Centrosomes in Branching Morphogenesis

The centrosome, a major microtubule organizer, has important functions in regulating the cytoskeleton as well as the position of cellular structures and orientation of cells within tissues. The centrosome serves as the main cytoskeleton-organizing centre in the cell and is the classical site of micr...

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Detalles Bibliográficos
Autor: Araújo, Sofia J.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/198596
Acceso en línea:https://hdl.handle.net/2445/198596
Access Level:acceso abierto
Palabra clave:Axons
Cladística
Cèl·lules dendrítiques
Endoteli
Microtúbuls
Cladistic analysis
Dendritic cells
Endothelium
Microtubules
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spelling Centrosomes in Branching MorphogenesisAraújo, Sofia J.AxonsCladísticaCèl·lules dendrítiquesEndoteliMicrotúbulsAxonsCladistic analysisDendritic cellsEndotheliumMicrotubulesThe centrosome, a major microtubule organizer, has important functions in regulating the cytoskeleton as well as the position of cellular structures and orientation of cells within tissues. The centrosome serves as the main cytoskeleton-organizing centre in the cell and is the classical site of microtubule nucleation and anchoring. For these reasons, centrosomes play a very important role in morphogenesis, not just in the early stages of cell divisions but also in the later stages of organogenesis. Many organs such as lung, kidney and blood vessels develop from epithelial tubes that branch into complex networks. Cells in the nervous system also form highly branched structures in order to build complex neuronal networks. During branching morphogenesis, cells have to rearrange within tissues though multicellular branching or through subcellular branching, also known as single-cell branching. For highly branched structures to be formed during embryonic development, the cytoskeleton needs to be extensively remodelled. The centrosome has been shown to play an important role during these events.Springer Nature2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/198596Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1007/978-3-030-23173-6_13Results and Problems in Cell Differentiation, 2019, vol. 67, p. 323-336https://doi.org/10.1007/978-3-030-23173-6_13(c) Springer Nature, 2019info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1985962026-05-27T06:46:51Z
dc.title.none.fl_str_mv Centrosomes in Branching Morphogenesis
title Centrosomes in Branching Morphogenesis
spellingShingle Centrosomes in Branching Morphogenesis
Araújo, Sofia J.
Axons
Cladística
Cèl·lules dendrítiques
Endoteli
Microtúbuls
Axons
Cladistic analysis
Dendritic cells
Endothelium
Microtubules
title_short Centrosomes in Branching Morphogenesis
title_full Centrosomes in Branching Morphogenesis
title_fullStr Centrosomes in Branching Morphogenesis
title_full_unstemmed Centrosomes in Branching Morphogenesis
title_sort Centrosomes in Branching Morphogenesis
dc.creator.none.fl_str_mv Araújo, Sofia J.
author Araújo, Sofia J.
author_facet Araújo, Sofia J.
author_role author
dc.subject.none.fl_str_mv Axons
Cladística
Cèl·lules dendrítiques
Endoteli
Microtúbuls
Axons
Cladistic analysis
Dendritic cells
Endothelium
Microtubules
topic Axons
Cladística
Cèl·lules dendrítiques
Endoteli
Microtúbuls
Axons
Cladistic analysis
Dendritic cells
Endothelium
Microtubules
description The centrosome, a major microtubule organizer, has important functions in regulating the cytoskeleton as well as the position of cellular structures and orientation of cells within tissues. The centrosome serves as the main cytoskeleton-organizing centre in the cell and is the classical site of microtubule nucleation and anchoring. For these reasons, centrosomes play a very important role in morphogenesis, not just in the early stages of cell divisions but also in the later stages of organogenesis. Many organs such as lung, kidney and blood vessels develop from epithelial tubes that branch into complex networks. Cells in the nervous system also form highly branched structures in order to build complex neuronal networks. During branching morphogenesis, cells have to rearrange within tissues though multicellular branching or through subcellular branching, also known as single-cell branching. For highly branched structures to be formed during embryonic development, the cytoskeleton needs to be extensively remodelled. The centrosome has been shown to play an important role during these events.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/198596
url https://hdl.handle.net/2445/198596
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1007/978-3-030-23173-6_13
Results and Problems in Cell Differentiation, 2019, vol. 67, p. 323-336
https://doi.org/10.1007/978-3-030-23173-6_13
dc.rights.none.fl_str_mv (c) Springer Nature, 2019
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Springer Nature, 2019
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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