Modulation of the endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans
Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive impairments. However, to date, no published reports est...
| Autores: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2013 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositório: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/65652 |
| Acesso em linha: | https://hdl.handle.net/2445/65652 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Cànnabis Cognició Presa de decisions Endocrinologia Cannabis Cognition Decision making Endocrinology |
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Modulation of the endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humansFagundo, Ana BeatrizTorre Fornell, Rafael de laJiménez-Murcia, SusanaAgüera, ZaidaPastor, AntoniCasanueva, Felipe F.Granero, RoserBaños Rivera, Rosa MaríaBotella Arbona, CristinaDel Pino Gutiérrez, AmparoFernández-Real Lemos, José ManuelFernández García, José C.Frühbeck, GemaGómez Ambrosi, JavierMenchón Magriñá, José ManuelMoragrega, InésRodríguez, RoserTárrega, SaloméTinahones, Francisco J.Fernández Aranda, FernandoCànnabisCognicióPresa de decisionsEndocrinologiaCannabisCognitionDecision makingEndocrinologyAnimal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive impairments. However, to date, no published reports establish the relationship between endocannabinoids, as biomarkers of the cannabinoid neurotransmission system, and executive functioning in humans. The aim of the present study was to explore the association between circulating levels of plasma endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) and executive functions (decision making, response inhibition and cognitive flexibility) in healthy subjects. One hundred and fifty seven subjects were included and assessed with the Wisconsin Card Sorting Test; Stroop Color and Word Test; and Iowa Gambling Task. All participants were female, aged between 18 and 60 years and spoke Spanish as their first language. Results showed a negative correlation between 2-AG and cognitive flexibility performance (r = −.37; p<.05). A positive correlation was found between AEA concentrations and both cognitive flexibility (r = .59; p<.05) and decision making performance (r = .23; P<.05). There was no significant correlation between either 2-AG (r = −.17) or AEA (r = −.08) concentrations and inhibition response. These results show, in humans, a relevant modulation of the endocannabinoid system on prefrontal-dependent cognitive functioning. The present study might have significant implications for the underlying executive alterations described in some psychiatric disorders currently associated with endocannabinoids deregulation (namely drug abuse/dependence, depression, obesity and eating disorders). Understanding the neurobiology of their dysexecutive profile might certainly contribute to the development of new treatments and pharmacological approaches.Public Library of Science (PLoS)2015201520132015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 p.application/pdfhttps://hdl.handle.net/2445/65652Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0066387PLoS One, 2013, vol. 8, num. 6, p. 1-7http://dx.doi.org/10.1371/journal.pone.0066387cc-by (c) Fagundo, Anna B. et al., 2013http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/656522026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Modulation of the endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans |
| title |
Modulation of the endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans |
| spellingShingle |
Modulation of the endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans Fagundo, Ana Beatriz Cànnabis Cognició Presa de decisions Endocrinologia Cannabis Cognition Decision making Endocrinology |
| title_short |
Modulation of the endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans |
| title_full |
Modulation of the endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans |
| title_fullStr |
Modulation of the endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans |
| title_full_unstemmed |
Modulation of the endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans |
| title_sort |
Modulation of the endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans |
| dc.creator.none.fl_str_mv |
Fagundo, Ana Beatriz Torre Fornell, Rafael de la Jiménez-Murcia, Susana Agüera, Zaida Pastor, Antoni Casanueva, Felipe F. Granero, Roser Baños Rivera, Rosa María Botella Arbona, Cristina Del Pino Gutiérrez, Amparo Fernández-Real Lemos, José Manuel Fernández García, José C. Frühbeck, Gema Gómez Ambrosi, Javier Menchón Magriñá, José Manuel Moragrega, Inés Rodríguez, Roser Tárrega, Salomé Tinahones, Francisco J. Fernández Aranda, Fernando |
| author |
Fagundo, Ana Beatriz |
| author_facet |
Fagundo, Ana Beatriz Torre Fornell, Rafael de la Jiménez-Murcia, Susana Agüera, Zaida Pastor, Antoni Casanueva, Felipe F. Granero, Roser Baños Rivera, Rosa María Botella Arbona, Cristina Del Pino Gutiérrez, Amparo Fernández-Real Lemos, José Manuel Fernández García, José C. Frühbeck, Gema Gómez Ambrosi, Javier Menchón Magriñá, José Manuel Moragrega, Inés Rodríguez, Roser Tárrega, Salomé Tinahones, Francisco J. Fernández Aranda, Fernando |
| author_role |
author |
| author2 |
Torre Fornell, Rafael de la Jiménez-Murcia, Susana Agüera, Zaida Pastor, Antoni Casanueva, Felipe F. Granero, Roser Baños Rivera, Rosa María Botella Arbona, Cristina Del Pino Gutiérrez, Amparo Fernández-Real Lemos, José Manuel Fernández García, José C. Frühbeck, Gema Gómez Ambrosi, Javier Menchón Magriñá, José Manuel Moragrega, Inés Rodríguez, Roser Tárrega, Salomé Tinahones, Francisco J. Fernández Aranda, Fernando |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Cànnabis Cognició Presa de decisions Endocrinologia Cannabis Cognition Decision making Endocrinology |
| topic |
Cànnabis Cognició Presa de decisions Endocrinologia Cannabis Cognition Decision making Endocrinology |
| description |
Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive impairments. However, to date, no published reports establish the relationship between endocannabinoids, as biomarkers of the cannabinoid neurotransmission system, and executive functioning in humans. The aim of the present study was to explore the association between circulating levels of plasma endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) and executive functions (decision making, response inhibition and cognitive flexibility) in healthy subjects. One hundred and fifty seven subjects were included and assessed with the Wisconsin Card Sorting Test; Stroop Color and Word Test; and Iowa Gambling Task. All participants were female, aged between 18 and 60 years and spoke Spanish as their first language. Results showed a negative correlation between 2-AG and cognitive flexibility performance (r = −.37; p<.05). A positive correlation was found between AEA concentrations and both cognitive flexibility (r = .59; p<.05) and decision making performance (r = .23; P<.05). There was no significant correlation between either 2-AG (r = −.17) or AEA (r = −.08) concentrations and inhibition response. These results show, in humans, a relevant modulation of the endocannabinoid system on prefrontal-dependent cognitive functioning. The present study might have significant implications for the underlying executive alterations described in some psychiatric disorders currently associated with endocannabinoids deregulation (namely drug abuse/dependence, depression, obesity and eating disorders). Understanding the neurobiology of their dysexecutive profile might certainly contribute to the development of new treatments and pharmacological approaches. |
| publishDate |
2013 |
| dc.date.none.fl_str_mv |
2013 2015 2015 2015 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/65652 |
| url |
https://hdl.handle.net/2445/65652 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0066387 PLoS One, 2013, vol. 8, num. 6, p. 1-7 http://dx.doi.org/10.1371/journal.pone.0066387 |
| dc.rights.none.fl_str_mv |
cc-by (c) Fagundo, Anna B. et al., 2013 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc-by (c) Fagundo, Anna B. et al., 2013 http://creativecommons.org/licenses/by/3.0/es |
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openAccess |
| dc.format.none.fl_str_mv |
7 p. application/pdf |
| dc.publisher.none.fl_str_mv |
Public Library of Science (PLoS) |
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Public Library of Science (PLoS) |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Ciències Clíniques) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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