Reconstructing the last common ancestor of all eukaryotes

Understanding the origin of eukaryotic cells is one of the most difficult problems in all of biology. A key challenge relevant to the question of eukaryogenesis is reconstructing the gene repertoire of the last eukaryotic common ancestor (LECA). As data sets grow, sketching an accurate genomics-info...

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Authors: Richards, Thomas A., Leger, Michelle M., Richter, Daniel J., Ruiz Trillo, Iñaki, Sebé-Pedrós, Arnau, Wideman, Jeremy G.
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/69519
Online Access:http://hdl.handle.net/10230/69519
http://dx.doi.org/10.1371/journal.pbio.3002917
Access Level:Open access
Keyword:Eukaryota
Eukaryotic evolution
Phylogenetics
Evolutionary genetics
Phylogenetic analysis
Hidden Markov models
Genomics
Microbial evolution
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spelling Reconstructing the last common ancestor of all eukaryotesRichards, Thomas A.Leger, Michelle M.Richter, Daniel J.Ruiz Trillo, IñakiSebé-Pedrós, ArnauWideman, Jeremy G.EukaryotaEukaryotic evolutionPhylogeneticsEvolutionary geneticsPhylogenetic analysisHidden Markov modelsGenomicsMicrobial evolutionUnderstanding the origin of eukaryotic cells is one of the most difficult problems in all of biology. A key challenge relevant to the question of eukaryogenesis is reconstructing the gene repertoire of the last eukaryotic common ancestor (LECA). As data sets grow, sketching an accurate genomics-informed picture of early eukaryotic cellular complexity requires provision of analytical resources and a commitment to data sharing. Here, we summarise progress towards understanding the biology of LECA and outline a community approach to inferring its wider gene repertoire. Once assembled, a robust LECA gene set will be a useful tool for evaluating alternative hypotheses about the origin of eukaryotes and understanding the evolution of traits in all descendant lineages, with relevance in diverse fields such as cell biology, microbial ecology, biotechnology, agriculture, and medicine. In this Consensus View, we put forth the status quo and an agreed path forward to reconstruct LECA's gene content.This work was supported by the Royal Society University Research Fellowship grant URF\R\191005 to TAR; Berlin Institute for Advanced Study (Wissenschaftskolleg zu Berlin) Fellowship to TAR; Gordon and Betty Moore Foundation Grant (GBMF9730) to TAR; HORIZON EUROPE European Research Council grant (803151) to LE; Simons Foundation Grant (735923LPI) to LE and AJR; Natural Sciences and Engineering Research Council of Canada Discovery Grant (RGPIN-2019-05058) to JMA; Gordon and Betty Moore Foundation Grant (GBMF5782) to JMA; Arthur B. McDonald Chair of Research Excellence at Dalhousie University to JMA; Natural Sciences and Engineering Research Council of Canada (RGPIN-2022-05430) to AJR; Natural Sciences and Engineering Research Council of Canada (RES0043758 & RES0046091) to JBD; National Science Foundation (2119963 & 2405455) to JGW, and Gordon and Betty Moore Foundation Grant (GBMF10600) to JGW. The funders had no role in the decision to publish, or the preparation of the manuscript.Public Library of Science (PLoS)202520252024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/69519http://dx.doi.org/10.1371/journal.pbio.3002917reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésPLoS Biol. 2024 Nov 25;22(11):e3002917info:eu-repo/grantAgreement/EC/H2020/803151© 2024 Richards et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/695192026-05-29T05:05:01Z
dc.title.none.fl_str_mv Reconstructing the last common ancestor of all eukaryotes
title Reconstructing the last common ancestor of all eukaryotes
spellingShingle Reconstructing the last common ancestor of all eukaryotes
Richards, Thomas A.
Eukaryota
Eukaryotic evolution
Phylogenetics
Evolutionary genetics
Phylogenetic analysis
Hidden Markov models
Genomics
Microbial evolution
title_short Reconstructing the last common ancestor of all eukaryotes
title_full Reconstructing the last common ancestor of all eukaryotes
title_fullStr Reconstructing the last common ancestor of all eukaryotes
title_full_unstemmed Reconstructing the last common ancestor of all eukaryotes
title_sort Reconstructing the last common ancestor of all eukaryotes
dc.creator.none.fl_str_mv Richards, Thomas A.
Leger, Michelle M.
Richter, Daniel J.
Ruiz Trillo, Iñaki
Sebé-Pedrós, Arnau
Wideman, Jeremy G.
author Richards, Thomas A.
author_facet Richards, Thomas A.
Leger, Michelle M.
Richter, Daniel J.
Ruiz Trillo, Iñaki
Sebé-Pedrós, Arnau
Wideman, Jeremy G.
author_role author
author2 Leger, Michelle M.
Richter, Daniel J.
Ruiz Trillo, Iñaki
Sebé-Pedrós, Arnau
Wideman, Jeremy G.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Eukaryota
Eukaryotic evolution
Phylogenetics
Evolutionary genetics
Phylogenetic analysis
Hidden Markov models
Genomics
Microbial evolution
topic Eukaryota
Eukaryotic evolution
Phylogenetics
Evolutionary genetics
Phylogenetic analysis
Hidden Markov models
Genomics
Microbial evolution
description Understanding the origin of eukaryotic cells is one of the most difficult problems in all of biology. A key challenge relevant to the question of eukaryogenesis is reconstructing the gene repertoire of the last eukaryotic common ancestor (LECA). As data sets grow, sketching an accurate genomics-informed picture of early eukaryotic cellular complexity requires provision of analytical resources and a commitment to data sharing. Here, we summarise progress towards understanding the biology of LECA and outline a community approach to inferring its wider gene repertoire. Once assembled, a robust LECA gene set will be a useful tool for evaluating alternative hypotheses about the origin of eukaryotes and understanding the evolution of traits in all descendant lineages, with relevance in diverse fields such as cell biology, microbial ecology, biotechnology, agriculture, and medicine. In this Consensus View, we put forth the status quo and an agreed path forward to reconstruct LECA's gene content.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/69519
http://dx.doi.org/10.1371/journal.pbio.3002917
url http://hdl.handle.net/10230/69519
http://dx.doi.org/10.1371/journal.pbio.3002917
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv PLoS Biol. 2024 Nov 25;22(11):e3002917
info:eu-repo/grantAgreement/EC/H2020/803151
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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