Long Neurocognitive and Neuropsychiatric Sequelae in Participants with Post-COVID-19 Infection

Objective: To evaluate and characterize the cognitive changes in COVID-19 participants at 6-month follow-up, and to explore a possible association with clinical symptoms, emotional disturbance and disease severity. Methods: This single-center longitudinal cohort study included participants aged 20 a...

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Autores: Almeria, Marta|||0000-0001-7445-6113, Cejudo, Juan Carlos|||0000-0001-6355-8499, Deus Yela, Juan|||0000-0002-3305-2662, Krupinski, Jerzy|||0000-0002-5136-8898
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:300951
Acceso en línea:https://ddd.uab.cat/record/300951
https://dx.doi.org/urn:doi:10.3390/neurolint16040064
Access Level:acceso abierto
Palabra clave:Long COVID-19
Cognition
Subjective cognitive complaints
Persistent symptoms
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spelling Long Neurocognitive and Neuropsychiatric Sequelae in Participants with Post-COVID-19 InfectionA Longitudinal StudyAlmeria, Marta|||0000-0001-7445-6113Cejudo, Juan Carlos|||0000-0001-6355-8499Deus Yela, Juan|||0000-0002-3305-2662Krupinski, Jerzy|||0000-0002-5136-8898Long COVID-19CognitionSubjective cognitive complaintsPersistent symptomsObjective: To evaluate and characterize the cognitive changes in COVID-19 participants at 6-month follow-up, and to explore a possible association with clinical symptoms, emotional disturbance and disease severity. Methods: This single-center longitudinal cohort study included participants aged 20 and 60 years old to exclude cognitive impairment age-associated with confirmed COVID-19 infection. The initial evaluation occurred 10 to 30 days after hospital or ambulatory discharge, with a subsequent follow-up at 6 months. Patients who had a history of cognitive impairment, neurological conditions, or serious psychiatric disorders were not included. Information on demographics and laboratory results was gathered from medical records. Cognitive outcomes were assessed with a neuropsychological battery including attention, verbal and visual memory, language and executive function tests. Results: A total of 200 participants were included in the study, and 108 completed the follow-up visit. At the 6-month follow-up, comparing the means from baseline with those of the follow-up evaluation, significant overall improvement was observed in verbal and visual memory subtests (p = 0.001), processing speed (p = 0.001), executive function (p = 0.028; p = 0.016) and naming (p = 0.001), independently of disease severity and cognitive complaints. Anxiety and depression were significantly higher in groups with Subjective Cognitive Complaints (SCC) compared to those without (p < 0.01 for both). Conclusions: Persistent symptoms are common regardless of disease severity and are often linked to cognitive complaints. Six months after COVID-19, the most frequently reported symptoms included headache, dyspnea, fatigue, cognitive complaints, anxiety, and depression. No cognitive impairment was found to be associated with the severity of COVID-19. Overall, neuropsychological and psychopathological improvement was observed at 6 months regardless of disease severity and cognitive complaints. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/300951https://dx.doi.org/urn:doi:10.3390/neurolint16040064reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/02089open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3009512026-06-06T12:50:31Z
dc.title.none.fl_str_mv Long Neurocognitive and Neuropsychiatric Sequelae in Participants with Post-COVID-19 Infection
A Longitudinal Study
title Long Neurocognitive and Neuropsychiatric Sequelae in Participants with Post-COVID-19 Infection
spellingShingle Long Neurocognitive and Neuropsychiatric Sequelae in Participants with Post-COVID-19 Infection
Almeria, Marta|||0000-0001-7445-6113
Long COVID-19
Cognition
Subjective cognitive complaints
Persistent symptoms
title_short Long Neurocognitive and Neuropsychiatric Sequelae in Participants with Post-COVID-19 Infection
title_full Long Neurocognitive and Neuropsychiatric Sequelae in Participants with Post-COVID-19 Infection
title_fullStr Long Neurocognitive and Neuropsychiatric Sequelae in Participants with Post-COVID-19 Infection
title_full_unstemmed Long Neurocognitive and Neuropsychiatric Sequelae in Participants with Post-COVID-19 Infection
title_sort Long Neurocognitive and Neuropsychiatric Sequelae in Participants with Post-COVID-19 Infection
dc.creator.none.fl_str_mv Almeria, Marta|||0000-0001-7445-6113
Cejudo, Juan Carlos|||0000-0001-6355-8499
Deus Yela, Juan|||0000-0002-3305-2662
Krupinski, Jerzy|||0000-0002-5136-8898
author Almeria, Marta|||0000-0001-7445-6113
author_facet Almeria, Marta|||0000-0001-7445-6113
Cejudo, Juan Carlos|||0000-0001-6355-8499
Deus Yela, Juan|||0000-0002-3305-2662
Krupinski, Jerzy|||0000-0002-5136-8898
author_role author
author2 Cejudo, Juan Carlos|||0000-0001-6355-8499
Deus Yela, Juan|||0000-0002-3305-2662
Krupinski, Jerzy|||0000-0002-5136-8898
author2_role author
author
author
dc.subject.none.fl_str_mv Long COVID-19
Cognition
Subjective cognitive complaints
Persistent symptoms
topic Long COVID-19
Cognition
Subjective cognitive complaints
Persistent symptoms
description Objective: To evaluate and characterize the cognitive changes in COVID-19 participants at 6-month follow-up, and to explore a possible association with clinical symptoms, emotional disturbance and disease severity. Methods: This single-center longitudinal cohort study included participants aged 20 and 60 years old to exclude cognitive impairment age-associated with confirmed COVID-19 infection. The initial evaluation occurred 10 to 30 days after hospital or ambulatory discharge, with a subsequent follow-up at 6 months. Patients who had a history of cognitive impairment, neurological conditions, or serious psychiatric disorders were not included. Information on demographics and laboratory results was gathered from medical records. Cognitive outcomes were assessed with a neuropsychological battery including attention, verbal and visual memory, language and executive function tests. Results: A total of 200 participants were included in the study, and 108 completed the follow-up visit. At the 6-month follow-up, comparing the means from baseline with those of the follow-up evaluation, significant overall improvement was observed in verbal and visual memory subtests (p = 0.001), processing speed (p = 0.001), executive function (p = 0.028; p = 0.016) and naming (p = 0.001), independently of disease severity and cognitive complaints. Anxiety and depression were significantly higher in groups with Subjective Cognitive Complaints (SCC) compared to those without (p < 0.01 for both). Conclusions: Persistent symptoms are common regardless of disease severity and are often linked to cognitive complaints. Six months after COVID-19, the most frequently reported symptoms included headache, dyspnea, fatigue, cognitive complaints, anxiety, and depression. No cognitive impairment was found to be associated with the severity of COVID-19. Overall, neuropsychological and psychopathological improvement was observed at 6 months regardless of disease severity and cognitive complaints.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/300951
https://dx.doi.org/urn:doi:10.3390/neurolint16040064
url https://ddd.uab.cat/record/300951
https://dx.doi.org/urn:doi:10.3390/neurolint16040064
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/02089
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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