Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium

16 páginas, 1 tabla, 3 figuras.

Detalhes bibliográficos
Autores: Oey, Harald, Zakrzewski, Martha, Gravermann, Kerstin, Young, Neil D., Korhonen, Pasi K., Gobert, Geoffrey N., Nawaratna, Sujeevi, Hasan, Shihab, Martínez, David M., You, Hong, Lavin, Martin, Jones, Malcolm K., Ragan, Mark A., Stoye, Jens, Oleaga, Ana, Emery, Aidan M., Webster, Bonnie L., Rollinson, David, Gasser, Robin B., McManus, Donald P., Krause, Lutz
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/177718
Acesso em linha:http://hdl.handle.net/10261/177718
Access Level:acceso abierto
Palavra-chave:Schistosoma haematobium
Schistosoma japonicum
S haematobium
Amino acid sequence
Disease control
Host parasite interaction
Mitochondrial genome
Schistosoma bovis
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repository_id_str
spelling Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobiumOey, HaraldZakrzewski, MarthaGravermann, KerstinYoung, Neil D.Korhonen, Pasi K.Gobert, Geoffrey N.Nawaratna, SujeeviHasan, ShihabMartínez, David M.You, HongLavin, MartinJones, Malcolm K.Ragan, Mark A.Stoye, JensOleaga, AnaEmery, Aidan M.Webster, Bonnie L.Rollinson, DavidGasser, Robin B.McManus, Donald P.Krause, LutzSchistosoma haematobiumSchistosoma japonicumS haematobiumAmino acid sequenceDisease controlHost parasite interactionMitochondrial genomeSchistosoma bovis16 páginas, 1 tabla, 3 figuras.Mesenteric infection by the parasitic blood fluke Schistosoma bovis is a common veterinary problem in Africa and the Middle East and occasionally in the Mediterranean Region. The species also has the ability to form interspecific hybrids with the human parasite S. haematobium with natural hybridisation observed in West Africa, presenting possible zoonotic transmission. Additionally, this exchange of alleles between species may dramatically influence disease dynamics and parasite evolution. We have generated a 374 Mb assembly of the S. bovis genome using Illumina and PacBio-based technologies. Despite infecting different hosts and organs, the genome sequences of S. bovis and S. haematobium appeared strikingly similar with 97% sequence identity. The two species share 98% of protein-coding genes, with an average sequence identity of 97.3% at the amino acid level. Genome comparison identified large continuous parts of the genome (up to several 100 kb) showing almost 100% sequence identity between S. bovis and S. haematobium. It is unlikely that this is a result of genome conservation and provides further evidence of natural interspecific hybridization between S. bovis and S. haematobium. Our results suggest that foreign DNA obtained by interspecific hybridization was maintained in the population through multiple meiosis cycles and that hybrids were sexually reproductive, producing viable offspring. The S. bovis genome assembly forms a highly valuable resource for studying schistosome evolution and exploring genetic regions that are associated with species-specific phenotypic traits.This work was supported by grants from the QIMR Berghofer Medical Research Institute (Chenhall Estate) and the Australian Infectious Diseases Research Centre. NDY was supported by a National Health and Medical Research Council (NHMRC) CDF1, PKK by an NHMRC ECRF and DPM by an NHMRC SPRF (APP1102926). The work has been supported by NHMRC project grant APP1102322.Peer reviewedPublic Library of ScienceOleaga, Ana [0000-0002-8019-7354]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/177718reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1371/journal.ppat.1007513Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1777182026-05-22T06:33:51Z
dc.title.none.fl_str_mv Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium
title Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium
spellingShingle Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium
Oey, Harald
Schistosoma haematobium
Schistosoma japonicum
S haematobium
Amino acid sequence
Disease control
Host parasite interaction
Mitochondrial genome
Schistosoma bovis
title_short Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium
title_full Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium
title_fullStr Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium
title_full_unstemmed Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium
title_sort Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium
dc.creator.none.fl_str_mv Oey, Harald
Zakrzewski, Martha
Gravermann, Kerstin
Young, Neil D.
Korhonen, Pasi K.
Gobert, Geoffrey N.
Nawaratna, Sujeevi
Hasan, Shihab
Martínez, David M.
You, Hong
Lavin, Martin
Jones, Malcolm K.
Ragan, Mark A.
Stoye, Jens
Oleaga, Ana
Emery, Aidan M.
Webster, Bonnie L.
Rollinson, David
Gasser, Robin B.
McManus, Donald P.
Krause, Lutz
author Oey, Harald
author_facet Oey, Harald
Zakrzewski, Martha
Gravermann, Kerstin
Young, Neil D.
Korhonen, Pasi K.
Gobert, Geoffrey N.
Nawaratna, Sujeevi
Hasan, Shihab
Martínez, David M.
You, Hong
Lavin, Martin
Jones, Malcolm K.
Ragan, Mark A.
Stoye, Jens
Oleaga, Ana
Emery, Aidan M.
Webster, Bonnie L.
Rollinson, David
Gasser, Robin B.
McManus, Donald P.
Krause, Lutz
author_role author
author2 Zakrzewski, Martha
Gravermann, Kerstin
Young, Neil D.
Korhonen, Pasi K.
Gobert, Geoffrey N.
Nawaratna, Sujeevi
Hasan, Shihab
Martínez, David M.
You, Hong
Lavin, Martin
Jones, Malcolm K.
Ragan, Mark A.
Stoye, Jens
Oleaga, Ana
Emery, Aidan M.
Webster, Bonnie L.
Rollinson, David
Gasser, Robin B.
McManus, Donald P.
Krause, Lutz
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Oleaga, Ana [0000-0002-8019-7354]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Schistosoma haematobium
Schistosoma japonicum
S haematobium
Amino acid sequence
Disease control
Host parasite interaction
Mitochondrial genome
Schistosoma bovis
topic Schistosoma haematobium
Schistosoma japonicum
S haematobium
Amino acid sequence
Disease control
Host parasite interaction
Mitochondrial genome
Schistosoma bovis
description 16 páginas, 1 tabla, 3 figuras.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/177718
url http://hdl.handle.net/10261/177718
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1371/journal.ppat.1007513
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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