Characterization of Monoclonal Gammopathy of Undetermined Significance by Calorimetric Analysis of Blood Serum Proteome
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant proliferative disorder that may progress to multiple myeloma, a malignant plasma cell neoplasia. We evaluated differential scanning calorimetry (DSC) as an experimental tool for differentiating serum samples of MGUS patients...
| Autores: | , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Conselleria de Salut i Consum del Govern de les Illes Balears |
| Repositorio: | Docusalut |
| Idioma: | inglés |
| OAI Identifier: | oai:docusalut.com:20.500.13003/10906 |
| Acceso en línea: | https://hdl.handle.net/20.500.13003/10906 |
| Access Level: | acceso abierto |
| Palabra clave: | Diagnosis, Differential Calorimetry, Differential Scanning Monoclonal Gammopathy of Undetermined Significance Humans Adult Young Adult Case-Control Studies Middle Aged Blood Proteins Aged Aged, 80 and over Proteome Proteomics Male Female Proteoma Diagnóstico Diferencial Proteínas Sanguíneas Anciano de 80 o más Años Proteómica Gammopatía Monoclonal de Relevancia Indeterminada Adulto Joven Anciano Persona de Mediana Edad Humanos Masculino Rastreo Diferencial de Calorimetría Femenino Estudios de Casos y Controles Adulto |
| Sumario: | Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant proliferative disorder that may progress to multiple myeloma, a malignant plasma cell neoplasia. We evaluated differential scanning calorimetry (DSC) as an experimental tool for differentiating serum samples of MGUS patients from healthy individuals. DSC thermograms can be used for monitoring changes in the serum proteome associated with MGUS. MGUS patients showed great variability in serum thermogram characteristics, which depended on the IgG, IgA or IgM iso-types and/or the. or. light chains. Thermogram feature parameters distinguished patients with MGUS from healthy people. Serum samples, named as non-MGUS, were also collected from patients with subjacent immunological pathologies who were discarded of having MGUS through serum immunofixation. They were used to verify the sensitivity of DSC for discriminating MGUS from related blood dyscrasias. Only some DSC thermogram feature parameters differentiated, to a lesser extent, between MGUS and non-MGUS individuals. We contemplate DSC as a tool for early diagnosis and monitoring of MGUS. |
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