-operative and the 12 weeks post-operative timepoints. A cluster of taxa represented by Bifidobacterium longum, and Faecalibacterium prausnitzii was closely associated with those individuals reporting no pain at 12 weeks postoperatively, while Megamonas hypermegale, Bacteroides pectinophilus, Ruminococcus bromii, and Roseburia hominis clustered relatively closely in the group of patients fulfilling the criteria for persistent post-operative pain. We report for the first time specific associations between the gut microbiota composition and the presence or absence of PPSP. This may provide further insights into mechanisms behind the role of the gut microbiota in the development of PPSP and could inform future treatment strategies.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/360779
https://api.elsevier.com/content/abstract/scopus_id/85194862147
url http://hdl.handle.net/10261/360779
https://api.elsevier.com/content/abstract/scopus_id/85194862147
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Scientific reports
The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1038/s41598-024-62397-1
https://doi.org/10.1038/s41598-024-62397-1
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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