Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells

Hepworth, M.R. (Matthew R.)|||/items/d26a7097-e211-40ea-ae49-5bd3ab177258; Fung, T.C. (Thomas C.)|||/items/98f132f8-9aae-4975-8858-b07fcfc2c83c; Masur, S.H. (Samuel H.)|||/items/adabd8e3-9c7d-46d3-8481-4da6f72274a3; Kelsen, J.R. (Judith R.)|||/items/7f3240e9-70b3-43eb-8650-ed5b35fbe9b9; McConnell, F.M. (Fiona M.)|||/items/fed04978-7aa6-4f89-997b-a91210c7357a; Dubrot-Armendáriz, J. (Juan)|||/items/b42afe78-7095-4682-8c2c-0904580d8d53; Withers, D.R. (David R.)|||/items/bc11d665-6985-4816-bba2-23e11f012b1a; Hugues, S. (Stéphanie)|||/items/437178cd-54c9-41db-b5c9-fa25dea04152; Farrar, M.A. (Michael A.)|||/items/92344920-933a-47db-bd11-2e294b939098; Reith, W. (Walter)|||/items/ddc6cd9b-c893-4e92-ac21-46e826cefea7; Eberl, G. (Gérard)|||/items/80c51a70-6a14-489f-bdeb-b20589e8c668; Baldassano, R.N. (Robert N.)|||/items/ff0277d8-6c56-4331-96af-d03fd0b609df; Laufer, T.M. (Terri M.)|||/items/02c4c567-90e3-4342-b237-ba8aef32651e; Elson, C.O. (Charles O.)|||/items/0925d979-3f74-4db5-b124-5960e68306de; Sonnenberg, G.F. (Gregory F.)|||/items/9ca16894-b394-44dd-87a3-3279d9ab0c44

Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells

Inflammatory CD4(+) T cell responses to self or commensal bacteria underlie the pathogenesis of autoimmunity and inflammatory bowel disease (IBD), respectively. Although selection of self-specific T cells in the thymus limits responses to mammalian tissue antigens, the mechanisms that control select...

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Autores:	Hepworth, M.R. (Matthew R.)\|\|\|/items/d26a7097-e211-40ea-ae49-5bd3ab177258, Fung, T.C. (Thomas C.)\|\|\|/items/98f132f8-9aae-4975-8858-b07fcfc2c83c, Masur, S.H. (Samuel H.)\|\|\|/items/adabd8e3-9c7d-46d3-8481-4da6f72274a3, Kelsen, J.R. (Judith R.)\|\|\|/items/7f3240e9-70b3-43eb-8650-ed5b35fbe9b9, McConnell, F.M. (Fiona M.)\|\|\|/items/fed04978-7aa6-4f89-997b-a91210c7357a, Dubrot-Armendáriz, J. (Juan)\|\|\|/items/b42afe78-7095-4682-8c2c-0904580d8d53, Withers, D.R. (David R.)\|\|\|/items/bc11d665-6985-4816-bba2-23e11f012b1a, Hugues, S. (Stéphanie)\|\|\|/items/437178cd-54c9-41db-b5c9-fa25dea04152, Farrar, M.A. (Michael A.)\|\|\|/items/92344920-933a-47db-bd11-2e294b939098, Reith, W. (Walter)\|\|\|/items/ddc6cd9b-c893-4e92-ac21-46e826cefea7, Eberl, G. (Gérard)\|\|\|/items/80c51a70-6a14-489f-bdeb-b20589e8c668, Baldassano, R.N. (Robert N.)\|\|\|/items/ff0277d8-6c56-4331-96af-d03fd0b609df, Laufer, T.M. (Terri M.)\|\|\|/items/02c4c567-90e3-4342-b237-ba8aef32651e, Elson, C.O. (Charles O.)\|\|\|/items/0925d979-3f74-4db5-b124-5960e68306de, Sonnenberg, G.F. (Gregory F.)\|\|\|/items/9ca16894-b394-44dd-87a3-3279d9ab0c44
Tipo de recurso:	artículo
Fecha de publicación:	2015
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/122667
Acceso en línea:	https://hdl.handle.net/10171/122667
Access Level:	acceso abierto
Palabra clave:	Commensal bacteria T cell selection Innate lymphoid cells Inflammatory bowel disease

