Theoretical potential for endometrial cancer prevention through primary risk factor modification: Estimates from the EPIC cohort

Endometrial cancer (EC) incidence rates vary ~10-fold worldwide, in part due to variation in EC risk factor profiles. Using an EC risk model previously developed in the European EPIC cohort, we evaluated the prevention potential of modified EC risk factor patterns and whether differences in EC incid...

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Detalles Bibliográficos
Autores: Fortner, Renée T., Hüsing, Anika, Dossus, Laure, Tjønneland, Anne, Overvad, Kim, Dahm, Christina C., Arveux, Patrick, Fournier, Agnès, Kvaskoff, Marina, Schulze, Matthias B., Bergmann, Manuela M., Trichopoulou, Antonia, Karakatsani, Anna, Vecchia, Carlo La, Masala, Giovanna, Pala, Valeria, Mattiello, Amalia, Tumino, Rosario, Ricceri, Fulvio, Gils, Carla H., Monninkhof, Evelyn M., Bonet Bonet, Catalina, Quirós, José Ramón, Sánchez Pérez, María José, Rodríguez Palacios, Daniel Ángel, Barricarte, Aurelio, Amiano, Pilar, Allen, Naomi E., Travis, Ruth C., Gunter, Marc J., Viallon, Vivian, Weiderpass, Elisabete, Riboli, Elio, Kaaks, Rudolf
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/174400
Acceso en línea:https://hdl.handle.net/2445/174400
Access Level:acceso abierto
Palabra clave:Càncer d'endometri
Pes corporal
Hormonoteràpia
Endometrial cancer
Body weight
Hormone therapy
Descripción
Sumario:Endometrial cancer (EC) incidence rates vary ~10-fold worldwide, in part due to variation in EC risk factor profiles. Using an EC risk model previously developed in the European EPIC cohort, we evaluated the prevention potential of modified EC risk factor patterns and whether differences in EC incidence between a European population and low-risk countries can be explained by differences in these patterns. Predicted EC incidence rates were estimated over 10 years of follow-up for the cohort before and after modifying risk factor profiles. Risk factors considered were: body mass index (BMI, kg/m2 ), use of postmenopausal hormone therapy (HT) and oral contraceptives (OC) (potentially modifiable); and, parity, ages at first birth, menarche and menopause (environmentally conditioned, but not readily modifiable). Modeled alterations in BMI (to all ≤23 kg/m2 ) and HT use (to all non-HT users) profiles resulted in a 30% reduction in predicted EC incidence rates; individually, longer duration of OC use (to all ≥10 years) resulted in a 42.5% reduction. Modeled changes in not readily modifiable exposures (i.e., those not contributing to prevention potential) resulted in ≤24.6% reduction in predicted EC incidence. Women in the lowest decile of a risk score based on the evaluated exposures had risk similar to a low risk countries; however, this was driven by relatively long use of OCs (median = 23 years). Our findings support avoidance of overweight BMI and of HT use as prevention strategies for EC in a European population; OC use must be considered in the context of benefits and risks.

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