Endovascular repair of aortic dissection with a bioresorbable patch: Computational and experimental study

This study introduces an experimentally-calibrated finite-element framework to predict the endovascular sealing performance of a bioresorbable patch for aortic dissection repair. The patch–aortic wall interaction was modeled using an adhesion-enabled contact formulation, with parameters derived from...

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Detalles Bibliográficos
Autores: Bracco, Marta Irene, Canalejo-Codina, Francesc, Giuliodori, Agustina, Montanino, Andrea, Martorell, Jordi, Soudah, Eduardo
Tipo de recurso: artículo
Fecha de publicación:2026
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.14342/5880
Acceso en línea:http://hdl.handle.net/20.500.14342/5880
https://doi.org/10.1016/j.apples.2025.100277
Access Level:acceso abierto
Palabra clave:Aortic dissection
Endovascular technique
Aortic tear sealing
Finite element method
Contact model
Dissecció aòrtica
Elements finits, Mètode dels
616.1
62
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spelling Endovascular repair of aortic dissection with a bioresorbable patch: Computational and experimental studyBracco, Marta IreneCanalejo-Codina, FrancescGiuliodori, AgustinaMontanino, AndreaMartorell, JordiSoudah, EduardoAortic dissectionEndovascular techniqueAortic tear sealingFinite element methodContact modelDissecció aòrticaElements finits, Mètode dels616.162This study introduces an experimentally-calibrated finite-element framework to predict the endovascular sealing performance of a bioresorbable patch for aortic dissection repair. The patch–aortic wall interaction was modeled using an adhesion-enabled contact formulation, with parameters derived from a custom dye-penetration test to replicate in-vivo tissue adhesion. A parametric analysis assessed the impact of tear size (10–20 mm), tear morphology (round vs. circumferential ellipse), and deployment angle (5º–20º) on patch sealing efficiency, wall compliance, and local stress distribution under physiological loading. Tear geometry was identified as the dominant determinant of sealing: large round tears reduced effective apposition, while circumferential elliptical tears promoted full wall coupling at lower deployment forces. Increasing deployment angle raised insertion forces and impaired circumferential contact. Importantly, pulsatile hemodynamic loading demonstrated that the patch preserved native wall compliance without inducing adverse stress concentrations. By integrating experimental calibration with computational modeling, this framework offers a quantitative tool to evaluate anatomical and procedural factors influencing endovascular sealing. These insights may support the design optimization and clinical translation of resorbable patch-based strategies for aortic dissection repair.info:eu-repo/semantics/publishedVersionElsevierUniversitat Ramon Llull. IQS2026info:eu-repo/semantics/articlep.9http://hdl.handle.net/20.500.14342/5880https://doi.org/10.1016/j.apples.2025.100277reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésApplications in Engineering Science 2025, 25, 100277info:eu-repo/grantAgreement/MCI/PN I+D/CPP2021-008546info:eu-repo/grantAgreement/MCI/PN I+D/PID2021-122518OB-I00info:eu-repo/grantAgreement/Fundació la Marató de TV3/202332-30/info:eu-repo/grantAgreement/EC/HE/190192260© L'autor/aAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.14342/58802026-05-29T05:05:01Z
dc.title.none.fl_str_mv Endovascular repair of aortic dissection with a bioresorbable patch: Computational and experimental study
title Endovascular repair of aortic dissection with a bioresorbable patch: Computational and experimental study
spellingShingle Endovascular repair of aortic dissection with a bioresorbable patch: Computational and experimental study
Bracco, Marta Irene
Aortic dissection
Endovascular technique
Aortic tear sealing
Finite element method
Contact model
Dissecció aòrtica
Elements finits, Mètode dels
616.1
62
title_short Endovascular repair of aortic dissection with a bioresorbable patch: Computational and experimental study
title_full Endovascular repair of aortic dissection with a bioresorbable patch: Computational and experimental study
title_fullStr Endovascular repair of aortic dissection with a bioresorbable patch: Computational and experimental study
title_full_unstemmed Endovascular repair of aortic dissection with a bioresorbable patch: Computational and experimental study
title_sort Endovascular repair of aortic dissection with a bioresorbable patch: Computational and experimental study
dc.creator.none.fl_str_mv Bracco, Marta Irene
Canalejo-Codina, Francesc
Giuliodori, Agustina
Montanino, Andrea
Martorell, Jordi
Soudah, Eduardo
author Bracco, Marta Irene
author_facet Bracco, Marta Irene
Canalejo-Codina, Francesc
Giuliodori, Agustina
Montanino, Andrea
Martorell, Jordi
Soudah, Eduardo
author_role author
author2 Canalejo-Codina, Francesc
Giuliodori, Agustina
Montanino, Andrea
Martorell, Jordi
Soudah, Eduardo
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Ramon Llull. IQS
dc.subject.none.fl_str_mv Aortic dissection
Endovascular technique
Aortic tear sealing
Finite element method
Contact model
Dissecció aòrtica
Elements finits, Mètode dels
616.1
62
topic Aortic dissection
Endovascular technique
Aortic tear sealing
Finite element method
Contact model
Dissecció aòrtica
Elements finits, Mètode dels
616.1
62
description This study introduces an experimentally-calibrated finite-element framework to predict the endovascular sealing performance of a bioresorbable patch for aortic dissection repair. The patch–aortic wall interaction was modeled using an adhesion-enabled contact formulation, with parameters derived from a custom dye-penetration test to replicate in-vivo tissue adhesion. A parametric analysis assessed the impact of tear size (10–20 mm), tear morphology (round vs. circumferential ellipse), and deployment angle (5º–20º) on patch sealing efficiency, wall compliance, and local stress distribution under physiological loading. Tear geometry was identified as the dominant determinant of sealing: large round tears reduced effective apposition, while circumferential elliptical tears promoted full wall coupling at lower deployment forces. Increasing deployment angle raised insertion forces and impaired circumferential contact. Importantly, pulsatile hemodynamic loading demonstrated that the patch preserved native wall compliance without inducing adverse stress concentrations. By integrating experimental calibration with computational modeling, this framework offers a quantitative tool to evaluate anatomical and procedural factors influencing endovascular sealing. These insights may support the design optimization and clinical translation of resorbable patch-based strategies for aortic dissection repair.
publishDate 2026
dc.date.none.fl_str_mv 2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.14342/5880
https://doi.org/10.1016/j.apples.2025.100277
url http://hdl.handle.net/20.500.14342/5880
https://doi.org/10.1016/j.apples.2025.100277
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Applications in Engineering Science 2025, 25, 100277
info:eu-repo/grantAgreement/MCI/PN I+D/CPP2021-008546
info:eu-repo/grantAgreement/MCI/PN I+D/PID2021-122518OB-I00
info:eu-repo/grantAgreement/Fundació la Marató de TV3/202332-30/
info:eu-repo/grantAgreement/EC/HE/190192260
dc.rights.none.fl_str_mv © L'autor/a
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © L'autor/a
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv p.9
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869425222581485568
score 15,811543

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