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spelling	Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cellsHepworth, M.R. (Matthew R.)\|\|\|/items/d26a7097-e211-40ea-ae49-5bd3ab177258Fung, T.C. (Thomas C.)\|\|\|/items/98f132f8-9aae-4975-8858-b07fcfc2c83cMasur, S.H. (Samuel H.)\|\|\|/items/adabd8e3-9c7d-46d3-8481-4da6f72274a3Kelsen, J.R. (Judith R.)\|\|\|/items/7f3240e9-70b3-43eb-8650-ed5b35fbe9b9McConnell, F.M. (Fiona M.)\|\|\|/items/fed04978-7aa6-4f89-997b-a91210c7357aDubrot-Armendáriz, J. (Juan)\|\|\|/items/b42afe78-7095-4682-8c2c-0904580d8d53Withers, D.R. (David R.)\|\|\|/items/bc11d665-6985-4816-bba2-23e11f012b1aHugues, S. (Stéphanie)\|\|\|/items/437178cd-54c9-41db-b5c9-fa25dea04152Farrar, M.A. (Michael A.)\|\|\|/items/92344920-933a-47db-bd11-2e294b939098Reith, W. (Walter)\|\|\|/items/ddc6cd9b-c893-4e92-ac21-46e826cefea7Eberl, G. (Gérard)\|\|\|/items/80c51a70-6a14-489f-bdeb-b20589e8c668Baldassano, R.N. (Robert N.)\|\|\|/items/ff0277d8-6c56-4331-96af-d03fd0b609dfLaufer, T.M. (Terri M.)\|\|\|/items/02c4c567-90e3-4342-b237-ba8aef32651eElson, C.O. (Charles O.)\|\|\|/items/0925d979-3f74-4db5-b124-5960e68306deSonnenberg, G.F. (Gregory F.)\|\|\|/items/9ca16894-b394-44dd-87a3-3279d9ab0c44Commensal bacteriaT cell selectionInnate lymphoid cellsInflammatory bowel diseaseInflammatory CD4(+) T cell responses to self or commensal bacteria underlie the pathogenesis of autoimmunity and inflammatory bowel disease (IBD), respectively. Although selection of self-specific T cells in the thymus limits responses to mammalian tissue antigens, the mechanisms that control selection of commensal bacteria-specific T cells remain poorly understood. Here, we demonstrate that group 3 innate lymphoid cell (ILC3)-intrinsic expression of major histocompatibility complex class II (MHCII) is regulated similarly to thymic epithelial cells and that MHCII(+) ILC3s directly induce cell death of activated commensal bacteria-specific T cells. Further, MHCII on colonic ILC3s was reduced in pediatric IBD patients. Collectively, these results define a selection pathway for commensal bacteria-specific CD4(+) T cells in the intestine and suggest that this process is dysregulated in human IBD.American Association for the Advancement of ScienceDadun. Depósito Académico Digital Universidad de Navarra20152015-01-0120152015-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/122667reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1226672026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells
title	Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells
spellingShingle	Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells Hepworth, M.R. (Matthew R.)\|\|\|/items/d26a7097-e211-40ea-ae49-5bd3ab177258 Commensal bacteria T cell selection Innate lymphoid cells Inflammatory bowel disease
title_short	Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells
title_full	Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells
title_fullStr	Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells
title_full_unstemmed	Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells
title_sort	Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells
dc.creator.none.fl_str_mv	Hepworth, M.R. (Matthew R.)\|\|\|/items/d26a7097-e211-40ea-ae49-5bd3ab177258 Fung, T.C. (Thomas C.)\|\|\|/items/98f132f8-9aae-4975-8858-b07fcfc2c83c Masur, S.H. (Samuel H.)\|\|\|/items/adabd8e3-9c7d-46d3-8481-4da6f72274a3 Kelsen, J.R. (Judith R.)\|\|\|/items/7f3240e9-70b3-43eb-8650-ed5b35fbe9b9 McConnell, F.M. (Fiona M.)\|\|\|/items/fed04978-7aa6-4f89-997b-a91210c7357a Dubrot-Armendáriz, J. (Juan)\|\|\|/items/b42afe78-7095-4682-8c2c-0904580d8d53 Withers, D.R. (David R.)\|\|\|/items/bc11d665-6985-4816-bba2-23e11f012b1a Hugues, S. (Stéphanie)\|\|\|/items/437178cd-54c9-41db-b5c9-fa25dea04152 Farrar, M.A. (Michael A.)\|\|\|/items/92344920-933a-47db-bd11-2e294b939098 Reith, W. (Walter)\|\|\|/items/ddc6cd9b-c893-4e92-ac21-46e826cefea7 Eberl, G. (Gérard)\|\|\|/items/80c51a70-6a14-489f-bdeb-b20589e8c668 Baldassano, R.N. (Robert N.)\|\|\|/items/ff0277d8-6c56-4331-96af-d03fd0b609df Laufer, T.M. (Terri M.)\|\|\|/items/02c4c567-90e3-4342-b237-ba8aef32651e Elson, C.O. (Charles O.)\|\|\|/items/0925d979-3f74-4db5-b124-5960e68306de Sonnenberg, G.F. (Gregory F.)\|\|\|/items/9ca16894-b394-44dd-87a3-3279d9ab0c44
