Native amides as Enabling Vehicles for Forging sp3–sp3 Architectures via Interrupted Deaminative Ni-catalyzed Chain-Walking

Herein, we disclose an interrupted deaminative Ni-catalyzed chain-walking strategy that forges sp3–sp3 architectures at remote, yet previously unfunctionalized, methylene sp3 C–H sites enabled by the presence of native amides. This protocol is characterized by its mild conditions and wide scope, inc...

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Detalles Bibliográficos
Autores: Rodrigalvarez, Jesus, Wang, Hao, Martin, Ruben
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2072/532807
Acceso en línea:http://hdl.handle.net/2072/532807
https://doi.org/10.1021/jacs.2c12915
Access Level:acceso abierto
Palabra clave:Química
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spelling Native amides as Enabling Vehicles for Forging sp3–sp3 Architectures via Interrupted Deaminative Ni-catalyzed Chain-WalkingRodrigalvarez, JesusWang, HaoMartin, RubenQuímica00Herein, we disclose an interrupted deaminative Ni-catalyzed chain-walking strategy that forges sp3–sp3 architectures at remote, yet previously unfunctionalized, methylene sp3 C–H sites enabled by the presence of native amides. This protocol is characterized by its mild conditions and wide scope, including challenging substrate combinations. Site-selectivity can be dictated by a judicious choice of the ligand, thus offering an opportunity to enable sp3–sp3 bond formations that are otherwise inaccessible in conventional chain-walking events.ACS Publications2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion7 p.application/pdfhttp://hdl.handle.net/2072/532807https://doi.org/10.1021/jacs.2c12915RECERCAT (Dipòsit de la Recerca de Catalunya)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésFEDER/MCI PID2021-123801NB-I00European Research Council (ERC) under European Union’s Horizon 2020 research and innovation program (grant agree ment 883756)Creative Commons. Attribution-NonCommercial-NoDerivativesinfo:eu-repo/semantics/openAccessoai:recercat.cat:2072/5328072026-05-29T05:05:01Z
dc.title.none.fl_str_mv Native amides as Enabling Vehicles for Forging sp3–sp3 Architectures via Interrupted Deaminative Ni-catalyzed Chain-Walking
title Native amides as Enabling Vehicles for Forging sp3–sp3 Architectures via Interrupted Deaminative Ni-catalyzed Chain-Walking
spellingShingle Native amides as Enabling Vehicles for Forging sp3–sp3 Architectures via Interrupted Deaminative Ni-catalyzed Chain-Walking
Rodrigalvarez, Jesus
Química
00
title_short Native amides as Enabling Vehicles for Forging sp3–sp3 Architectures via Interrupted Deaminative Ni-catalyzed Chain-Walking
title_full Native amides as Enabling Vehicles for Forging sp3–sp3 Architectures via Interrupted Deaminative Ni-catalyzed Chain-Walking
title_fullStr Native amides as Enabling Vehicles for Forging sp3–sp3 Architectures via Interrupted Deaminative Ni-catalyzed Chain-Walking
title_full_unstemmed Native amides as Enabling Vehicles for Forging sp3–sp3 Architectures via Interrupted Deaminative Ni-catalyzed Chain-Walking
title_sort Native amides as Enabling Vehicles for Forging sp3–sp3 Architectures via Interrupted Deaminative Ni-catalyzed Chain-Walking
dc.creator.none.fl_str_mv Rodrigalvarez, Jesus
Wang, Hao
Martin, Ruben
author Rodrigalvarez, Jesus
author_facet Rodrigalvarez, Jesus
Wang, Hao
Martin, Ruben
author_role author
author2 Wang, Hao
Martin, Ruben
author2_role author
author
dc.subject.none.fl_str_mv Química
00
topic Química
00
description Herein, we disclose an interrupted deaminative Ni-catalyzed chain-walking strategy that forges sp3–sp3 architectures at remote, yet previously unfunctionalized, methylene sp3 C–H sites enabled by the presence of native amides. This protocol is characterized by its mild conditions and wide scope, including challenging substrate combinations. Site-selectivity can be dictated by a judicious choice of the ligand, thus offering an opportunity to enable sp3–sp3 bond formations that are otherwise inaccessible in conventional chain-walking events.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/2072/532807
https://doi.org/10.1021/jacs.2c12915
url http://hdl.handle.net/2072/532807
https://doi.org/10.1021/jacs.2c12915
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv FEDER/MCI PID2021-123801NB-I00
European Research Council (ERC) under European Union’s Horizon 2020 research and innovation program (grant agree ment 883756)
dc.rights.none.fl_str_mv Creative Commons. Attribution-NonCommercial-NoDerivatives
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Creative Commons. Attribution-NonCommercial-NoDerivatives
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7 p.
application/pdf
dc.publisher.none.fl_str_mv ACS Publications
publisher.none.fl_str_mv ACS Publications
dc.source.none.fl_str_mv RECERCAT (Dipòsit de la Recerca de Catalunya)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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