Ionic coupling of hyaluronic acid with ethyl N-lauroyl L-arginate (LAE): Structure, properties and biocide activity of complexes

Ethyl alpha-N-lauroyl L-arginate hydrochloride (LAE) was coupled with hyaluronic acid (HyA) 2 to form ionic complexes with LAE to HyA ratios of 1:1 and 1:2. The complexes were extensively 3 characterized by FTIR and NMR spectroscopies and their thermal properties evaluated by 4 thermogravimetry and...

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Autores: Gamarra Montes, Ana|||0000-0002-7163-716X, Missagia, Beatriz, Urpí Garriga, Lourdes|||0000-0002-2356-033X, Morató Farreras, Jordi|||0000-0003-2588-8846, Muñoz Guerra, Sebastián|||0000-0002-4273-2301
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/122201
Acceso en línea:https://hdl.handle.net/2117/122201
https://dx.doi.org/10.1016/j.carbpol.2018.05.057
Access Level:acceso abierto
Palabra clave:Antimicrobial polymers
Ethyl alpha-N-lauroyl L-arginate
LAE
hyaluronic acid
ionic complexes
biocide activity
Biopolímers
Àrees temàtiques de la UPC::Enginyeria química
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oai_identifier_str oai:upcommons.upc.edu:2117/122201
network_acronym_str ES
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repository_id_str
spelling Ionic coupling of hyaluronic acid with ethyl N-lauroyl L-arginate (LAE): Structure, properties and biocide activity of complexesGamarra Montes, Ana|||0000-0002-7163-716XMissagia, BeatrizUrpí Garriga, Lourdes|||0000-0002-2356-033XMorató Farreras, Jordi|||0000-0003-2588-8846Muñoz Guerra, Sebastián|||0000-0002-4273-2301Antimicrobial polymersEthyl alpha-N-lauroyl L-arginateLAEhyaluronic acidionic complexesbiocide activityBiopolímersÀrees temàtiques de la UPC::Enginyeria químicaEthyl alpha-N-lauroyl L-arginate hydrochloride (LAE) was coupled with hyaluronic acid (HyA) 2 to form ionic complexes with LAE to HyA ratios of 1:1 and 1:2. The complexes were extensively 3 characterized by FTIR and NMR spectroscopies and their thermal properties evaluated by 4 thermogravimetry and calorimetry. Thin films prepared from these complexes by casting 5 displayed a smectic-like structure based on an ordered arrangement of LAE and HyA layers 6 with a nanometric periodicity of 3.8-3.9 nm. Films immersed in water at pH 7.4 and 5.5 7 dissociated to deliver free LAE to the environment and reaching the equilibrium in few hours. 8 The biocide activity of these films against both Gram-positive and Gram-negative bacteria was 9 preliminary assessed by the liquid medium method, and shown to be notable in both cases. The 10 antibacterial property of the complexes was found to increase with the content of LAE and to be 11 particularly efficient against Gram-negative S. enterica bacteria.Peer Reviewed20182018-10-0120182018-10-11journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/122201https://dx.doi.org/10.1016/j.carbpol.2018.05.057reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivs 3.0 Spainhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/1222012026-05-27T15:37:01Z
dc.title.none.fl_str_mv Ionic coupling of hyaluronic acid with ethyl N-lauroyl L-arginate (LAE): Structure, properties and biocide activity of complexes
title Ionic coupling of hyaluronic acid with ethyl N-lauroyl L-arginate (LAE): Structure, properties and biocide activity of complexes
spellingShingle Ionic coupling of hyaluronic acid with ethyl N-lauroyl L-arginate (LAE): Structure, properties and biocide activity of complexes
Gamarra Montes, Ana|||0000-0002-7163-716X
Antimicrobial polymers
Ethyl alpha-N-lauroyl L-arginate
LAE
hyaluronic acid
ionic complexes
biocide activity
Biopolímers
Àrees temàtiques de la UPC::Enginyeria química
title_short Ionic coupling of hyaluronic acid with ethyl N-lauroyl L-arginate (LAE): Structure, properties and biocide activity of complexes
title_full Ionic coupling of hyaluronic acid with ethyl N-lauroyl L-arginate (LAE): Structure, properties and biocide activity of complexes
title_fullStr Ionic coupling of hyaluronic acid with ethyl N-lauroyl L-arginate (LAE): Structure, properties and biocide activity of complexes
title_full_unstemmed Ionic coupling of hyaluronic acid with ethyl N-lauroyl L-arginate (LAE): Structure, properties and biocide activity of complexes
title_sort Ionic coupling of hyaluronic acid with ethyl N-lauroyl L-arginate (LAE): Structure, properties and biocide activity of complexes
dc.creator.none.fl_str_mv Gamarra Montes, Ana|||0000-0002-7163-716X
Missagia, Beatriz
Urpí Garriga, Lourdes|||0000-0002-2356-033X
Morató Farreras, Jordi|||0000-0003-2588-8846
Muñoz Guerra, Sebastián|||0000-0002-4273-2301
author Gamarra Montes, Ana|||0000-0002-7163-716X
author_facet Gamarra Montes, Ana|||0000-0002-7163-716X
Missagia, Beatriz
Urpí Garriga, Lourdes|||0000-0002-2356-033X
Morató Farreras, Jordi|||0000-0003-2588-8846
Muñoz Guerra, Sebastián|||0000-0002-4273-2301
author_role author
author2 Missagia, Beatriz
Urpí Garriga, Lourdes|||0000-0002-2356-033X
Morató Farreras, Jordi|||0000-0003-2588-8846
Muñoz Guerra, Sebastián|||0000-0002-4273-2301
author2_role author
author
author
author
dc.subject.none.fl_str_mv Antimicrobial polymers
Ethyl alpha-N-lauroyl L-arginate
LAE
hyaluronic acid
ionic complexes
biocide activity
Biopolímers
Àrees temàtiques de la UPC::Enginyeria química
topic Antimicrobial polymers
Ethyl alpha-N-lauroyl L-arginate
LAE
hyaluronic acid
ionic complexes
biocide activity
Biopolímers
Àrees temàtiques de la UPC::Enginyeria química
description Ethyl alpha-N-lauroyl L-arginate hydrochloride (LAE) was coupled with hyaluronic acid (HyA) 2 to form ionic complexes with LAE to HyA ratios of 1:1 and 1:2. The complexes were extensively 3 characterized by FTIR and NMR spectroscopies and their thermal properties evaluated by 4 thermogravimetry and calorimetry. Thin films prepared from these complexes by casting 5 displayed a smectic-like structure based on an ordered arrangement of LAE and HyA layers 6 with a nanometric periodicity of 3.8-3.9 nm. Films immersed in water at pH 7.4 and 5.5 7 dissociated to deliver free LAE to the environment and reaching the equilibrium in few hours. 8 The biocide activity of these films against both Gram-positive and Gram-negative bacteria was 9 preliminary assessed by the liquid medium method, and shown to be notable in both cases. The 10 antibacterial property of the complexes was found to increase with the content of LAE and to be 11 particularly efficient against Gram-negative S. enterica bacteria.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-10-01
2018
2018-10-11
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/122201
https://dx.doi.org/10.1016/j.carbpol.2018.05.057
url https://hdl.handle.net/2117/122201
https://dx.doi.org/10.1016/j.carbpol.2018.05.057
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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