author	Hepworth, M.R. (Matthew R.)\|\|\|/items/d26a7097-e211-40ea-ae49-5bd3ab177258
author_facet	Hepworth, M.R. (Matthew R.)\|\|\|/items/d26a7097-e211-40ea-ae49-5bd3ab177258 Fung, T.C. (Thomas C.)\|\|\|/items/98f132f8-9aae-4975-8858-b07fcfc2c83c Masur, S.H. (Samuel H.)\|\|\|/items/adabd8e3-9c7d-46d3-8481-4da6f72274a3 Kelsen, J.R. (Judith R.)\|\|\|/items/7f3240e9-70b3-43eb-8650-ed5b35fbe9b9 McConnell, F.M. (Fiona M.)\|\|\|/items/fed04978-7aa6-4f89-997b-a91210c7357a Dubrot-Armendáriz, J. (Juan)\|\|\|/items/b42afe78-7095-4682-8c2c-0904580d8d53 Withers, D.R. (David R.)\|\|\|/items/bc11d665-6985-4816-bba2-23e11f012b1a Hugues, S. (Stéphanie)\|\|\|/items/437178cd-54c9-41db-b5c9-fa25dea04152 Farrar, M.A. (Michael A.)\|\|\|/items/92344920-933a-47db-bd11-2e294b939098 Reith, W. (Walter)\|\|\|/items/ddc6cd9b-c893-4e92-ac21-46e826cefea7 Eberl, G. (Gérard)\|\|\|/items/80c51a70-6a14-489f-bdeb-b20589e8c668 Baldassano, R.N. (Robert N.)\|\|\|/items/ff0277d8-6c56-4331-96af-d03fd0b609df Laufer, T.M. (Terri M.)\|\|\|/items/02c4c567-90e3-4342-b237-ba8aef32651e Elson, C.O. (Charles O.)\|\|\|/items/0925d979-3f74-4db5-b124-5960e68306de Sonnenberg, G.F. (Gregory F.)\|\|\|/items/9ca16894-b394-44dd-87a3-3279d9ab0c44
author_role	author
author2	Fung, T.C. (Thomas C.)\|\|\|/items/98f132f8-9aae-4975-8858-b07fcfc2c83c Masur, S.H. (Samuel H.)\|\|\|/items/adabd8e3-9c7d-46d3-8481-4da6f72274a3 Kelsen, J.R. (Judith R.)\|\|\|/items/7f3240e9-70b3-43eb-8650-ed5b35fbe9b9 McConnell, F.M. (Fiona M.)\|\|\|/items/fed04978-7aa6-4f89-997b-a91210c7357a Dubrot-Armendáriz, J. (Juan)\|\|\|/items/b42afe78-7095-4682-8c2c-0904580d8d53 Withers, D.R. (David R.)\|\|\|/items/bc11d665-6985-4816-bba2-23e11f012b1a Hugues, S. (Stéphanie)\|\|\|/items/437178cd-54c9-41db-b5c9-fa25dea04152 Farrar, M.A. (Michael A.)\|\|\|/items/92344920-933a-47db-bd11-2e294b939098 Reith, W. (Walter)\|\|\|/items/ddc6cd9b-c893-4e92-ac21-46e826cefea7 Eberl, G. (Gérard)\|\|\|/items/80c51a70-6a14-489f-bdeb-b20589e8c668 Baldassano, R.N. (Robert N.)\|\|\|/items/ff0277d8-6c56-4331-96af-d03fd0b609df Laufer, T.M. (Terri M.)\|\|\|/items/02c4c567-90e3-4342-b237-ba8aef32651e Elson, C.O. (Charles O.)\|\|\|/items/0925d979-3f74-4db5-b124-5960e68306de Sonnenberg, G.F. (Gregory F.)\|\|\|/items/9ca16894-b394-44dd-87a3-3279d9ab0c44
author2_role	author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Commensal bacteria T cell selection Innate lymphoid cells Inflammatory bowel disease
topic	Commensal bacteria T cell selection Innate lymphoid cells Inflammatory bowel disease
description	Inflammatory CD4(+) T cell responses to self or commensal bacteria underlie the pathogenesis of autoimmunity and inflammatory bowel disease (IBD), respectively. Although selection of self-specific T cells in the thymus limits responses to mammalian tissue antigens, the mechanisms that control selection of commensal bacteria-specific T cells remain poorly understood. Here, we demonstrate that group 3 innate lymphoid cell (ILC3)-intrinsic expression of major histocompatibility complex class II (MHCII) is regulated similarly to thymic epithelial cells and that MHCII(+) ILC3s directly induce cell death of activated commensal bacteria-specific T cells. Further, MHCII on colonic ILC3s was reduced in pediatric IBD patients. Collectively, these results define a selection pathway for commensal bacteria-specific CD4(+) T cells in the intestine and suggest that this process is dysregulated in human IBD.
publishDate	2015
dc.date.none.fl_str_mv	2015 2015-01-01 2015 2015-01-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/122667
url	https://hdl.handle.net/10171/122667
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	American Association for the Advancement of Science
publisher.none.fl_str_mv	American Association for the Advancement of Science
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,812429

Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells

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