Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer

Recent findings indicate that the expression of the beta-catalytic subunit of the mitochondrial H+-ATP synthase (beta-F1-ATPase) is depressed in liver, kidney and colon carcinomas, providing further a bioenergetic signature of cancer that is associated with patient survival. In the present study, we...

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Autores: Isidoro, Antonio, Martínez-Díez, Marta, Fernández, Pedro L., Ortega, Álvaro D., Santamaría, Gema, Chamorro, Margarita, Reed, John C., Cuezva, José M.
Tipo de recurso: artículo
Fecha de publicación:2003
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/8239
Acceso en línea:http://hdl.handle.net/10261/8239
Access Level:acceso abierto
Palabra clave:Cancer
Glycolysis
H+-ATP synthase
Mitochondria
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spelling Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancerIsidoro, AntonioMartínez-Díez, MartaFernández, Pedro L.Ortega, Álvaro D.Santamaría, GemaChamorro, MargaritaReed, John C.Cuezva, José M.CancerGlycolysisH+-ATP synthaseMitochondriaRecent findings indicate that the expression of the beta-catalytic subunit of the mitochondrial H+-ATP synthase (beta-F1-ATPase) is depressed in liver, kidney and colon carcinomas, providing further a bioenergetic signature of cancer that is associated with patient survival. In the present study, we performed an analysis of mitochondrial and glycolytic protein markers in breast, gastric and prostate adenocarcinomas, and in squamous oesophageal and lung carcinomas. The expression of mitochondrial and glycolytic markers varied significantly in these carcinomas, when compared with paired normal tissues, with the exception of prostate cancer. Overall, the relative expression of beta-F1-ATPase was significantly reduced in breast and gastric adenocarcinomas, as well as in squamous oesophageal and lung carcinomas, strongly suggesting that alteration of the bioenergetic function of mitochondria is a hallmark of these types of cancer.A.I. is the recipient of a pre-doctoral fellowship from Fondo de Investigaciones Sanitarias (Ministerio de Sanidad y Consumo, Spain). M.M., G.S. and A.D.O are the recipients of pre-doctoral fellowships from Plan de Formación de Personal Investigador (Ministerio de Ciencia y Tecnología, Spain) and Programa Nacional de Formación de Profesorado (Ministerio de Educación, Cultura y Deporte, Spain) respectively. This work was supported by grants 01/0380 from Ministerio de Sanidad y Consumo and BMC2001-0710 from Ministerio de Ciencia y Tecnología to J.M.C. (Spain), 01/1519 from Ministerio de Sanidad y Consumo and AECC (Asociación Española Contra el Cancer) to P.L.F. (Spain) and from the National Institutes of Health (GM60554) to J.C.R. (U.S.A.). The CBMSO receives an institutional grant from Fundación Ramón Areces, SpainPeer reviewedBiochemical SocietyInstituto de Salud Carlos IIIMinisterio de Ciencia y Tecnología (España)Ministerio de Educación, Cultura y Deporte (España)Asociación Española Contra el CáncerNational Institutes of Health (US)Fundación Ramón Areces200820082003info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501147615 bytesapplication/pdfhttp://hdl.handle.net/10261/8239reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1042/BJ20031541info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/82392026-05-22T06:33:51Z
dc.title.none.fl_str_mv Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer
title Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer
spellingShingle Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer
Isidoro, Antonio
Cancer
Glycolysis
H+-ATP synthase
Mitochondria
title_short Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer
title_full Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer
title_fullStr Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer
title_full_unstemmed Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer
title_sort Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer
dc.creator.none.fl_str_mv Isidoro, Antonio
Martínez-Díez, Marta
Fernández, Pedro L.
Ortega, Álvaro D.
Santamaría, Gema
Chamorro, Margarita
Reed, John C.
Cuezva, José M.
author Isidoro, Antonio
author_facet Isidoro, Antonio
Martínez-Díez, Marta
Fernández, Pedro L.
Ortega, Álvaro D.
Santamaría, Gema
Chamorro, Margarita
Reed, John C.
Cuezva, José M.
author_role author
author2 Martínez-Díez, Marta
Fernández, Pedro L.
Ortega, Álvaro D.
Santamaría, Gema
Chamorro, Margarita
Reed, John C.
Cuezva, José M.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Ministerio de Ciencia y Tecnología (España)
Ministerio de Educación, Cultura y Deporte (España)
Asociación Española Contra el Cáncer
National Institutes of Health (US)
Fundación Ramón Areces
dc.subject.none.fl_str_mv Cancer
Glycolysis
H+-ATP synthase
Mitochondria
topic Cancer
Glycolysis
H+-ATP synthase
Mitochondria
description Recent findings indicate that the expression of the beta-catalytic subunit of the mitochondrial H+-ATP synthase (beta-F1-ATPase) is depressed in liver, kidney and colon carcinomas, providing further a bioenergetic signature of cancer that is associated with patient survival. In the present study, we performed an analysis of mitochondrial and glycolytic protein markers in breast, gastric and prostate adenocarcinomas, and in squamous oesophageal and lung carcinomas. The expression of mitochondrial and glycolytic markers varied significantly in these carcinomas, when compared with paired normal tissues, with the exception of prostate cancer. Overall, the relative expression of beta-F1-ATPase was significantly reduced in breast and gastric adenocarcinomas, as well as in squamous oesophageal and lung carcinomas, strongly suggesting that alteration of the bioenergetic function of mitochondria is a hallmark of these types of cancer.
publishDate 2003
dc.date.none.fl_str_mv 2003
2008
2008
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/8239
url http://hdl.handle.net/10261/8239
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1042/BJ20031541
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 147615 bytes
application/pdf
dc.publisher.none.fl_str_mv Biochemical Society
publisher.none.fl_str_mv Biochemical Society
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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