The alternative life of RNA—sequencing meets single molecule approaches

The central dogma of RNA processing has started to totter. Single genes produce a variety of mRNA isoforms by mRNA modification, alternative polyadenylation (APA), and splicing. Different isoforms, even those that code for the identical protein, may differ in function or spatiotemporal expression. O...

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Detalhes bibliográficos
Autores: Fernández-Moya, Sandra M., Ehses, Janina, Kiebler, Michael A.
Formato: artículo
Fecha de publicación:2017
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/4614
Acesso em linha:http://hdl.handle.net/20.500.12328/4614
https://dx.doi.org/10.1002/1873-3468.12639
Access Level:acceso abierto
Palavra-chave:ARN
RNA
61
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spelling The alternative life of RNA—sequencing meets single molecule approachesFernández-Moya, Sandra M.Ehses, JaninaKiebler, Michael A.ARNRNA61The central dogma of RNA processing has started to totter. Single genes produce a variety of mRNA isoforms by mRNA modification, alternative polyadenylation (APA), and splicing. Different isoforms, even those that code for the identical protein, may differ in function or spatiotemporal expression. One option of how this can be achieved is by the selective recruitment of trans-acting factors to the 3′-untranslated region of a given isoform. Recent innovations in high-throughput RNA-sequencing methods allow deep insight into global RNA regulation, whereas novel imaging-based technologies enable researchers to explore single RNA molecules during different stages of development, in different tissues and different compartments of the cell. Resolving the dynamic function of ribonucleoprotein particles in splicing, APA, or RNA modification will enable us to understand their contribution to pathological conditions.info:eu-repo/semantics/publishedVersionWiley2017info:eu-repo/semantics/article15http://hdl.handle.net/20.500.12328/4614https://dx.doi.org/10.1002/1873-3468.12639reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésFEBS Letters591;11© John Wiley & Sons, Inc.info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/46142026-05-29T05:05:01Z
dc.title.none.fl_str_mv The alternative life of RNA—sequencing meets single molecule approaches
title The alternative life of RNA—sequencing meets single molecule approaches
spellingShingle The alternative life of RNA—sequencing meets single molecule approaches
Fernández-Moya, Sandra M.
ARN
RNA
61
title_short The alternative life of RNA—sequencing meets single molecule approaches
title_full The alternative life of RNA—sequencing meets single molecule approaches
title_fullStr The alternative life of RNA—sequencing meets single molecule approaches
title_full_unstemmed The alternative life of RNA—sequencing meets single molecule approaches
title_sort The alternative life of RNA—sequencing meets single molecule approaches
dc.creator.none.fl_str_mv Fernández-Moya, Sandra M.
Ehses, Janina
Kiebler, Michael A.
author Fernández-Moya, Sandra M.
author_facet Fernández-Moya, Sandra M.
Ehses, Janina
Kiebler, Michael A.
author_role author
author2 Ehses, Janina
Kiebler, Michael A.
author2_role author
author
dc.subject.none.fl_str_mv ARN
RNA
61
topic ARN
RNA
61
description The central dogma of RNA processing has started to totter. Single genes produce a variety of mRNA isoforms by mRNA modification, alternative polyadenylation (APA), and splicing. Different isoforms, even those that code for the identical protein, may differ in function or spatiotemporal expression. One option of how this can be achieved is by the selective recruitment of trans-acting factors to the 3′-untranslated region of a given isoform. Recent innovations in high-throughput RNA-sequencing methods allow deep insight into global RNA regulation, whereas novel imaging-based technologies enable researchers to explore single RNA molecules during different stages of development, in different tissues and different compartments of the cell. Resolving the dynamic function of ribonucleoprotein particles in splicing, APA, or RNA modification will enable us to understand their contribution to pathological conditions.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12328/4614
https://dx.doi.org/10.1002/1873-3468.12639
url http://hdl.handle.net/20.500.12328/4614
https://dx.doi.org/10.1002/1873-3468.12639
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv FEBS Letters
591;11
dc.rights.none.fl_str_mv © John Wiley & Sons, Inc.
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © John Wiley & Sons, Inc.
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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